Hepatitis B Flashcards Preview

Virology (UofA) > Hepatitis B > Flashcards

Flashcards in Hepatitis B Deck (11):
1

What cell types does it target?

Hepatocytes (liver cells)

2

What receptor is targeted?

NTCP

3

How does the virus enter the cell?

RM endocytosis

4

How does HBV present?

Jaundice, liver problems

5

How is the genome structured?

In relaxed circular DNA form (ie there is a nick in one strand)

6

What type of genome is HBV?

ds DNA

7

What occurs in the nucleus?

RC DNA converted to cccDNA (covalently closed circular DNA) and binds histones to create a stable plasmid type structure.

8

Where does budding occur?

Endoplasmic Reticulum

9

Does HBV contain reverse transcriptase?

Yes! It is carried inside the NC

10

What family is HBV in?

Hepadnaviridae

11

What TLRs would detect this virus?

TLR9 (for dsDNA genomes)