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Pharma > Histamine, Serotonin and Ergot Derivatives > Flashcards

Histamine, Serotonin and Ergot Derivatives Flashcards

1
Q

Excess Histamine Detected through

A

Imidazole Acetic Acid in the Urine

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2
Q

Smooth Muscle

Inc IP3 DAG

A

H1

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3
Q

Stomach, Heart, Mast Cells

Inc cAMP

A

H2

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4
Q

Nerves, Brain

Dec cAMP

A

H3

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5
Q

Leukocytes

Dec cAMP

A

H4

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6
Q

Pain and Itching

Broncoconstriction, Vasodilation, Local Edema

A

H1

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7
Q

Gastric Acid Secretion, Cardiac stimulation

A

H2

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8
Q

Modulation of NTs

A

H3

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9
Q

Leukocyte chemotaxis

A

H4

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10
Q

Blocks Peripheral CNS H1 plus a and M receptor block

Anti motion sickness

A

1st Gen H1 - Diphenydramine

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11
Q

H1 block

No autonomic or anti motion sickness effects

A

2nd Gen H1 - Cetirizine

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12
Q

H1 Anti emetic

A

Promethazine -H1 1st gen

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13
Q

Serotonin Syndrome

A

Cyproheptadine - H1 1st gen

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14
Q

Has Alpha 1 blocking and local anesthetic affect

A

1st Gen H1

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15
Q

Fatal arrhythmias from interaction with Azoles/Erythromycin

A

Terfenadine/ Astemizole

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16
Q

H2 Antihistamine

A 
Ranjit's Family has NIZe Chimney
Ranitidine
Famotidine
Nizatidine
Cimetidine
17
Q

PUD
Zollinger Ellison
GERD

A

H2 Antagonist

18
Q

SE: Cimetidine

A

Gynecomastia

Decreased Hepatic flow

19
Q

Serotonin from AA

A

Tryptophan

20
Q

Serotonin metabolized by

A

MAO

21
Q

Excess Serotonin in urine

A

5 HIAA

Pharma (20 decks)

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