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Pharmacology - CVS > Heparins > Flashcards

Flashcards in Heparins Deck (12)
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1
Q

What are heparins commonly indicated for use in?

A
  • VTE
  • DVT
  • PE
2
Q

What is the mechanism of action of low molecular weight heparins?

A

Low molecular weight heparins inhibit the action of thrombin and factor Xa, but preferentially inhibit factor Xa.

3
Q

What is the mechanism of action of unfractionated heparins?

A

Unfractionated heparin (UFH) activates antithrombin that, in turn, inactivates clotting factor Xa and thrombin

4
Q

Why is LMWH preferred to unfractionated?

A

Requires no laboratory monitoring

5
Q

What are important adverse effects of heparins?

A
  • Bleeding
  • Injection site reactions
  • HIT
6
Q

When should anticoagluants be used with caution?

A
7
Q

What drugs can heparins interact with?

A

Warfarin

8
Q

What are examples of LMWH?

A
  • Enoxaparin
  • Dalteparin
9
Q

What do bloods do you need to do after commencing enoxaparin?

A

FBC - prior to treatment, and 1 week after

10
Q

When taking FBC when monitoring heparin use, what are you looking for?

A

Decreased platelets - could indicate development of HIT

11
Q

What should you do if someone is on heparin and develops thrombocytopenia?

A

Stop drug and seek specialist help immediately

12
Q

How are heparins administered?

A

Subcutaneous injection