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Physiology > Hemostasis, chap 36 guyton 11th (P457) > Flashcards

Hemostasis, chap 36 guyton 11th (P457) Flashcards

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0
Q

Events in hemostasis are?

A
  1. Vascular construction
  2. Formation of a PLATELET PLUG
  3. formation of BLOOD CLOT
  4. Growth of FIBROUS TISSUE

P457

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1
Q

It means prevention of blood loss.

A

HEMOSTASIS

P457

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2
Q

Immediate result of blood vessel trauma?

A

Contraction of smooth muscle in BV wall.

P457

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3
Q

Results of smooth muscle contraction (in vascular constriction) are?

A
  1. Local myogenic SPASM
  2. Local AUTOCOID factors
  3. Nervous reflexes

P457

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4
Q

Vasoconstrictor produced by platelets

A

Thromboxane A2 (A sub 2)

P457

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5
Q

I’m a PLATELET, what’s INSIDE me? (8)

A

(FOR CONTACTION)

  1. Actin
  2. Myosin
  3. Thrombosthenin

(ENZYME SYNTHESIS, CA++ STORAGE)

  1. ER
  2. Golgi apparatus

(ENERGY)
6. MITOCHONDRIA

(COAGULATION)
7. Fibrin-stabilizing factor

(MULTIPLICATION OF ENTHOTHELIAL CELLS, VASCUALR SMOOTH MUSCLE AND FIBROBLAST)
8. Growth factor

P457

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6
Q

PLATELET: feel my MEMBRANE, what’s with it?

A
  1. GLYCOPROTEINS

( repulsion and adhesion)

  1. PHOSPHOLIPIDS

( activation)

P458

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7
Q

Platelet plug process:

A
  1. DAMAGE
  2. PLATELET CONTACT
  3. CHARACTERISTIC CHANGE of Platelet
    • swell
    • protruding pseudopods
    • become sticky
    • ADP secretion
    • Thromboxane A2 secretion
  4. Other platelet activation
    • with the use of ADP and THROMBOXANE A2
  5. Formation of FIBRIN THREAD
    • already part of blood coagulation

P458

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8
Q

Characteristic change in platelet during platelet plug formation:

A
  • swell
    • protruding pseudopods
    • become sticky
    • ADP secretion
    • Thromboxane A2 secretion

P458

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9
Q

Contactile proteins inside platelets (3):

A
  1. Actin
  2. Myosin
  3. Thrombosthenin

P457

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10
Q

T or F: small platelet count can cause formation of thousands of small hemorrhagic areas under skin throughout the internal tissue.

A

True

P458

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11
Q

Initiators of blood clotting:

A

Activator substances from

  1. PLATELETS
  2. Blood proteins

P458

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12
Q

2 possible courses AFTER blood clot, what’s more usual?

A
  1. Invasion of Fibroblast (usual)
  2. Dissolve

P458

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13
Q

What promotes the invasion of fibroblast after blood clot?

A

GROWTH FACTORS

from platelets

P459

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14
Q

BLOOD CLOT formation:

A
  1. Severed vessel
  2. Platelets agglutinate
  3. Fibrin appears
  4. Fibrin clot forms
  5. Clot retraction occurs

P458

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15
Q

Substances that PROMOTES COAGULATION:

A

PROCOAGULANTS

P459

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16
Q

Substances that INHIBITS COAGULATION:

A

ANTICOAGULANTS

P459

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17
Q

T or F: Procoagulations dominate the blood stream in normal conditions.

A

FALSE,

Anticoagulants dominate

P459

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18
Q

Factor I synonym

A

FIBIRNOGEN

P459

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19
Q

Factor II synonym

A

PROTHROMBIN

P459

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20
Q

Factor III synonym

A

TISSUE FACTOR

TISSUE THROMBOPLASTIN

P459

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21
Q

Factor IV synonym

A

CALCIUM

P459

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22
Q

Factor V synonym (3)

