Histo 300 To 522 Trusted Flashcards
(66 cards)
(“What is the title of Dr. Mustapha A. Ajani’s section on page 300?”
“HAEMOGLOBINOPATHIES”)
(“What is the molecular composition of haemoglobin?”
“A tetramer of two globin chains linked with heme.”)
(“What are the major globin chains in adults?”
“Paired α (141 amino acids) and paired β (146 amino acids) chains.”)
(“What is the state of the iron molecule in heme?”
“Fe2+ in the ferrous state.”)
(“How many haemoglobin molecules does each heme molecule bind?”
“A single haemoglobin molecule.”)
(“What is the nature of the haemoglobin molecule and individual globin chains?”
“The haemoglobin molecule is soluble but individual globin chains are insoluble.”)
(“What are haemoglobinopathies?”
“Disorders affecting the structure
(“How are haemoglobinopathies inherited?”
“As autosomal co-dominant genes.”)
(“What are some presentations of haemoglobinopathies?”
“Haemolytic anemias
(“What are locally advanced disease and inflammatory carcinoma examples of?”
“Minor prognostic factors.”)
(“What are some histologic subtypes mentioned on page 305?”
“Tumor grade (SBR)
(“What does HER2/neu or c-erb B2 relate to?”
“Minor prognostic factors.”)
(“What is Lymphovascular invasion (LVI) a factor for?”
“Minor prognostic factors.”)
(“What does proliferative rate (PCNA
Ki 67) measure?”
(“What does DNA content relate to in histology?”
“Minor prognostic factors.”)
(“What does NM 23 relate to in histology?”
“Minor prognostic factors.”)
(“What is the focus of the text on page 310?”
“Introduction to Haemoglobinopathies.”)
(“What are the types of haemoglobin molecules mentioned?”
“HbA
(“What is the composition of HbA?”
“Two alpha and two beta chains.”)
(“What is the composition of HbA2?”
“Two alpha and two delta chains.”)
(“What is the composition of HbF?”
“Two alpha and two gamma chains.”)
(“What is the primary haemoglobin in fetal life?”
“HbF.”)
(“What is the primary haemoglobin in adults?”
“HbA.”)
(“What genetic mutation causes Sickle Cell Disease (SCD)?”
“A mutation in the beta-globin gene.”)
