Hereditary and Chronic GN Flashcards
(15 cards)
What other disturbances are associated with Alport syndrome than GN?
Nerve deafness, Visual disturbances, nephritis
What is the most common inheritance pattern of Alport syndrome?
X-linked recessive (most cases)
What does microscopy of Alport syndrome look like?
Glomeruli with segmental proliferation or sclerosis, mesangial matrix increase
Foam cells
Persistence of fetal glomeruli
What does EM of Alport syndrome look like?
Lamina densa splitting
NOT FOCAL
What is the gene defect in Alport syndrome?
Type IV collagen
What is the course of alport syndrome?
Renal failure in 20-50 years
What is the inheritance pattern of thin membrane disease (Benign Familial Hematuria)
Autosomal
What is the course outcome of thin membrane disease?
Excellent if Heterozygous
Homozygous may progress to renal failure
What is the defective gene in Thin membrane disease?
Type IV collagen
What of the GN diseases discussed can present to Chronic GN? (in order)
- RPGN
- Focal GS
- Membranous AND MPGN
- IgA nephropathy
- PSGN
What immune complexes are seen in SLE Nephropathy?
ALL OF THEM.
What are the stages of Lupus Nephritis?
I: Normal
II: Mesangial involvement
III: Focal proliferative (Some proteinuria and hematuria)
IV: Diffuse proliferative (Hematuria and severe proteinuria)
V: Membranous GN (Severe proteinuria)
What are some microscopic findings in diabetic nephropathy?
Basement membrane thickening
Mesangial sclerosis
Nodular glomerulosclerosis
What is nodular glomerulosclerosis associated with?
Kimmelstiel wilson nodules (hyaline masses in periphery of glom)
What is the clinical course of diabetic nephropathy?
Microalbuminuria HTN Diabetic nephropathy ESRD Dialysis/Kidney/Pancreas transplant
