Hemostasis

Question 1

Goal + 4 steps of 1˚ Hemostasis

Answer 1

Goal: weak plt plug

Steps:

1. transient vasoC
2. plt adhesion (vWF , Gp1b plt adhesion)
3. plt degranulation (release ADP, TxA2)
4. WEAK plt aggregn (GP2B/3a + fibrinogen)

Question 2

1. ADP released from _____ & promotes ____
2. TxA2 is synthesized by ___ and promotes _____
3. vwf released from _____ (endoth cells) and ____ plts

Answer 2

1. dense granules; G2b/3a rcps on plts
2. plt cyclooxygenase (COX); plt aggregn
3. Weibel Palade bodies (also stores P selection); ∝ granules

Question 3

immune thrombocytic purpura (ITP) (3 chr)

1˚ or 2˚ Hemostasis Dz?

Answer 3

• splenic IgG Abs against plt (eg GP2b/3a)
• most common
• mø activity –> thrombocytopenia
• primary hemostasis dz

Question 4

Acute ITP (3 chr)

Answer 4

1. in children
2. self limited (weeks)
3. post inftection/vax

Question 5

Chronic ITP (3 chrs)

Answer 5

1. in adults (usually childbearing women)
2. ± 1˚ or 2˚(SLE)
3. ± cross placenta (short lived thrombocytopenia)

Question 6

Lab findings ITP (3)

Answer 6

1. dec pt
2. normal PT/PTT
3. inc MGKs in BM

Question 7

Treat ITP w/

Answer 7

1. coriticosteroids (good for kids)
2. IVIG (shortlived)
3. splenectomy (1˚ Ab + plt destruction source)

Question 8

Microangiopathic Hemolytic Anemia (MHA) is chr by ______ (3) and seen in ___ (2)

1˚ or 2˚ Hemostasis Dz?

Answer 8

• small bvs
• plt consumed in ↑ microthrombi
• RBCs sheared ➔ HemAn + shistocytes

_________________

• TTP (thrombotic thrombocytopenic purpura)
• HUS (hemolytic uremic syndrome)

_____________________

1˚ Hemostasis dz

Question 9

TTP dt _____ which cleaves vWF for degradation. vWF accumulation leades to microthrombi.

1˚ or 2˚ Hemostasis Dz?

Answer 9

decreased ADAMTS13

________

1˚ Hemostasis Dz