A

PROACCELERIN

LABILE FACTOR

AC- Globulin

P459

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23
Q

Factor VII synonym

A

SPCA

PROCONVERTIN

STABLE FACTOR

P459

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24
Factor VIII synonym
AHF AHG ANTIHEMOPHILIC FACTOR A P459
25
Factor IX synonym
PTC CHRISTMAS FACTOR P459
26
Factor X synonym
STUART FACTOR STUART-PROWER FACTOR P459
27
Factor XI synonym
PTA ANTIHEMOPHILIC FACTOR C P459
28
Factor XII synonym
HAGEMAN FACTOR P459
29
Factor XIII synonym
FIBRIN-STABILIZING FACTOR P459
30
Prekallikrein synonym
FLETCHER FACTOR P459
31
High-molecular-weight kininogen synonym
FITZGERALD FACTOR HMWK P459
32
T or F: platelet is a clotting factor.
TRUE P459
33
3 essential steps of blood coagulation
1. Formation of PROTHROMBIN ACTIVATOR 2. PROTHROMBIN to THROMBIN 3. FIBRINOGEN to FIBRIN P459
34
What enmesh platelets, blood cells and plasma to form clot?
FIBRIN FIBERS P459
35
What is the rate-limiting factor in blood coagulation?
Formation of PROTHROMBIN ACTIVATOR P459
36
T or F: MUCH of the prothrombin first attaches to PROTHROMBIN RECEPTOR of PLATELETS ALREADY BOUND in damaged tissues.
TRUE P459
37
What is the Organ that continually produces prothrombin?
LIVER P460
38
What are the Vitamin k dependent factors?
FACTORS 2,7,9,10 P469,lecture
39
T or F: Ca++ aids fibrin Polymerization
TRUE P459
40
What is the clotting factor that cause covalent bond between fibrin monomers and cross linkages between fibrin fibers?
FACTOR XIII or FIBRIN-STABILIZING FACTOR P459,P460
41
T of F: fibrin cannot polymerize without the aid of fibrin-stabilizing factor.
FALSE it can polymerize but only by HYDROGEN BONDING. Therefore weak. P460
42
Term used to refer to the fluid expressed from the clot. Fluid lacking clotting factors
SERUM P460
43
T or F: platelets are involved in binding of fibrin fibers
TRUE P460
44
Initiates prothrombin activator (3)
1. Trauma to VASCULAR WALL 2. Trauma to the BLOOD 3. Blood and damaged wall contact P461
45
2 ways in prothrombin formation
1. EXTRINSIC PATHWAY 2. INTRINSIC PATHWAYS P461
46
What are responsible for activation of Stuart factor in extrinsic pathway?
1. FACTOR VII 2. FACTOR III lipoprotein. 3. CALCIUM IONS P462
47
Whats Specific part of Tissue factor involved on activation of Factor X?
LIPOPROTEIN COMPLEX P462
48
T or F: Prothrombin activator is a complex of different clotting factors.
TRUE factors Xa, V/Va, III P462
49
What constitutes prothrombin activator?
1. FACTOR Xa 2. FACTOR III phospholipid 3. FACTOR V phospholipid 3. PLATELET phospholipid 5. Ca++ ( in performing function) P462
50
What is the actual protease that causes splitting of prothrombin to form thrombin?
Factor Xa P462
51
What part of prothrombin activator is specifically affected by thrombin in vicious circle of clot formation?
FACTOR V P462
52
2 clotting factors affected by trauma in intrinsic pathway:
1. FACTOR XII 2. PLATELETS P463
53
T or F: activation of factor XI requires Fitzgerald factor.
TRUE P463
54
What are responsible for activation of Stuart factor in intrinsic pathway?
1. FACTOR IXa 2. FACTOR VIIIa 3. PLATELET phospholipid 4. FACTOR 3 P463
55
What Clotting factor is missing when a person has CLASSIC HEMOPHILIA?
FACTOR VIII P463
56
what Clotting factor is missing when a person has THROMBOCYTOPENIA?
PLATELETS P463
57
T or F: the role of factor Xa in prothrombin cleaving in extrinsic and intrinsic pathway is different.
FALSE it is the same. P463
58
T or F: deionization and precipitation of ca++ helps in preventing blood clot if blood is outside the body.
TRUE P463
59
Which clotting pathway is faster?
EXTRINSIC PATHWAY! It occurs in as fast as 15 seconds while intrinsic pathway usually requires 1-6 minutes. P463
60
