Histiocytic sarcomas Flashcards
1
Q
Histiocytic sarcoma behavior
A
- ROUND CELL TUMORS (or very high grade sarcomas)
2
Q
How will histiocytic sarcomas often report?
A
- Round cell sarcoma, histiocytic tumor possible
3
Q
Cell origin for histiocytic sarcomas
A
- Macrophage origin
- Macrophages or antigen presenting cells
4
Q
Signalment for histiocytic sarcomas
A
- Flat coated retrievers are the poster child
- Golden Retrievers
- Rottweilers
- Any age, sex, or breed
5
Q
Presentation for histiocytic sarcomas
A
- masses often associated with muscle groups or joints but can be anywhere
- Often painful
- Often require HIC for correct diagnosis
6
Q
Staging for histiocytic sarcoma
A
- Draining lymph node, though sometimes the tumor appears to arise in a lymph node
- Lungs (like a round cell)
- Abdomen - liver and spleen
7
Q
Treatment for histiocytic sarcoma - when to do?
A
- HAS to be localized to one site (stage 1)
8
Q
Treatment for histiocytic sarcoma
A
- Surgery (if you can remove with minimal morbidity)
- Radiation therapy (palliative protocol)
- Chemotherapy with lomustine
9
Q
Prognosis for histiocytic sarcoma
A
- Rarely curable, but will initially respond to treatment
10
Q
Median survival for histiocytic sarcoma
A
- 9 months with radiation and lomustine
- Long term survival (+/-) cure when low stage
11
Q
What is a histiocytoma?
A
- Langerhans cell proliferation
12
Q
How do histiocytomas present?
A
- Dermal nodules in a young dog, often on the extremities
13
Q
Histiocytoma prognosis and treatment
A
- Very good
- Spontaneously regress or removal curative
14
Q
Hemophagocytic histiocytic sarcoma or malignant histiocytosis - what is the cell type that causes?
A
- Phagocytic macrophages
15
Q
WHo gets hemophagocytic histiocytic sarcoma?
A
- Most common in Bernese mountain dogs
- Can occur in other breeds
