Herbicidal action, attributes and registration

Question 1

Chemistry, Mode of Action & Differences from Other Auxins

Through what herbicidal mode of action does Rinskor^TM active control weeds?

Answer 1

1. Synthetic auxin/plant growth regulator.
2. Rinskor mimics naturally occurring hormones by binding with specific auxin receptors in the cell’s nucleus.

Question 2

Chemistry, Mode of Action & Differences from Other Auxins

Rinskor^TM active possesses a totally new mode of action for weed management. True or False.

Answer 2

False. However Rinksor belong to a completely new family of chemistry, the Arylpicolinates, with a pattern and level of binding affinity with specific receptors that differentiates it from other synthetic auxin herbicides, by controlling a broader spectrum of weeds, having a favorable environmental and toxicology profiles, and requiring very low rates to effectively control weeds.

Question 3

Chemistry, Mode of Action & Differences from Other Auxins

Rinskor^TM active is the first member of the completely new family of synthetic auxin chemistry, Arylpicolinates. True or False.

Answer 3

False. Rinskor is the second member of the completely new family of synthetic auxin chemistry, Arylpicolinates, discovered by and is proprietary to Corteva Agrisciences.

Question 4

Chemistry, Mode of Action & Differences from Other Auxins

According to the Herbicide Resistance Action Committee’s (HRAC) classification, Rinskor^TM active belongs to which mode of action group?

Answer 4

HRAC/WSSA Group 4 according to the unified herbicide classification. Herbicides in this group mimic naturally occurring hormones by binding with specific auxin receptors in the cell’s nucleus and interrupt regular growth of weeds.

Question 5

Chemistry, Mode of Action & Differences from Other Auxins

Synthetic auxins were the first highly effective, and selective organic herbicides. They have been used for over 60 years and are still being used extensively. True or False.

Answer 5

True. After decades of being commercially used, synthetic auxins are still playing an critical role in weed management across diverse type of crops. Rinskor^TM active represents the new generation of the group and possesses many key advantages over the traditional auxins.

Question 6

Chemistry, Mode of Action & Differences from Other Auxins

I heard Rinskor^TM active is an auxin. Does this mean it has the same spectrum, performance and symptoms to those observed in products like 2,4-D, MCPA or Triclopyr?

Answer 6

It does not. As an arylpicolinate herbicide, it shows differentiated spectrum, enhanced performance on hard to control weeds and unique symptoms on grasses and sedges.

Question 7

Chemistry, Mode of Action & Differences from Other Auxins

Rinskor^TM active is a member of the pyridine carboxylic acids herbicide chemical family under HRAC/WSSA Group 4. True or False.

Answer 7

False. Rinskor is a member of the arylpicolinates, a completely new class or family of synthetic auxin chemistry within the HRAC/WSSA Group 4 category.

Question 8

Chemistry, Mode of Action & Differences from Other Auxins

Describe the uniqueness of arylpicolinates chemistry that Rinskor^TM active belongs to.

Answer 8

Chemical molecular substitutions yielded a new compound with significantly increased herbicidal potency that paved the way for a completely new generation of lower-dose-rate, synthetic auxin herbicides.

Question 9

Chemistry, Mode of Action & Differences from Other Auxins

What are the differences in mode of action between Rinskor^TM active and other chemical families under HRAC/WSSA Group 4 herbicides?

Answer 9

The pattern and level of affinity of Rinskor to bind with specific receptors differentiates it from other synthetic auxin herbicides.

Question 10

Chemistry, Mode of Action & Differences from Other Auxins

As an auxin herbicide, I guess Rinskor^TM active would not control grass weeds such as Echinochloa (barnyardgrass) and Urochloas (also known as Brachiarias, broadleaf signalgrass). True or False.

Answer 10

False. Although the product belongs to the synthetic auxins or growth regulator chemical group (HRAC/WSSA Group 4), it is unique as it belongs to the arylpicolinate family of chemistry. Rinskor can offer differentiated activity against the mentioned grasses.

Question 11

Chemistry, Mode of Action & Differences from Other Auxins

Which of the following HRAC/WSSA Group 4 herbicides should I recommend to treat a rice field where sedges, broadleaf and grass weeds co-exist?