Factors needed in prevention of blood clot: (3)
1. SMOOTHNESS 2. GLYCOCALYX layer 3. THROMBOMODULIN P463
61
What activates protein C?
THROMBOMODULIN-THROMBIN COMPLEX P463
62
T or F: Clotting factors V and VIII can be inactivated by protein c.
TRUE P463
63
T or F: fibrin fibers function as Procoagulant.
FALSE! it's an ANTICOAGULANT!! Together with an P463
64
T or F: Heparin by itself does not have anticoagulant effect.
TRUE! It's anticoagulant effects rely on presence of anti thrombin III which it increases the function into hundred to thousand folds. P464
65
T or F: Production of heparin is a function of mast cell.
TRUE! Also BASOPHILS! P464
66
This digest fibrin fibers, fibrinogen, and Factors II,V,VIII,XII.
PLASMIN! P464
67
What Digestive enzyme is resembled by plasmin?
TRYPSIN From pancreatic secretion. p464
68
What converts plasminogen to plasmin?
TISSUE PLASMINOGEN ACTIVATOR (t-PA) P464
69
T or F: Protein C is a clotting factor.
TRUE! Wala sa table pero mentioned as one in page 464 under vit. K deficiency. P464
70
Enumerate vitamin K dependent clotting factors!
1. FACTOR II 2. FACTOR VII 3. FACTOR IX 4. FACTOR X 5. PROTEIN C P464
71
T or F: hemophilia is an x-linked disease.
TRUE! P465
72
What Component of factor VIII that is most important in the intrinsic pathway.
SMALL component P465
73
Von Willebrand's disease is caused by what? Be specific.
Loss of LARGE component of Factor VIII P465
74
Term that refers to the presence of very low numbers of platelets in circulating blood.
THROMBOCYTOPENIA P465
75
What disease has The display of purplish blotches as a result of platelet defficiency?
THROMBOCYTOPENIC PURPURA P465
76
What is an abnormal clot that develops in a blood vessel?
THROMBUS! P465
77
What is the term used to refer to freely flowing blood clots in blood stream?
EMBOLI! P465
78
Twofold usual cause thromboembolic conditions.
1. Roughed endothelial surface of a vessel | 2. Very slow blood flow
79
Genetically engendered activator used in treatment of intravascular clots
t-PA P466
80
Events in hemostasis are?
1. Vascular construction 2. Formation of a PLATELET PLUG 3. formation of BLOOD CLOT 4. Growth of FIBROUS TISSUE P457
81
Immediate result of blood vessel trauma?
Contraction of smooth muscle in BV wall. P457
82
Results of smooth muscle contraction (in vascular constriction) are?
1. Local myogenic SPASM 2. Local AUTOCOID factors 3. Nervous reflexes P457
83
Vasoconstrictor produced by platelets
Thromboxane A2 (A sub 2) P457
84
I'm a PLATELET, what's INSIDE me? (8)
(FOR CONTACTION) 1. Actin 2. Myosin 3. Thrombosthenin (ENZYME SYNTHESIS, CA++ STORAGE) 4. ER 5. Golgi apparatus (ENERGY) 6. MITOCHONDRIA (COAGULATION) 7. Fibrin-stabilizing factor (MULTIPLICATION OF ENTHOTHELIAL CELLS, VASCUALR SMOOTH MUSCLE AND FIBROBLAST) 8. Growth factor P457
85
PLATELET: feel my MEMBRANE, what's with it?
1. GLYCOPROTEINS ( repulsion and adhesion) 2. PHOSPHOLIPIDS ( activation) P458
86
Platelet plug process:
1. DAMAGE 2. PLATELET CONTACT 3. CHARACTERISTIC CHANGE of Platelet - swell - protruding pseudopods - become sticky - ADP secretion - Thromboxane A2 secretion 4. Other platelet activation - with the use of ADP and THROMBOXANE A2 5. Formation of FIBRIN THREAD - already part of blood coagulation P458
87
Characteristic change in platelet during platelet plug formation:
- swell - protruding pseudopods - become sticky - ADP secretion - Thromboxane A2 secretion P458
88
Contactile proteins inside platelets (3):
1. Actin 2. Myosin 3. Thrombosthenin P457
89
T or F: small platelet count can cause formation of thousands of small hemorrhagic areas under skin throughout the internal tissue.
True P458
90
Initiators of blood clotting:
Activator substances from 1. PLATELETS 2. Blood proteins P458
91
