hereditary renal diseases, HTN, RTAs Flashcards Preview

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Flashcards in hereditary renal diseases, HTN, RTAs Deck (10):
1

Distal RTA: associations, presentation, tx

distal renal tubular cells can't excrete acid
usually inherited, may be seen with amphotericin
-pts present with vomiting, growth failure, acidosis, nephrocalcinosis
small doses alkali

2

type II RTA

imapred bicarb by the proximal renal tubules
-may be caused by gentamicin, or seen in fanconi syndrome
-causes vomiting, growth failure, acidosis, and muscle weakness

3

fanconi syndrome

proximal RTA, hyperphosphaturia, aminoaciduria, glucosuria, K wasting

4

type IV RTA

transient acidosis in infants and kids
-hyperkalemia is the hallmark
-may be seen in aldo deficiant states
-looks like potassium sparing diuretic, so treat with furosemide

5

Type of acidosis seen in RTA

hyperchloremic metabolic acidosis with normal anion gap

6

evaluation of RTA

-consider when pts present with hyperchloremic metabolic acidosis with normal anion gap
-serum K and phosphorus, urine pH, UA
-urine anion gap- positive urine anion gap seen in distal RTA (it is ammonia)

7

alport syndrome: definition, inheritance

progressive hereditary nephritis secondary to defects in side chains of type IV collagen
usually X-linked dominant

8

clinical features of alport syndrome

-HTN, hematuria, ESRD esp. in males
-hearing loss
-ocular abnormalities of the lens and retina

9

autosomal recessive polycystic kidney disease

-oligohydramnios, and possibly pulmonary hypoplasia
-enlarged kidneys
-severe HTN
-variable liver involvement

10

autosomal dominant polycystic kidney disease

variable findings
check for cerebral aneurysms
may also have flank pain/mass, HTN, UTI