Answer 11

Rinskor is an excellent option for broad spectrum weed control in rice. Its unique characteristics make it different from regular auxin herbicides in the market. A key attribute of Rinskor is its broad spectrum including important grasses, sedges and broad leaves affecting the rice crop. Furthermore, Rinskor can serve as a resistance management tool and fits well into long-term sustainability of agriculture.

Question 12

Chemistry, Mode of Action & Differences from Other Auxins

What advantage does Rinskor^TM active’s mode of action offer to growers?

Answer 12

With Rinskor, farmers have an alternative auxinic herbicide mode of action to manage susceptible weed biotypes that are resistant to other herbicide modes of action, including acetolactate synthase (ALS) inhibitors, ACCase inhibitors, quinclorac and glyphosate resistance, among others.

Question 13

Chemistry, Mode of Action & Differences from Other Auxins

Why, if Rinskor^TM active belongs to the auxin chemical group, do we say that it can control grasses? I know auxins are mostly broadleaf weed specific.

Answer 13

As an arylpicolinate Rinskor is unique in the way it can control important grasses such as Echinochloa. The controlled broad spectrum makes Rinskor an effective weed management tool in rice and other crops.

Question 14

Chemistry, Mode of Action & Differences from Other Auxins

Due to its differentiating characteristics as compared with regular auxin herbicides in the market, Rinskor^TM active is an excellent option for broad spectrum weed control in rice and other registered crops. True or False.

Answer 14

True. Rinskor is an excellent option for broad spectrum weed control in rice, including important grasses, sedges and broad leaves affecting the crop.

Question 15

Technical Attributes and Benefits

The introduction of Rinskor^TM active will bring value and benefits to global rice growers only. Is that true?

Answer 15

No. The introduction of Rinskor will also provide a powerful tool for effective weed management in other crop systems, in addition to rice.

Question 16

Technical Attributes and Benefits

Does Rinskor^TM active have a technical fit to be used in all rice cropping systems and rice types?

Answer 16

Yes. These include transplanted rice, direct seeded rice, japonica and indica rice, and conventional and hybrid rice.

Question 17

Describe other cropping systems, in addition to rice, that Rinskor^TM active has a fit into.

Answer 17

Rinskor has already been granted registrations for aquatic weed control, and for pastures and land management markets. Besides, Corteva is seeking to widely register Rinskor for use in turf and ornamentals, orchards, corn and other row crops, among others.

Question 18

Technical Attributes and Benefits

Rinskor^TM active is mainly used for pre-emergent treatment. True or False.

Answer 18

False. Rinskor is mainly used as a post-emergent herbicide.

Question 19

Technical Attributes and Benefits

Why is Rinskor^TM active so special as a post-emergent herbicide?

Answer 19

Rinskor provides effective post-emergent control of a unique broad spectrum of economically important grasses, broadleaf and sedge weeds.

Question 20

Technical Attributes and Benefits

Briefly describe the unique role that Rinskor^TM active plays in modern weed management.

Answer 20

Rinskor offers a differentiated mode of action to be used for the control of weeds in rice, aquatic environments, and other cropping systems.

Question 21

Technical Attributes and Benefits

What can Rinskor^TM active do to battle against the increasing challenges related to herbicide resistance?

Answer 21

Rinskor is an alternative herbicide to manage weeds that have developed target-site resistance to the most commonly used modes of action in rice (i.e. ALS, ACCase, Quinclorac, Propanil, among others).

Question 22

Technical Attributes and Benefits

What does the low use rates of Rinskor^TM active mean to the global environment?

Answer 22

Rinskor is effective at very low use rates, reducing millions of kilograms of environmental loading worldwide.

Question 23

Technical Attributes and Benefits

Rinskor^TM active presents very low risks to farmers, applicators, consumers, and wildlife. True or False.

Answer 23

True. Due to its favorable environmental fate, toxicology, and ecotoxicology profile, Rinskor imposes very low risks to farmers, applicators, consumers, and wildlife.

Question 24

Technical Attributes and Benefits

Consistent performance is one of the outstanding attributes that Rinskor^TM active possesses. True or False.

Answer 24

True. Rinskor provide consistent weed control across variable conditions and rice water management systems.