2 possible courses AFTER blood clot, what's more usual?
1. Invasion of Fibroblast (usual) 2. Dissolve P458
92
What promotes the invasion of fibroblast after blood clot?
GROWTH FACTORS from platelets P459
93
BLOOD CLOT formation:
1. Severed vessel 2. Platelets agglutinate 3. Fibrin appears 4. Fibrin clot forms 5. Clot retraction occurs P458
94
Substances that PROMOTES COAGULATION:
PROCOAGULANTS P459
95
Substances that INHIBITS COAGULATION:
ANTICOAGULANTS P459
96
T or F: Procoagulations dominate the blood stream in normal conditions.
FALSE, Anticoagulants dominate P459
97
Factor I synonym
FIBIRNOGEN P459
98
Factor II synonym
PROTHROMBIN P459
99
Factor III synonym
TISSUE FACTOR TISSUE THROMBOPLASTIN P459
100
Factor IV synonym
CALCIUM P459
101
Factor V synonym (3)
PROACCELERIN LABILE FACTOR AC- Globulin P459
102
Factor VII synonym
SPCA PROCONVERTIN STABLE FACTOR P459
103
Factor VIII synonym
AHF AHG ANTIHEMOPHILIC FACTOR A P459
104
Factor IX synonym
PTC CHRISTMAS FACTOR P459
105
Factor X synonym
STUART FACTOR STUART-PROWER FACTOR P459
106
Factor XI synonym
PTA ANTIHEMOPHILIC FACTOR C P459
107
Factor XII synonym
HAGEMAN FACTOR P459
108
Factor XIII synonym
FIBRIN-STABILIZING FACTOR P459
109
Prekallikrein synonym
FLETCHER FACTOR P459
110
High-molecular-weight kininogen synonym
FITZGERALD FACTOR HMWK P459
111
T or F: platelet is a clotting factor.
TRUE P459
112
3 essential steps of blood coagulation
1. Formation of PROTHROMBIN ACTIVATOR 2. PROTHROMBIN to THROMBIN 3. FIBRINOGEN to FIBRIN P459
113
What enmesh platelets, blood cells and plasma to form clot?
FIBRIN FIBERS P459
114
What is the rate-limiting factor in blood coagulation?
Formation of PROTHROMBIN ACTIVATOR P459
115
T or F: MUCH of the prothrombin first attaches to PROTHROMBIN RECEPTOR of PLATELETS ALREADY BOUND in damaged tissues.
TRUE P459
116
What is the Organ that continually produces prothrombin?
LIVER P460
117
What are the Vitamin k dependent factors?
FACTORS 2,7,9,10 P469,lecture
118
T or F: Ca++ aids fibrin Polymerization
TRUE P459
119
What is the clotting factor that cause covalent bond between fibrin monomers and cross linkages between fibrin fibers?
FACTOR XIII or FIBRIN-STABILIZING FACTOR P459,P460
120
T of F: fibrin cannot polymerize without the aid of fibrin-stabilizing factor.
FALSE it can polymerize but only by HYDROGEN BONDING. Therefore weak. P460
121
Term used to refer to the fluid expressed from the clot. Fluid lacking clotting factors
SERUM P460
122
T or F: platelets are involved in binding of fibrin fibers
TRUE P460
123
Initiates prothrombin activator (3)
1. Trauma to VASCULAR WALL 2. Trauma to the BLOOD 3. Blood and damaged wall contact P461
124
2 ways in prothrombin formation
1. EXTRINSIC PATHWAY 2. INTRINSIC PATHWAYS P461
125
What are responsible for activation of Stuart factor in extrinsic pathway?
1. FACTOR VII 2. FACTOR III lipoprotein. 3. CALCIUM IONS P462
126
Whats Specific part of Tissue factor involved on activation of Factor X?
LIPOPROTEIN COMPLEX P462
127
T or F: Prothrombin activator is a complex of different clotting factors.
TRUE factors Xa, V/Va, III P462
128
What constitutes prothrombin activator?
1. FACTOR Xa 2. FACTOR III phospholipid 3. FACTOR V phospholipid 3. PLATELET phospholipid 5. Ca++ ( in performing function) P462
129
What is the actual protease that causes splitting of prothrombin to form thrombin?
Factor Xa P462
130
What part of prothrombin activator is specifically affected by thrombin in vicious circle of clot formation?
FACTOR V P462
131
2 clotting factors affected by trauma in intrinsic pathway:
1. FACTOR XII 2. PLATELETS P463
132
T or F: activation of factor XI requires Fitzgerald factor.
TRUE P463
133
What are responsible for activation of Stuart factor in intrinsic pathway?
