Hepatitis A and B

Question 1

Hepatitis is transmitted via?

Answer 1

Feco-oral route

Question 2

Incubation period of hepatitis A?

Answer 2

30 days

Question 3

What does hepatitis A typically present as?

Answer 3

Icteric attack

Question 4

Does HAV cause chronic liver disease?

Answer 4

No, unlike HBV and HCV

Question 5

What is the lab for HAV?

Answer 5

antibody for HAV

Question 6

Hepatitis A is associated with an elevation in both?

Answer 6

Serum aminotransferase and bilirubin

Question 7

If bilirubin level remains elevated, what should be suspected?

Answer 7

Cholestaric liver disease

Question 8

What is the prognosis of hepatitis A?

Answer 8

Complete recovery between 3 months

Question 9

What is the most effective way of preventing HAV infection?

Answer 9

Sanitation, food safety, immunization practices

Question 10

What should we give to a person after having been exposed to HAV and unvaccinated?

Answer 10

The HAV immunoglobulin within 2 weeks

Question 11

Hepatitis B structurally is

Answer 11

Double-stranded DNA, unlike the RNA hepatitis A

Question 12

Transmission of HBV?

Answer 12

parentally/vertically, or horizontally via sex

Question 13

In the replication cycle of hepatitis B, cccDNA is formed, what’s that?

Answer 13

It serves as a template for RNA transcription

Question 14

Name both characteristic histological appearances of hepatitis B

Answer 14

Ground-glass appearance and sanded nuclei

Question 15

At what point is HBV considered to have progressed to chronic?

Answer 15

When HBV DNA and HBsAg persist in the serum longer than 6 months

Question 16

What is FCH, fibrosing cholestatic hepatitis?

Answer 16

Fatal form of liver injury with recurrent HBV infection seen in Liver Transplant patients

Question 17

What is FCH characterized by?

Answer 17

Deterioration in graft functions

Question 18

What do the liver chemistry results of chronic hepatitis B show?

Answer 18

Abnormal results

Question 19

What is the first serological marker of Acute hepatitis B?

Answer 19

HBsAg

Question 20

When do Anti-HBs appear?

Answer 20

After clearance of HBsAg

Question 21

In some patients there is a window period, what’s that?

Answer 21

When HBsAg is cleared but anti-HBs hadnt appeared, it could be months long

Question 22

What is the value of Anti-HBc IgM?

Answer 22

Diagnoses acute hepatitis B, could be the sole marker as well during the window period

Question 23

What is the biomarker that indicates HBV replication and infectivity?

Answer 23

HBeAg