HIST (Hagen): Hematopoiesis Flashcards
(51 cards)
Do cytokines and interleukins travel in blood? and what are they?
yup.
immune response cell signals
do RBCs and platelets stay in bloodstream?
yup!
do WBCs stay in blood?
they are suspended in blood, but they exit the bloodstream to enter lymph to put in work
What is serum?
(Serum) = ( plasma - clotting factors)
are most lab tests w/ plasma or serum?
serum!
What do we do we patient is bleeding due to lack of clotting factors?
transfer frozen plasma
When and where do you first see RBCs?
At two weeks (MESOBLASTIC PHASE)
In the yolk sac
When do you first see blood develop in liver?
At six weeks (HEPATIC PHASE).
When do you first see WBC develop?
At eight weeks (we didn’t really have a specific phase to it, for the record)
When do you begin to see blood in the spleen, liver, and bone marrow?
In the second trimester (splenic phase)
When do you see the myeloid phase?
end of second trimester
From birth two 20 yrs, a lot of blood cells are made in bone marrow, but what happens after age 20?
bone marrow gets replaced by fat.
and by age 20, only sternum and hips are sites of bone marrow
When can you reactivate splenic hematopoesis in adults
under severe blood loss
Where is blood first made?
long bone marrow
where do myeloid cells from bone marrow mature?
they mature once they enter bloodstream
where do B lymphocytes mature?
in the gut or in lymphocytes
where do T cells mature?
in the thymus
What’s sinusoidal circulation
blood circulation in bone marrow
Advantageal reticular cells? (not to confuse with reticulocye)
provide good framework for bone marrow cells to develop
How would we identify mekaryocytes on bone marrow pics?
They’re multinucleated, but you cant see that on the slide. they kinda look like big lymphocytes on the bone marrow preps
How do apdipocytes look like?
like big white circles without a nucleue
How often to pluripotent cells divide and what do they divide into?
Not often!
they divide into OTHER STEM CELLS. namely multipotent stem cells
Why are lymphoid cells and myeloid cells said to be from the same line?
They come from the same mutipotent stem cell line.
CFU-gemm vs CFU-ly
What are multipotent stem cells?
cells that the pluripotent stem cells differentiated to! They divide into more limited number of lineages, for example cfu-gemm divides into five types of cfu progenitors of the myeloid line. similarly, cfu-ly differentiates into cfu lymphoid B and T lineages.
