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Flashcards in Hemostasis Deck (26)
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1
Q

What is the receptor for collagen?

A

integrin α2β1

2
Q

What three hormones are found in dense granules?

A

histamine, serotonin, epinephrine

3
Q

What are the four constituents of α-granules?

A

vWF, fibrinogen, fibronectin, Factor V

4
Q

What two clotting factors are released by desmopressin?

A

vWF and VIII

5
Q

What bleeding disorder can have giant platelets?

A

Bernard-Soulier

6
Q

What is the function of gamma-carboxyglutamate?

A

bind calcium for clotting

7
Q

What clotting factor activates Factor XIII? What type of enzymatic activity does this clotting factor possess?

A

thrombin

transglutaminase

8
Q

Factor XIII connects which two amino acids? Via what bond?

A

lysine and glutamine

amide

9
Q

What is the mode of inheritance for Hemophilia A and B?

A

X-linked recessive

10
Q

What type of molecule is Antithrombin III?

A

Serpin

11
Q

TFPI inhibits which two coagulation cascade proteins?

A

VIIa and Xa

12
Q

What stimulates the release of tPA?

A

Activated Protein C

13
Q

Which two proteins directly inhibit plasmin?

A

α2-antiplasmin

α2-macroglobulin

14
Q

What protein does streptokinase activate?

A

plasminogen

15
Q

What is the first prostaglandin involved in clotting? Second? Final?

A

first = G2

second = H2

third = TXA2

16
Q

Does serotonin release from platelets act to vasoconstrict or vasodilate?

A

vasoconstrict

17
Q

What two clotting factors does thrombin activate?

A

five and eight

18
Q

Regarding coagulation, what is the function of kallikrein?

A

activate additional factor twelve

19
Q

β-hemolytic streptococci provides what plasminogen activator?

A

streptokinase

20
Q

What cell type releases TFPI?

A

endothelial

21
Q

According to Wilson, what three coagulation factors require thrombin for their activation?

A

five, “seven” and eight

22
Q

What protein does APC inactivate?

A

plasinogen activator inhibitor

23
Q

Other than plasmin, tPA has a high affinity for what protein?

A

fibrin

24
Q

What is the most common platelet/clotting disorder ? How is this disease often identified?

A

vWF disorder

dental work

25
Q

Which clotting factors are stable when bound to cell membrane?

A

seven, nine and ten

26
Q

What amino acid substitution is present in Factor V Leiden disease?

A

arginine to glutamine