1. FACTOR IXa 2. FACTOR VIIIa 3. PLATELET phospholipid 4. FACTOR 3 P463
134
What Clotting factor is missing when a person has CLASSIC HEMOPHILIA?
FACTOR VIII P463
135
what Clotting factor is missing when a person has THROMBOCYTOPENIA?
PLATELETS P463
136
T or F: the role of factor Xa in prothrombin cleaving in extrinsic and intrinsic pathway is different.
FALSE it is the same. P463
137
T or F: deionization and precipitation of ca++ helps in preventing blood clot if blood is outside the body.
TRUE P463
138
Which clotting pathway is faster?
EXTRINSIC PATHWAY! It occurs in as fast as 15 seconds while intrinsic pathway usually requires 1-6 minutes. P463
139
Factors needed in prevention of blood clot: (3)
1. SMOOTHNESS 2. GLYCOCALYX layer 3. THROMBOMODULIN P463
140
What activates protein C?
THROMBOMODULIN-THROMBIN COMPLEX P463
141
T or F: Clotting factors V and VIII can be inactivated by protein c.
TRUE P463
142
T or F: fibrin fibers function as Procoagulant.
FALSE! it's an ANTICOAGULANT!! Together with an P463
143
T or F: Heparin by itself does not have anticoagulant effect.
TRUE! It's anticoagulant effects rely on presence of anti thrombin III which it increases the function into hundred to thousand folds. P464
144
T or F: Production of heparin is a function of mast cell.
TRUE! Also BASOPHILS! P464
145
This digest fibrin fibers, fibrinogen, and Factors II,V,VIII,XII.
PLASMIN! P464
146
What Digestive enzyme is resembled by plasmin?
TRYPSIN From pancreatic secretion. p464
147
What converts plasminogen to plasmin?
TISSUE PLASMINOGEN ACTIVATOR (t-PA) P464
148
T or F: Protein C is a clotting factor.
TRUE! Wala sa table pero mentioned as one in page 464 under vit. K deficiency. P464
149
Enumerate vitamin K dependent clotting factors!
1. FACTOR II 2. FACTOR VII 3. FACTOR IX 4. FACTOR X 5. PROTEIN C P464
150
T or F: hemophilia is an x-linked disease.
TRUE! P465
151
What Component of factor VIII that is most important in the intrinsic pathway.
SMALL component P465
152
Von Willebrand's disease is caused by what? Be specific.
Loss of LARGE component of Factor VIII P465
153
Term that refers to the presence of very low numbers of platelets in circulating blood.
THROMBOCYTOPENIA P465
154
What disease has The display of purplish blotches as a result of platelet defficiency?
THROMBOCYTOPENIC PURPURA P465
155
What is an abnormal clot that develops in a blood vessel?
THROMBUS! P465
156
What is the term used to refer to freely flowing blood clots in blood stream?
EMBOLI! P465
157
Twofold usual cause thromboembolic conditions.
1. Roughed endothelial surface of a vessel | 2. Very slow blood flow
158
Genetically engendered activator used in treatment of intravascular clots
t-PA P466
159
Events in hemostasis are?
1. Vascular construction 2. Formation of a PLATELET PLUG 3. formation of BLOOD CLOT 4. Growth of FIBROUS TISSUE P457
160
Immediate result of blood vessel trauma?
Contraction of smooth muscle in BV wall. P457
161
Results of smooth muscle contraction (in vascular constriction) are?
1. Local myogenic SPASM 2. Local AUTOCOID factors 3. Nervous reflexes P457
162
Vasoconstrictor produced by platelets
Thromboxane A2 (A sub 2) P457
163
I'm a PLATELET, what's INSIDE me? (8)
(FOR CONTACTION) 1. Actin 2. Myosin 3. Thrombosthenin (ENZYME SYNTHESIS, CA++ STORAGE) 4. ER 5. Golgi apparatus (ENERGY) 6. MITOCHONDRIA (COAGULATION) 7. Fibrin-stabilizing factor (MULTIPLICATION OF ENTHOTHELIAL CELLS, VASCUALR SMOOTH MUSCLE AND FIBROBLAST) 8. Growth factor P457
164
PLATELET: feel my MEMBRANE, what's with it?
1. GLYCOPROTEINS ( repulsion and adhesion) 2. PHOSPHOLIPIDS ( activation) P458
165
Platelet plug process:
1. DAMAGE 2. PLATELET CONTACT 3. CHARACTERISTIC CHANGE of Platelet - swell - protruding pseudopods - become sticky - ADP secretion - Thromboxane A2 secretion 4. Other platelet activation - with the use of ADP and THROMBOXANE A2 5. Formation of FIBRIN THREAD - already part of blood coagulation P458
166
Characteristic change in platelet during platelet plug formation:
- swell - protruding pseudopods - become sticky - ADP secretion - Thromboxane A2 secretion P458
167
Contactile proteins inside platelets (3):
1. Actin 2. Myosin 3. Thrombosthenin P457
168
T or F: small platelet count can cause formation of thousands of small hemorrhagic areas under skin throughout the internal tissue.
True P458
169
Initiators of blood clotting:
Activator substances from 1. PLATELETS 2. Blood proteins P458
170
2 possible courses AFTER blood clot, what's more usual?
1. Invasion of Fibroblast (usual) 2. Dissolve P458
171
What promotes the invasion of fibroblast after blood clot?
GROWTH FACTORS from platelets P459
172
BLOOD CLOT formation:
1. Severed vessel 2. Platelets agglutinate 3. Fibrin appears 4. Fibrin clot forms 5. Clot retraction occurs P458
173
Substances that PROMOTES COAGULATION:
PROCOAGULANTS P459
174
Substances that INHIBITS COAGULATION:
ANTICOAGULANTS P459
175
T or F: Procoagulations dominate the blood stream in normal conditions.
FALSE, Anticoagulants dominate P459
176
Factor I synonym
FIBIRNOGEN P459
177
Factor II synonym
PROTHROMBIN P459
178
Factor III synonym
TISSUE FACTOR TISSUE THROMBOPLASTIN P459
179
Factor IV synonym
CALCIUM P459
180
Factor V synonym (3)
PROACCELERIN LABILE FACTOR AC- Globulin P459
181
Factor VII synonym
SPCA PROCONVERTIN STABLE FACTOR P459
182
Factor VIII synonym
AHF AHG ANTIHEMOPHILIC FACTOR A P459
183
Factor IX synonym
PTC CHRISTMAS FACTOR P459
184
Factor X synonym
STUART FACTOR STUART-PROWER FACTOR P459
185
Factor XI synonym
PTA ANTIHEMOPHILIC FACTOR C P459
186
Factor XII synonym
HAGEMAN FACTOR P459
187
Factor XIII synonym
FIBRIN-STABILIZING FACTOR P459
188
Prekallikrein synonym
FLETCHER FACTOR P459
189
High-molecular-weight kininogen synonym
FITZGERALD FACTOR HMWK P459
190
T or F: platelet is a clotting factor.
TRUE P459
191
3 essential steps of blood coagulation
1. Formation of PROTHROMBIN ACTIVATOR 2. PROTHROMBIN to THROMBIN 3. FIBRINOGEN to FIBRIN P459
192
What enmesh platelets, blood cells and plasma to form clot?
FIBRIN FIBERS P459
193
What is the rate-limiting factor in blood coagulation?
Formation of PROTHROMBIN ACTIVATOR P459
194
T or F: MUCH of the prothrombin first attaches to PROTHROMBIN RECEPTOR of PLATELETS ALREADY BOUND in damaged tissues.
TRUE P459
195
What is the Organ that continually produces prothrombin?
LIVER P460
196
What are the Vitamin k dependent factors?
FACTORS 2,7,9,10 P469,lecture
197
T or F: Ca++ aids fibrin Polymerization
TRUE P459
198
What is the clotting factor that cause covalent bond between fibrin monomers and cross linkages between fibrin fibers?
FACTOR XIII or FIBRIN-STABILIZING FACTOR P459,P460
199
T of F: fibrin cannot polymerize without the aid of fibrin-stabilizing factor.
FALSE it can polymerize but only by HYDROGEN BONDING. Therefore weak. P460
200
Term used to refer to the fluid expressed from the clot. Fluid lacking clotting factors
SERUM P460
201
T or F: platelets are involved in binding of fibrin fibers
TRUE P460
202
Initiates prothrombin activator (3)
1. Trauma to VASCULAR WALL 2. Trauma to the BLOOD 3. Blood and damaged wall contact P461
203
2 ways in prothrombin formation
1. EXTRINSIC PATHWAY 2. INTRINSIC PATHWAYS P461
204
What are responsible for activation of Stuart factor in extrinsic pathway?
1. FACTOR VII 2. FACTOR III lipoprotein. 3. CALCIUM IONS P462
205
Whats Specific part of Tissue factor involved on activation of Factor X?
LIPOPROTEIN COMPLEX P462
206
T or F: Prothrombin activator is a complex of different clotting factors.
