High + Low E drugs

Question 1

low E: increase in Q

Answer 1

doesn’t do much bc PPB limited

slight decrease in E

Question 2

low E: increase in Clint

Answer 2

increase Cl == increase in E

t1/2 decreases + AUC decreases bc CL

Question 3

low E: increase in fu

Answer 3

less PPB: increase Cl + V, increase E

• no change in t1/2 bc Cl and V cancel out

— decrease in AUC bc increase in Cl

peak C decreases bc increase in V

Question 4

high E: increase in Q

Answer 4

increase in Q - increase in Cl + increase in F

t1/2 decrease

peak C increase bc F increases

no change in AUC bc change in Cl and F

Question 5

high E: increase in Clint

Answer 5

increase Clint: no change in Cl

• decrease in F (bc small increase in E)

AUC - decrease

decrease in F and AUC

Question 6

high E drug: increase in fu

Answer 6

decrease in PPB: decrease in F (no change on Cl)

AUC decrease + V increase

t1/2 increases bc V increases

C peak decreases bc change in V