Hepatitis Viruses

Question 1

Signs and symptoms of all Hepatitis Viruses

Answer 1

• Episodes of fever, malaise, jaundice

- Elevated ALT and AST

Question 2

HAV morphology

Answer 2

RNA picornavirus

Question 3

Transmission of Hepatitis A

Answer 3

Oral-fecal (A and E are oral fecal transmission) remember, the vowels hit your bowels

Question 4

Characteristics of HAV

Answer 4

Usually asymptomatic and acute

Question 5

HBV morphology

Answer 5

DNA Hepadnavirus

Question 6

Transmission of HBV

Answer 6

Parenteral, Sexual, Maternal-fecal

Question 7

Hepatocellular Carcinoma risk with HBV?

Answer 7

Yes

Question 8

Hepatitis C virus morphology?

Answer 8

RNA flavivirus

Question 9

HCV transmission

Answer 9

Blood, Intravenous drug use

Question 10

Hepatocellular Carcinoma Risk with HCV

Answer 10

Yes, from chronic inflammation

Question 11

HDV morphology

Answer 11

RNA Delta virus

Question 12

HDV transmission

Answer 12

Parenteral, sexual, maternal-fetal

Question 13

HDV is DEPENDENT on HBV

Answer 13

ok

Question 14

HEV morphology

Answer 14

RNA hepevirus

Question 15

HEV transmission

Answer 15

Fecal Oral

Question 16

HEV things to remember

Answer 16

High mortality in pregnant women

Question 17

How do you diagnose HAV

Answer 17

IgM antibody to HAV (Anti-HAV IgM); best to detect active hep A

Question 18

Is there a chronic infection associated with HAV? Aka, can those infected become carriers?

Answer 18

NO

Question 19

Is there a chronic carrier state associated with HEV?

Answer 19

NO

Question 20

Is there a chronic carrier state associated with HCV

Answer 20

YES

Question 21

Tx for HCV

Answer 21

Interferon and Ribavirin

Question 22

WHen is the HBsAg present?

Answer 22

Remember that HBsAg represents the bad guys so anytime you have active infection, whether it be acute or chronic, you have HBsAg present.

So….present during acute active HBV, Chronic with low infectivity, chronic with high infectivity

Question 23

When is HBsAb present?

Answer 23

Remember that HBsAb is the good guy and is present when there is no HBsAg.

If you test positive for HBsAg it means that you either had an acute infection that resolved or you were vaccinated

Question 24

So how do you tell apart someone who had the vaccine from someone who had a resolved infection?

Answer 24

If the person was vaccinated, they will NOT have the HBcAb (core antibody) whereas if a person had an infection that resolved will have IgG core antibodies

Question 25

What does HBeAg mean?

Answer 25

The virus is replicating. Seen during acute phase and chronic phase with high infectivity

Question 26

What does HBeAb mean?

Answer 26

Low infectivity

Question 27

In viral hepatits

Answer 27

ALT > AST.....alcoholic = AST > ALT (A Scotch & Tonic)