TRUE factors Xa, V/Va, III P462
207
What constitutes prothrombin activator?
1. FACTOR Xa 2. FACTOR III phospholipid 3. FACTOR V phospholipid 3. PLATELET phospholipid 5. Ca++ ( in performing function) P462
208
What is the actual protease that causes splitting of prothrombin to form thrombin?
Factor Xa P462
209
What part of prothrombin activator is specifically affected by thrombin in vicious circle of clot formation?
FACTOR V P462
210
2 clotting factors affected by trauma in intrinsic pathway:
1. FACTOR XII 2. PLATELETS P463
211
T or F: activation of factor XI requires Fitzgerald factor.
TRUE P463
212
What are responsible for activation of Stuart factor in intrinsic pathway?
1. FACTOR IXa 2. FACTOR VIIIa 3. PLATELET phospholipid 4. FACTOR 3 P463
213
What Clotting factor is missing when a person has CLASSIC HEMOPHILIA?
FACTOR VIII P463
214
what Clotting factor is missing when a person has THROMBOCYTOPENIA?
PLATELETS P463
215
T or F: the role of factor Xa in prothrombin cleaving in extrinsic and intrinsic pathway is different.
FALSE it is the same. P463
216
T or F: deionization and precipitation of ca++ helps in preventing blood clot if blood is outside the body.
TRUE P463
217
Which clotting pathway is faster?
EXTRINSIC PATHWAY! It occurs in as fast as 15 seconds while intrinsic pathway usually requires 1-6 minutes. P463
218
Factors needed in prevention of blood clot: (3)
1. SMOOTHNESS 2. GLYCOCALYX layer 3. THROMBOMODULIN P463
219
What activates protein C?
THROMBOMODULIN-THROMBIN COMPLEX P463
220
T or F: Clotting factors V and VIII can be inactivated by protein c.
TRUE P463
221
T or F: fibrin fibers function as Procoagulant.
FALSE! it's an ANTICOAGULANT!! Together with an P463
222
T or F: Heparin by itself does not have anticoagulant effect.
TRUE! It's anticoagulant effects rely on presence of anti thrombin III which it increases the function into hundred to thousand folds. P464
223
T or F: Production of heparin is a function of mast cell.
TRUE! Also BASOPHILS! P464
224
This digest fibrin fibers, fibrinogen, and Factors II,V,VIII,XII.
PLASMIN! P464
225
What Digestive enzyme is resembled by plasmin?
TRYPSIN From pancreatic secretion. p464
226
What converts plasminogen to plasmin?
TISSUE PLASMINOGEN ACTIVATOR (t-PA) P464
227
T or F: Protein C is a clotting factor.
TRUE! Wala sa table pero mentioned as one in page 464 under vit. K deficiency. P464
228
Enumerate vitamin K dependent clotting factors!
1. FACTOR II 2. FACTOR VII 3. FACTOR IX 4. FACTOR X 5. PROTEIN C P464
229
T or F: hemophilia is an x-linked disease.
TRUE! P465
230
What Component of factor VIII that is most important in the intrinsic pathway.
SMALL component P465
231
Von Willebrand's disease is caused by what? Be specific.
Loss of LARGE component of Factor VIII P465
232
Term that refers to the presence of very low numbers of platelets in circulating blood.
THROMBOCYTOPENIA P465
233
What disease has The display of purplish blotches as a result of platelet defficiency?
THROMBOCYTOPENIC PURPURA P465
234
What is an abnormal clot that develops in a blood vessel?
THROMBUS! P465
235
What is the term used to refer to freely flowing blood clots in blood stream?
EMBOLI! P465
236
Twofold usual cause thromboembolic conditions.
1. Roughed endothelial surface of a vessel | 2. Very slow blood flow
237
Genetically engendered activator used in treatment of intravascular clots
t-PA P466
238
Enzyme in the blood that destroys heparin
Heparinase
239
What is the usual bleeding time?
1-6 minutes P467
240
What is the usual clotting time?
6 - 10 minutes P467
241
What is the time requires for coagulation to take place?
PROTHROMBIN TIME P467
242
Usual prothrombin time?
12 seconds P467

Physiology (4 decks)

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