Hepatitis

Question 1

Name 4 common symptoms of Hepatitis

Answer 1

Yellow Sclera / jaundice / dark urine / pale stools

Question 2

Hepatitis A virus is part of what family?

Answer 2

Picornaviridae

Question 3

Structure of Hepatitis A

Answer 3

Naked ssRNA

Icosahedral

27nm

Question 4

Incubation of Hepatitis A

Answer 4

10-50 day

Question 5

90% of cases of Hepatitis A are of what age?

Answer 5

5-15 years

Question 6

What sort of vaccine is given for Hepatitis A

Answer 6

Monovalent inactivated Vaccine

Question 7

Hepatitis B is part of what family?

Answer 7

Hepadnaviridae

Question 8

What is the structure of Hepatitis B

how many genotypes

Answer 8

Partial dsDNA

9 genotypes

Question 9

How many people are unaware of being infected with Hepatitis B? How many are infected at birth?

Answer 9

90%

75%

Question 10

Incubation time for hepatitis B?

Answer 10

30-180 days

Question 11

Name the 3 stages of hepaittis infection

Answer 11

Acute

Fulminant

Chronic

Question 12

Name 2 treatments for Hepatitis B

Answer 12

IF-a

Tenofovir

Question 13

Hepatitis D is what sort of virus?

Answer 13

subviral satellite

Question 14

Structure of Hepatitis D

Answer 14

Delta genus

ssRNA

35-37nm

Question 15

How many genotypes does hepatitis D have

Answer 15

3 genotypes

Question 16

What % of Hep B patients have Hep D?

Answer 16

5%

Question 17

What are the two complications of hepatitis D

Answer 17

Co-infection

Superinfection

Question 18

Hepatitis C is part of what family?

Answer 18

Flaviviridae

Question 19

Structure of hepatitis C

Answer 19

50nm

ssRNA enveloped

Question 20

How many genotypes of hepatitis C

Answer 20

7 genotypes

Question 21

How many are unaware of inefction of hepatitis C

Answer 21

80%

Question 22

Where is the majority of Hep C infections?

Whats happening in the UK?

Answer 22

Africa

Increased

Question 23

How many people are infected with Hep C in UK? Reference?

Answer 23

200,000 Gov 2018

Question 24

What is the incubation time for Hepatitis C

What 3 things can it lead to?

Answer 24

8 weeks

Mild liver disease //chronic hep (90%) // cirrhosis

Question 25

What Treatment can be given for hep C? What is the probability of relapse?

Answer 25

IFN a2b 50/50

Question 26

What sort of IFN can be given for Hep C

Answer 26

PEGylated IFNs

Question 27

Name a nucleoside analogue for Hepatitis C What does it do

Answer 27

Sofosbuvir Inhibit polymerase

Question 28

Name a protease inhibitor for hepatitis C

Answer 28

Simeprevir

Question 29

What family is hepatitis E part of

Answer 29

hepeviridae

Question 30

What is the structure of hep E

Answer 30

ssRNA 32-34nm

Question 31

What genotypes are present with hepatitis E How are these transmitted

Answer 31

G1 + G2 = faecal oral G3 + G4 = Zoonotic

Question 32

Hepatitis E is prevalent Where?

Answer 32

Endemic in developing countries

Question 33

What is the incubation of hepatitis E What normally happens to it

Answer 33

15-60 days acute infection = lifelong immunity as self limiting

Question 34

What age group is affected with hepatitis E

Answer 34

15-40

Question 35

What happens to immunosuppresed individuals with hepatitis E What happens to pregnant women with hepatitis E

Answer 35

Chronic Hepatitis Fulminant Hepatitis

Question 36

What genotype of hepatitis E has the highest mortality

Answer 36

G1

Question 37

Whats the treatment for hepatitis E

Answer 37

no vaccine available good sanitation Ribavinin

Question 38

Hepatitis G is part of what family like hepatitis C

Answer 38

Flaviviridae

Question 39

What does it do to do with HIV what does it not cause

Answer 39

decrease CXCR4 / CCR5 expression on CD4/CD19 B disease

Question 40

How many are infected with Hepatitis A

Answer 40

1.4 million

Question 41

How many are infected with Hepatitis B

Answer 41

257million

Question 42

How many are infected with Hepatitis D

Answer 42

15-20 million

Question 43

How many are infected with Hepatitis C

Answer 43

71 million

Question 44

How many are infected with Hepatitis E

Answer 44

20 million

Question 45

Who are generally affected by Hepatitis A?

Answer 45

Travellers

Question 46

What 2 hepatitis are transmitted by faecal oral?

Answer 46

A + E

Question 47

With hepatitis A, what is it always in terms of stages/

Answer 47

normally always acute not chronic

Question 48

With the diagnostics, what does a high IgM show?

Answer 48

Active infection

Question 49

What two viruses have been associated with hepatitis that are not direct causes?

Answer 49

Torque Teno Virus SEN-V

Question 50

TTV is associated with what % of hepatitis disease patients/

Answer 50

16-19%

Question 51

SEN-V is associated with what type of infection?

Answer 51

Co-infection of Hep . C

Question 52

How can you treat SEV-V?

Answer 52

IFN

Question 53

Structure of SEN-V

Answer 53

ssDNA