Question 25

Technical Attributes and Benefits

Define the selectivity of Rinskor^TM active to rice.

Answer 25

Rinskor has good selectivity to rice when applied under the recommended rates and use patterns.

Under certain circumstances, some crop response may be present, but the crop will recover and yield will not be compromised.

Question 26

Technical Attributes and Benefits

Describe the mobility of Rinskor^TM active.

Answer 26

1. Rinskor is a systemic post-emergence herbicide mainly absorbed by plant foliage.
2. It is metabolized to the active form and translocated symplastically through the vascular system.
3. It accumulates in the plant’s growing points or meristematic tissue where it exerts its herbicidal action.

Question 27

Technical Attributes and Benefits

It will take days or weeks for Rinskor^TM active to get into the plant’s cells. True or False.

Answer 27

False. Rinskor is rapidly absorbed into the plant’s cells where the herbicide mimics naturally occurring hormones by binding with specific auxin receptors in the cell’s nucleus. Rate and speed of absorption would depend on environmental conditions and weed species.

Question 28

Technical Attributes and Benefits

How long it will take for Rinskor^TM active to initiate its herbicidal action?

Answer 28

Within hours after application uncontrolled growth in treated weeds is initiated, disrupting multiple plant processes causing a loss of normal growth function.

Question 29

Technical Attributes and Benefits

When can I expect to see the initial herbicidal symptoms following a Rinskor^TM active application?

Answer 29

Within hours to days, visual symptoms appear and continue to develop leading to death in susceptible species usually within a few days or weeks after application.

Question 30

Technical Attributes and Benefits

Through which approach does Rinskor^TM active kill grass and sedge weeds?

Answer 30

Rinskor causes abnormal growth at the crown of grasses and sedges which results in disruption of the vascular tissue and ultimately in plant death. Technically, Rinskor triggers the degradation of repressor protein that controls the auxin-regulated gene, and the absence of repressor protein causes abnormal auxin production.

Question 31

Technical Attributes and Benefits

How do I know if Rinskor^TM active is acting in the treated grasses or sedges?

Answer 31

Susceptible grasses and sedges display swelling of the crown tissue followed by necrosis and death.

Question 32

Technical Attributes and Benefits

Broadleaf weeds treated with Rinskor^TM active display swelling of the crown tissue followed by necrosis and death. True or False.

Answer 32

False. Treated broadleaves display irregular leaf and stem growth similar to that caused by other synthetic auxins.

Question 33

Technical Attributes and Benefits

Rinskor^TM is highly compatible with many commonly used herbicides in today’s market. True or False.

Answer 33

True. In addition to products that contain Rinskor alone, there will be unique formulations powered by Rinskor, which have been optimized to contain other Corteva herbicides to help enhance the efficacy, weed spectrum and sustainability of the product line. Besides, Rinskor can be tank mixed with many of the herbicides currently used in rice and other crops to enhance spectrum of control.

Question 34

Technical Attributes and Benefits

Does Rinskor^TM active persist in the environment?

Answer 34

No. Rinskor rapidly degrades in soil, water and plant tissue.

Question 35

Technical Attributes and Benefits

Once Rinskor^TM active is applied, it quickly dissipates and degrades in soil and water into metabolites that have no biological activity at the levels detected in the environment. True or False.

Answer 35

True. Rinskor is a herbicide that is applied at low use rates, and the persistence of the product is short in soil and water. Once the product is applied, it quickly dissipates and degrades in soil and water into metabolites that have no biological activity at the levels detected in the environment.

Question 36

Technical Attributes and Benefits

Rinskor^TM active needs to be very carefully managed as it has very strict use precautions involving impact on animals, such as fish, bees and birds. True or False.

Answer 36

False. All pesticides should be handled with care. However, Rinskor is practically nontoxic to terrestrial and aquatic animals at the recommended use rates. Rinskor shows toxicity only on susceptible plants.

Question 37

Technical Attributes and Benefits

Describe the benefits of rapid degradation of Rinskor^TM active following application.

Answer 37

This is expected to result in fewer restrictions due to a favorable environmental and toxicological profile. In turn, growers will have the freedom to effectively manage crops and make cultivation decisions while preserving the environment and keeping fields productive for longer periods of time.

