Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Hematology > Hemopoesis > Flashcards

Hemopoesis Flashcards

1
Q

What are the cells in a normal blood

A

WBC
RBC
Platelets

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What is situated within the cavity of a bone

A

Red spongy tissue

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Hematopoietic stem cells gives rise to all the cells in the blood. T/F

A

True

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Cells in the blood are made inside the blood vessels. T/F

A

False! They are made in the bone marrow

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What are the two types of hematopoietic stem cells?

A

Myeloid and lymphoid cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What are the two lymphoid cells?

A

T cells and B cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What lymphoid cell is referred to as a naked nucleus and why?

A

T cell! Because the nucleus is so large it looks like the nucleus isn’t surrounded by cytoplasm

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What gives RBC its colour?

A

Haemoglobin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

T/F
RBC have nuclei
The periphery of RBC is less thicker than the centre

A

False
False

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

What cells give rise to platelets?

A

Megakaryocytes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What is an example of a WBC that has its nucleus in one piece?

A

Monocytes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

How do monocytes fight bacteria and virus?

A

They engulf them in a what that’s looks like they are eating them up

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

What WBC has the bean shaped appearance

A

Monocytes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

An example of a multisegmented nuclei is?

A

Neutrophil

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

What are the main components of pimples?

A

Neutrophil

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

What cell has bright blue granules in its cytoplasm?

A

Basophils

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

What cell has bright red granules in it’s cytoplasm and has a nucleus in two piece

A

Eosinophils

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

Eosinophil, basophil and neutrophil all develop from?

A

Myeloblast

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

During gestation(3rd month) stem cells migrate from where to where?

A

Yolk sac to liver, spleen and lymph nodes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

By the 4th week of gestation some stem cells move from where to where?

A

Liver, spleen and lymph nodes to the Bone marrow

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

Blood formation occurs mainly where?

A

Bone marrow

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

Where does blood form in developing fetus in first 1-3 months?

A

Yolk sac

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

Blood formation moves to the liver in the 4th month of IUL. T/F

A

True

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

By the end of the 4th month blood formation in the liver begins to increase. T/F

A

False. Decrease

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
Q

The liver and spleen no longer forms blood by what month?

A

6th-7th month

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
26
Q

Between what months after birth do all bones in the body form blood

A

7th month of IUL—24months after birth

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
27
Q

After age 3 years blood formation begins to decrease for some bones in the body. T/F

A

False. 2 years

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
28
Q

Despite the decrease/stoppage of blood in bones of the body after maturation some bones still form blood what are they?

A

Bone of the base of the skull
Vertebral column
Rib cage
Shoulder girdle
Pelvic girdle

29
Q

After the age of — years blood formation in long bones disappears or decreases

A

18years

30
Q

What’s the name of the factor within the bone marrow that forms blood called?

A

Haematopoetic inductive micro environment

31
Q

Describe the blood supply to bone

A

Nutrient artery

32
Q

The outer and inner surface of HIM is called?

A

Luminal and Abluminal surface

33
Q

Blood flows past HIM hence whatever surface blood is touching is lined by?

A

Endothelial cells

34
Q

The abluminal surface is lined by?

A

Adipocytes
Fibroblasts
Reticular/adventitia cells
Marrow stromal cells
Macrophages

35
Q

Adventitia cells are responsible for?

A

Secretion of reticulin fibers into the matrix tissue into the HIM space

36
Q

Fibroblasts and stroma secrete what?

A

Collagen I,III, IV into the HIM space

37
Q

All abluminal cells synthesize and secrete into HIM space what component?

A

Aminoglycans

38
Q

Examples of Aminoglycan

A

Hyaluronic acid
Heparan sulphate
Chondroitin(IV)sulphate
Dermatan

39
Q

Abluminal cells also secrete what?

A

Haematopoetic Growth factors
GCSF
GMCSF

40
Q

What are other proteins that help promote Haemopoesis

A

Fibronectin
Hemonectin
Vitronectin
Laminin
Tenascin
Endoglin

41
Q

What do proteins like fibronectin do?

A

Ensure that immature hematopoietic cells are retained and not allowed to leave the HIM until maturation

42
Q

Where does hemopoesis occur

A

Within the HIM space

43
Q

Hemopoetic cells include?

A

Thrombocytes
Leukocytes
Erythrocytes/erythrocytes cells

44
Q

Leukocytes have different subtypes what are they?

A

Granulocytes(basophil, eosinophils, neutrophils)
Lymphocytes
Monocytes

45
Q

What is island if cells?

A

Cluster of cells

46
Q

The islands of epo cells are found where?

A

In juxtaposition to the Abluminal surface cells

46
Q

The islands of erythropoetic cells are found where?

A

In juxtaposition to the Abluminal surface cells

47
Q

What other island of cells with the exception of Erythropoesis is found in juxtaposition to the abluminal cells?

A

Megakaryocytopoesis(thrombopoesis)

48
Q

Where does Granulocytopoesis occur?

A

In between erythropoesis and megakaryocytopoesis

49
Q

At the very center of HIM is?

A

Lymphocytopoesis

50
Q

All cells are derived from the most primitive cells in the bone marrow called?

A

Pluripotentential stem cells

51
Q

What are the important properties of stem cell?

A

Mitotic division and renewal
Mitotic division and differentiation

52
Q

PPSC can also divide and form another PPSC. T/F?

A

True

53
Q

PPSC differentiates into?

A

Myeloid cells and Lymphoid committed stem cells

54
Q

Myeloid committed stem cells is also capable of self renewal called?

A

Perpetuation

55
Q

Myeloid CSC differentiates into?

A

BFU-E, BFU-MK, HPP-CFC

56
Q

BFU-E, BFU-MK, HPP-CPC have stem cells. T/F?

A

False

57
Q

Cells committed to a hematopoietic lineage but have no microscopic or morphological lineage are?

A

Progenitor cells

58
Q

What are precursor cells?

A

Cells that have hematopoietic lineage are morphologically identifiable

59
Q

For Erythropoiesis, the most primitive stem cell —— differentiate into—— that differentiate into —— which is called ———

A

PPSC, Myeloid CSC, erythroid progenitor cells, BFU-E

60
Q

The biochemical identification of an erythroid progenitor cell is what?

A

The appearance of a small quantity of ABO blood group antigens on the surface of the membrane of the cells

61
Q

What mediates platelet adhesion?

A

GP Ib receptor

62
Q

Gp Ib receptor is able to attach to?

A

Adhesive protein called VWF

63
Q

VWF attaches to?

A

Sub-endothelial surface

64
Q

Platelet adhesion requires?

A

VWF
GP Ib receptor on platelet
Platelets

65
Q

Platelet aggregation requires?

A

Fibrinogen and GP IIb/IIIa receptor

66
Q

Deficiency of GP Ib receptor

A

Bernard Soulier syndrome

67
Q

Glanzmanns disease is as a result of deficiency of what receptor?

A

GP IIb/IIIa

68
Q

The coating of bacteria by corresponding anti bodies is called?

A

Opsonization

Hematology (3 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions