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Flashcards in Hepatitis Deck (37):
1

what is the virus that infects the liver and describe it

hepatitis infects the liver primarily the hepatocytes where it replicates and liver damage comes from the virus itself as well as the host response. some acute some chronic

2

family, genome and virion of Hep A

family: picornavidae
genome: +ssRNA
virion: non enveloped

3

family genome and virion of Hep B

family: hepadnaviridae
genome: circular dsDNA
virion: enveloped

4

family, genome, and vision of Hep C

family: flavivivridae
genome: +ssRNA
virion: enveloped

5

family, genome, and vision of Hep D

family: deltaviridae
genome: -ssRNA
virion: enveloped

6

family, genome, and vision of Hep E

family: calciviridae
genome: +ssRNA
virion: nonenveloped

7

what Heps are nonenveloped

Hep E and Hep A

8

what Hep is similar to Polo virus

Hep A

9

what Hep is DNA genome and what kind?

Hep B is circular dsDNA

10

What Heps are transmitted via sex

ALL OF THEM!!

11

what Heps are transmitted via fecal oral

HEP A and E

12

what Heps are transmitted via vertical

Hep B, C, D

13

what Heps are transmitted via parenteral

All of them!!
Note: Hep A and E take a brief window of viremia to be passed from parent to child

14

what Hep causes the highest death rate from chronic liver disease

Hep C

15

what Hep is most prevalent in US population

Hep A

16

Describe Hep B including family, genome, virion

Hep B is from family hepadnaviridae, genome of circular dsDNA, is enveloped, and contains a reverse transcriptase polymerase (so a RNA intermediate is made)

17

Describe Biology of Hep B

cannot be grown in cell culture,
genome has RNA intermediate
cccDNA is template for transcription
requires liver specific transcription factors
produces empty particles (HBsAy)

18

What are the symptoms of Hep B virus

general malaise, anorexia, vomiting, fatigue, cough, serum like sickness
jaundice, elevated alanine transaminase (ALT) levels
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19

infection time a Hep B

incubated 30-180 days by sexual and drug use, recovered 3-4 months after jaundice

20

Chronic details of Hep B

chronic diseases occurs in 5 % of people presence of HBsAy in blood past 6 months is chronic.
marked by poor IgG response
sporadic episodes of hepatitis
cirrhosis of liver
increased risk for hepatocellular carcinoma

21

does Hep B increase or dec cancer risk

Hep B causes increase risk for cancer

22

Hep B prevention and control

Hep B vaccine!
vaccine is first recombinant vaccine, not effective for chronic
treatment for chronic infections: interferon alpha therapy, nucleoside analogs: adefovir, lamivudine, and tenofovir

23

Hep D description

Hep D is sub viral and needs HPV to replicate
rare in human
(other sub viral is AAV which requires adenovirus infection)
Hep D genome is RNA and encodes 1 protein!

24

what does Hep D require

Hep D requires HPV to replicate

25

Hep C virus biology

family: flaviviridae
genome: +ssRNA
virion: enveloped
produces proteins E1 and E2 for attachment and entry and has a C core
genome passed into cytoplasm.
the genome is a template for translation recognizes IRES

26

Hep C virus description

Hep C is a extra hepatic disease i.e. cryoglobulinemia which means antibody and virus complexes deposit in other tissues eliciting an immune response and subsequent tissue damage

27

Hep C chronic facts

Hep C has milder signs and symptoms than observed for Hep B but chronic infections are very common around 80%

28

Hep C prevention and treatment

NO VACCINE for Hep C
interferon alpha treatment can help reduce chronic infection

29

Hep A virus infection details and symptoms and treatment

Hep A virus infection from fecal contaminated food or water
moves from intestines to liver via portal system
incubation of 15-40 days.
symptoms: malaise, anorexia, vomiting, jaundice
lasts about 8 weeks
Prevention: vaccine (Havrix (live), Vaqta (inactivated vaccine)

30

Is Hep A more severe in adults or children and is there a vaccine

Hep A is more severe in adults than children and THERE IS a vaccine

31

Hep E virus

causes food borne and waterborne hep
similar to Hep A determined by serology, infection is life threatening in pregnant women

32

is there a vaccine for Hep E

NO HEP E VACCINE

33

What Heps cause chronic infections?

Hep B, C, and D

34

what Heps cause long term sequelae

Hep B and C
Hep exacerbates HBV

35

what Heps have long incubation periods? i.e. greater than 60 days

Hep B, C, and D

36

what Hep have short inoculation periods? Ie less than 60 days

Hep A and E

37

what is the one Hep that doesn't often cause asymptomatic infections but is possible

Hep D