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Flashcards in hepc- other, thyroid Deck (42)
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1
Q

Porphyria Cutanea Tarda (PCT)

• Caused by a deficiency in

A

uropoprhyrinogen decarboxylase (UROD);

2
Q

mechanisms transmission

A

inherited,sporadic or associated with Hepatitis C

3
Q

___ form may occur in association with HCV; in one study___% of patients with PCT
had HCV-antibodies

A

• Sporadic

82

4
Q

alcohol, estrogens, and polyhalogenated hydrocarbons

A

environmental triggers hep c

5
Q

facial hypertrichosis, hyper/hypopigmentation, skin fragility and sclerodermoid changes.

A

hcv

6
Q

The pathogenesis of HCV related PCT might be related to

A

decompartmentalization of iron stores resulting in formation of free iron radicals and oxidation of UROD

7
Q

phlebotomy to decrease iron load, interferon based regimens and
avoidance of triggering factors

A

Treatment hcv

8
Q

Lichen Planus

• Incidence of HCV in patients with lichen planus varies from

A

0.1% to 35%, depending on region

9
Q

• Treatment with interferon impact skin lesions

A

both worsening and improvement of the

10
Q

Polyarteritis Nodosa___% of patients were HCV+

A

12-31

11
Q

also associated with Hepatitis B

A

Polyarteritis nodosa

12
Q

Pruritus in chronic HCV infection

pathogenesis may be related to but not always a direct correlation

A

elevated bile salt levels that occur in the setting of liver failure

13
Q

cholestyramine, ursodeoxycholic acid, rifampin, naltrexone,

thalidomide, and UVA, UVB and interferon alpha

A

• Treatment regimens hcv pruritus

14
Q
  • Erythema nodosum
  • Erythema multiforme
  • Unilateral nevoid telangiectasia
  • Pyoderma gangrenosum
  • Vitiligo
  • Psoriasis
A

Uncommon Associations hep c

15
Q

Behçet’s syndrome
• Mooren corneal ulcers
• Granuloma annulare
• Disseminated superficial actinic porokeratosis

A

Uncommon Associations hep c

16
Q

alopecia, lichenoid eruption,
eczema, malar erythema, and local
cutaneous necrosis

A

most frequently reported

cutaneous findings with interferon

17
Q

combination of interferon α and ribavirin. T

A

Currently the best management of Hepatitis C is the

18
Q

cutaneous reactions were
more common in the group on combination interferon/ribavirin therapy therapy
T/F

A

T

19
Q

Thyroglossal Duct Cyst
Malignant degeneration to
papillary adenocarcinoma COMMON?

A

F. rare

20
Q

Metastases to the skin from a thyroid malignancy is rare but Most reported cases occur with

A

papillary adenocarcinoma

21
Q

Sipple syndrome, Sipple syndrome, autosomal dominant

MEN 2b/III

A

medullary thyroid carcinoma, pheochromocytoma, and parathyroid
hyperplasia/adenomas.

medullary thyroid carcinoma,
pheochromocytoma, marfanoid features, and gastrointestinal ganglioneuromatosis.

22
Q

Skin findings in Sipple syndrome are rare but may include

A

lichen or macular amyloidosis

23
Q

Sipple syndrome gene defect

A

RET proto-oncogene, which encodes a tyrosine receptor kinase.

24
Q

most common skin finding is mucosal neuromas.

A

MEN 2b/III

25
Q

Other associated cutaneous findings

include perioral and acral hypopigmentation, café-au-lait macules, and cirumoral lentigines

A

MEN 2b/III

26
Q

defect in the PTEN tumor supressor gene, which encodes a protein phosphatase.

A

Cowden’s syndrome (multiple hamartoma syndrome) autosomal dominant due to a

27
Q

trichilemmomas, acral keratoses, oral papillomas, acanthosis nigricans,
lipomas, facial dysmorphism and bony abnormalities and macrocephaly

A

Cowden’s syndrome

28
Q

increased risk of thyroid adenomas, thyroid goiter, thyroglossal duct cyst, and are at
andeveloping the follicular type of thyroid carcinoma.

fibrocystic breast disease, breast cancer and Lhermite Duclos disease (dysplastic
gangliocytoma of cerebellum)

A

Cowden’s syndrome

29
Q

• Thyroid dermopathy May progress to resemble

A

elephantiasis verrucosa nostra.

30
Q

Can occur in the euthyroid,

hypothyroid, or hyperthyroid state.

A

Thyroid dermopathy

31
Q

Thyroid dermopathy pathogenesis

A

increase in hyaluronic

acid in dermis.

32
Q

vitiligo, anetoderma, dermatitis herpetiformis, mid-dermal
elastolysis, herpes gestationis, pemphigus vulgaris, and
Sweet’s syndrome

A

• Cutaneous conditions associated with Grave’s disease

33
Q

thick, pale protuberant lips, delayed dentition, an enlarged
tongue, wide set eyes, a broad flat nose, dwarfism, cutis marmorata, cardiac defects,
gastrointestinal and skeletal defects

A

Congenital hypothyroidism

34
Q

binding of excess organic iodide in the thyroid gland with resultant inhibition of thyroid hormone synthesis.

occur in the setting of patients with

A

Wolff-Chaikoff effect WCE

35
Q
erythema nodosum (or
other inflammatory dermatoses) being treated with potassium iodide
A

Wolff-Chaikoff effect WCE

36
Q

• Thyroid dermopathy May progress to resemble

A

elephantiasis verrucosa nostra.

37
Q

Can occur in the euthyroid,

hypothyroid, or hyperthyroid state.

A

Thyroid dermopathy

38
Q

Thyroid dermopathy pathogenesis

A

increase in hyaluronic

acid in dermis.

39
Q

vitiligo, anetoderma, dermatitis herpetiformis, mid-dermal
elastolysis, herpes gestationis, pemphigus vulgaris, and
Sweet’s syndrome

A

• Cutaneous conditions associated with Grave’s disease

40
Q

thick, pale protuberant lips, delayed dentition, an enlarged
tongue, wide set eyes, a broad flat nose, dwarfism, cutis marmorata, cardiac defects,
gastrointestinal and skeletal defects

A

Congenital hypothyroidism

41
Q

binding of excess organic iodide in the thyroid gland with resultant inhibition of thyroid hormone synthesis.

occur in the setting of patients with

A

Wolff-Chaikoff effect WCE

42
Q
erythema nodosum (or
other inflammatory dermatoses) being treated with potassium iodide
A

Wolff-Chaikoff effect WCE