Hepatitis A and B Flashcards Preview

Internal Medicine 1: Hepatology > Hepatitis A and B > Flashcards

Flashcards in Hepatitis A and B Deck (23)
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1
Q

Hepatitis is transmitted via?

A

Feco-oral route

2
Q

Incubation period of hepatitis A?

A

30 days

3
Q

What does hepatitis A typically present as?

A

Icteric attack

4
Q

Does HAV cause chronic liver disease?

A

No, unlike HBV and HCV

5
Q

What is the lab for HAV?

A

antibody for HAV

6
Q

Hepatitis A is associated with an elevation in both?

A

Serum aminotransferase and bilirubin

7
Q

If bilirubin level remains elevated, what should be suspected?

A

Cholestaric liver disease

8
Q

What is the prognosis of hepatitis A?

A

Complete recovery between 3 months

9
Q

What is the most effective way of preventing HAV infection?

A

Sanitation, food safety, immunization practices

10
Q

What should we give to a person after having been exposed to HAV and unvaccinated?

A

The HAV immunoglobulin within 2 weeks

11
Q

Hepatitis B structurally is

A

Double-stranded DNA, unlike the RNA hepatitis A

12
Q

Transmission of HBV?

A

parentally/vertically, or horizontally via sex

13
Q

In the replication cycle of hepatitis B, cccDNA is formed, what’s that?

A

It serves as a template for RNA transcription

14
Q

Name both characteristic histological appearances of hepatitis B

A

Ground-glass appearance and sanded nuclei

15
Q

At what point is HBV considered to have progressed to chronic?

A

When HBV DNA and HBsAg persist in the serum longer than 6 months

16
Q

What is FCH, fibrosing cholestatic hepatitis?

A

Fatal form of liver injury with recurrent HBV infection seen in Liver Transplant patients

17
Q

What is FCH characterized by?

A

Deterioration in graft functions

18
Q

What do the liver chemistry results of chronic hepatitis B show?

A

Abnormal results

19
Q

What is the first serological marker of Acute hepatitis B?

A

HBsAg

20
Q

When do Anti-HBs appear?

A

After clearance of HBsAg

21
Q

In some patients there is a window period, what’s that?

A

When HBsAg is cleared but anti-HBs hadnt appeared, it could be months long

22
Q

What is the value of Anti-HBc IgM?

A

Diagnoses acute hepatitis B, could be the sole marker as well during the window period

23
Q

What is the biomarker that indicates HBV replication and infectivity?

A

HBeAg