High Yield Information for Exam 1 Flashcards by plasma opp

Oral Iron Dosage

200-400mg ferrous iron/day in a single dose

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Treatment for iron poising

Deferoxamine (iron-chelating compound)

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How is Deferoxamine given

Subcutaneous

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Dose for Oral B12 with pernicious anemia

1-2mg/day for 2 weeks then 1mg daily (~500X daily needed)

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If neurological symptoms are present in a pt that has megaloblastic anemia what is the dosage

1) 1000ug/day for 1 week
2) Weekly for 1 month
3) Monthly

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Adverse events with B12

None

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Treatment for Folate Def.

Oral Folate: 1mg/day for 4 months

*** Malabsorption present, dose 1-5mg/day

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High Doses of Folate can cause ___ and ___

Hypotension and Hypoglycemia

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What drug increases reticulocyte count <10 day

Epoetin Alfa

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Adverse events for Epoetin Alfa

1) Death
2) MI
3) Stroke
4) Venous thromboembolism
5) Tumor Progression

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How is Epoetin Alfa administrated

IV or Subcutaneously

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Indications of Epoetin Alfa

1) Chronic Kidney Disease
2) Cancer Chemotherapy
3) HIV Treatment

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What is used for sickle cell anemia treatment

1) Hydroxyurea

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MOA of Hydroxyurea

Boosts Fetal Hemoglobin

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What is the only disease modifying therapy approved for sickle cell disease

Hydroxyurea

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How is Hydroxyurea delivered

Orally

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What drug treats PNH

Eculizumab

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MOA of Eculizumab

Inhibits its cleavages to C5a and C5b

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How would you treat atypical hemolytic uremic syndrome

Eculizumab

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How does Eculizumab treat atypical hemolytic uremic syndrome

Inhibits complement mediated thrombotic microangiopathy

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Eculizumab is only available under

REMs (Risk evaluation and mitigation strategy)

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Eculizumab is administered via ___. Why?

1) IV

2) Antibody

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Dosage of Eculizumab

1) Once per week for 1st 4 wks

2) Maintenance dose given every two weeks

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Toxicities of Eculizumab

1) Viral Infections
2) Life-Threatening Meningococcal Infections
3) Headache

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What vaccine must you give to a pt 2 weeks before starting Eculizumab

Meningococcal Vaccine

What is the brand name for G-CSF

Filgrastim

Toxicities of Filgrastim

1) Allergic Rxn | 2) Bone Pain

How do you treat the bone pain associated with Filgrastim

NSAIDs

How long do you have to wait after chemotherapy to admin filgrastim

How is Filgrastim administrated

1) IV | 2) SC

Indications for Filgrastim

1) Nonmyeloid Malignancies recieving myelosuppressive anticancer drugs 2) Bone Marrow Transplant

Which drug that treats neutropenia can cause Edema

Sargramostim (GM-CSF)

Sargramostim will increase the production of

Neutrophils, Eosinophils, and Monocytes/Macrophages

How is Sargramostim delivered

IV or SC

Toxicities of Sargramostim

1) Edema and Fluid Retention 2) Dyspnea 3) Renal and Hepatic Dysfunction in pts already w/ those problems 4) Gasping Syndrome in premature infants

Why Sargramostim cause Gasping Baby Syndrome

Benzyl Alcohol

MOA of Plerixafor

1) Partial agonist of CXCR4 receptor

MOA of Oprelvekin (IL-11)

1) Unknown

Effects of Oprelvekin

Formation and Maturation of Megakaryocytes

Toxicities of Oprelvekin

1) Significant Edema 2) Cardiac Dysrhythmias 3) Blood Shot eyes 4) Severe Allergic Rxn

How is Romiplostim Administered

SC weekly

Effect of Romiplostim

Increase Platelet Count in Pts with ITP

MOA of Romiplostim

Bind TPO receptor

Indications of Romiplostim

1) ITP | - Used after failure of glucocorticoids and immune globins

Toxicity of Eltrombopag

Hepatotoxicity

MOA of Eltrombopag

Non-peptide TPO receptor agonist

How is Eltrombopag administered

Orally

Dose of Eltrombopag

Once a day

Indications of Eltrombopag

1) ITP | 2) Cirrhosis due to Hep C

Causes of Drug-induced thrombocytopenia

1) Myelosuppression | 2) Quinidine, Vancomycin, Heprin

How does Asprin decrease thromboxane A2

Cyclooxygenase-1

In Chronic Immune Thrombocytopenia there will be an increase of what cell type in the bone marrow?

Megakaryocyte

Antibodies are against what in Chronic Immune Thrombocytopenia

GPIIbIIIa

What are the two acquired forms of decreased platelet function disorders

1) Asprin Use | 2) Uremia

Inheritance of Kostmann Syndrome

Autosomal Recessive

Clinical Features of Kostmann Syndrome

Early Life Threatening Pyogenic Infection

How is Kostmann Syndrome associated with cancer

AML risk

What is known as a severe congenital neutropenia

Kostmann Syndrome

Cyclic Neutropenia has an ANC < ___ every __ - __ days

1) 200 2) 15 3) 35

Clinical Presentation of Cyclin Neutropenia

Cyclic Fever with Oral Ulcers

Inheritance of Cyclic Neutropenia

1) Autosomal Dominant or Sporadic

Risk for malignancy in Cyclic Neutropenia

None

Triad seen in schwann-diamond syndrome

1) Neutropenia 2) Exocrine pancreas insufficency 3) Skeletal abnormalities

Inheritance of Schwann-Diamond Syndrome

Autosomal Recessive

Risk for cancer in Schwann Diamond Syndrome

1) MDS or Leukemia

Malignancy association with Fanconi Anemia

1) AML 2) Brain Tumor 3) Wilms Tumor

When does Fanconi Anemia present

1) 1st 10 yrs of life

Clinical presentation of Fanconi Anemia in children

1) GU and Skeletal Abnormalities

Inheritance of Fanconi Anemia

Autosomal recessive

Malignancy association with Leukocyte Adhesion Def.

None

Clinical Presentation of Leukocyte Adhesion Def.

1) Delayed umbilical cord stump (>3wks) 2) Recurrent bacterial and fungal infections W/O PUS 3) Poor Wound Healing

Child has recurrent bacterial infections w/o pus. you sus. that the disease he has is ___ inheritance pattern.

1) Leukocyte Adhesion def. | 2) autosomal recessive

Another name for Hyper IgE Syndrome is

Job Syndrome

Triad of symptoms in Job syndrome

1) Severe Excezma 2) Recurrent Bacterial Infections (Staph) on skin 3) Pulmonary Infections

Job Syndrome is what type of inheritance

Autosomal Dominant

Malignancy association with Job Syndrome

Increaased Hodgkin Lymphoma

Triad of symptoms in Wiscott-Aldrich Syndrome

1) Recurrent Sinopulmonary and Ear Infections 2) Severe Atopic Dermatitis 3) Bleeding

Wiscott-Aldrich is associated with what type of cancer

Non-Hodgkin Lymphoma | -ESP. B Cell

Vaccinations after Splenomegaly

1) Streptococcus Pneumoniae 2) Neisseria Meningitidis 3) Herophilus Influenzae B

What is Kehr Sign. Describe position

1) LUQ pain due to phrenic nerve irritation - Splenic rupture below diaphragm 2) Elicited in recombinant position (laying down) with legs raised

Where is Castell's Point

1) Inferior interspace along left anterior axially line

High Yield Information for Exam 1 Flashcards

(81 cards)