Question 38

Awards and Registrations

Why was Rinskor^TM active designated by the USA EPA as a Reduced Risk Pesticide for uses on rice and aquatics?

Answer 38

The designation is granted based on Rinskor’s favorable environmental fate, toxicology, and ecotoxicology profile.

Question 39

Awards and Registrations

Why did Rinskor^TM active receive the prestigious 2018 Green Chemistry Challenge Award?

Answer 39

Because Rinskor possesses favorable environmental/toxicology attributes while being used as an effective weed management tool for sustainable agriculture.

Question 40

Awards and Registrations

Is Rinskor^TM active the winner of any other awards besides the 2018 Green Chemistry Challenge Award?

Answer 40

Yes. Rinskor is the winner of several other awards including the “Agrow Award for Best New Crop Protection Product or Trait” and the “R&D 100 Award for Corporate Social Responsibility”.

Question 41

Awards and Registrations

Rinskor^TM active has a good fit to long-term sustainability. True or False.

Answer 41

True. With its outstanding performance in weed management, low use rates and a favorable environmental fate, toxicology, and ecotoxicology profile, Rinskor aligns well with Corteva Agriscience’s public commitment to advance sustainability for farmers, for the land, in our communities and in industry operations.

Question 42

Awards and Registrations

How does Rinskor^TM active help enable farmers to transition to direct-seeded rice cropping, reduce the number of applications and exposure risk, and reduce the risk of weed resistance?

Answer 42

Rinskor provides a reliable, sustainable solution which delivers effective control over a broad spectrum of important weeds for farmers around the world to improve their farming practices, crop yield and livelihoods.

Question 43

Awards and Registrations

Rinskor^TM active supports habitat restoration and human activities around areas impacted by invasive weeds. True or False.

Answer 43

True. The favorable environmental properties and low use rates of Rinskor translate to an extremely low environmental loading and impact, and higher crop production on existing land also helps mitigate need for expansion.

Question 44

Awards and Registrations

How does the use of Rinskor^TM active benefit communities?

Answer 44

It provides excellent broad-spectrum (grass, broadleaf, and sedges) weed control in rice and aquatic environment at very low rates. By controlling invasive weeds in water sources and aquatic environments, Rinskor help address problems with disruption of drinking or irrigation water supplies, loss of efficient navigation, degraded fish and wildlife habitat and loss of diversity and risk to threatened and endangered species.

Question 45

Awards and Registrations

In how many countries has Rinskor^TM active been registered?

Answer 45

Rinskor and its product line, either straight or in pre-mix formulations, have been registered and commercialized in more than 30 countries, including major geographies like EU, USA, China, Vietnam, Indonesia, Brazil, Colombia, Australia, Indonesia, Korea and Japan.

Question 46

Awards and Registrations

Are more registrations expected for Rinskor^TM active?

Answer 46

Certainly. Corteva Agriscience is working towards registering Rinskor for use in all major rice producing countries, plus obtaining registrations in many other countries where utility in additional crops is anticipated.

Question 47

Awards and Registrations

In September 2019, why did the USA EPA conclude that there is a reasonable certainty of no harm from aggregate exposure to Rinskor^TM active residues?

Answer 47

EPA performs a number of analyses to determine the risks from aggregate exposure to pesticide residues.

First, EPA determines the toxicity of pesticides.

Second, EPA examines exposure to the pesticide through food, drinking water, and through other exposures that occur as a result of pesticide use in residential settings.

Based on the information and the supporting documentation, EPA concluded that there is a reasonable certainty of no harm from aggregate exposure to Rinskor residues.

Question 48

What is the result of the USA EPA conclusion that there is a reasonable certainty of no harm from aggregate exposure to Rinskor^TM active residues?

Answer 48

EPA granted full tolerance exemption to Rinskor, eliminating the need to establish a maximum permissible level for residues.

Question 49

Awards and Registrations

Will the full tolerance exemption, granted to Rinskor^TM active by the USA EPA, automatically apply to other counties?

Answer 49

No. It doesn’t apply to other countries. Nevertheless Corteva has submitted tolerance (MRL) exemption petitions in other countries like Korea or Canada, and has submitted under the proposed exemption for compounds of low public health concern of CODEX-JMPR.