high risk drug monitoring

Question 1

theophylline

Answer 1

before starting:
- U&Es (esp K+)
- liver function

• check plasma levels:
• 4 to 6 hrs after dose
• 5 days after starting treatment
• 3 days after dose adjustment

Question 2

antipsychotics

Answer 2

weight/BMI - weekly for the first 6 weeks, at 3 months, every 12 months

U&Es/eGFR - every 12 months

FBC - every at 12 months

blood lipids - at 3 months, every 12 months

plasma glucose/HbA1c - at 3 months, every 12 months

pulse/BP - after dose changes

ECG - after dose changes

prolactin - at 6 months, every 12 months

LFTs - every 12 months

Question 3

methotrexate

Answer 3

FBC liver and renal function tests every 1-2 weeks till stable then every 2-3 months

Question 4

digoxin

Question 5

statins

Answer 5

before initiation - creatine kinase, LFTs, renal function, hbA1c, TSH

LFTs at 3 months and at 12 months

patients at high risk of diabetes - hba1c measured every 3 months

Question 6

amiodarone

Answer 6

LFT before and every 6 months

TFT before and every 6 months

chest X-ray before
K+ before