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High Yield Path - Histo > Histo: Upper GI Disease > Flashcards

Histo: Upper GI Disease Flashcards

(44 cards)

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1
Q

What is a key histological feature of the oesophageal mucosa?

A

Presence of submucosal glands

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2
Q

what is the Z-line?

A

The point in the oesophagus at which the epithelium transitions from being squamous to being columnar

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3
Q

What does the body and fundus of the stomach have in abundance?

A

Specialised glands responsible for producing acid and enzymes

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4
Q

Which part of the stomach tends to be affected by H. pylori-associated gastritis?

A

Pylorus and antrum

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5
Q

What are the three layers of the gastric mucosa?

A
  • Columnar epithelium
  • Lamina propria
  • Muscularis mucosa
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6
Q

What is the normal villous: crypt ratio?

A

2:1

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7
Q

What does the presence of goblet cells in the stomach signify?

A

Intestinal metaplasia

NOTE: goblet cells are NOT normally seen in the stomach

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8
Q

What is the characteristic histological feature of acute oesophagitis?

A

Presence of lots of neutrophils

This is usually caused by GORD

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9
Q

What can acute oesophagitis result in?

A
  • Ulceration
  • Haemorrhage
  • Perforate
  • Fibrosis
  • Stricture
  • Barrett’s oesophagus
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10
Q

Define Barrett’s oesophagus.

A

Metaplastic process by which the normal sqaumous epithelium of the lower oesophagus is replaced by columnar epithlieum

NOTE: this is also known as columnar-lined epithelium (CLO)

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11
Q

What further degree of metaplasia is associated with an even greater risk of cancer than Barrett’s oesophagus?

A

Intestinal metaplasia - goblet cells become visible

NOTE: metaplasia is reversible

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12
Q

Outline the histological stages that occur leading up to Upper GI cancer

A
  1. Metaplasia (not considered pre-malignant as is reversible)
  2. Dysplasia (histological and cytological changes similiar to that of cancer but no invasion of basement membrane)
  3. Adenocarcinoma (invasion through basement membrane occurs)

The Upper GI pathway to cancer differs from the lower GI. Upper GI is referenced as flat pathway (metaplasia –> dysplasia –> cancer). While Lower GI is referred to as Polyp pathway as often there is formation of a polyp.

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13
Q

Define dysplasia.

A

Changes showing some of the cytological and histological features of malignancy but with no invasion through the basement membrane.

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14
Q

What is squamous carcinoma of the oesophagus associated with?

A
  • Smoking and alcohol
  • It tends to affect the upper/middle 2/3rds of the oesophagus
  • It is the most common type of oesophageal cancer in Africa
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15
Q

What are the main histological features of squamous cell carcinoma of the oesophagus?

A

Cells produce keratin (normal oesophageal squamous epithelium is non-keratinised)

Intercellular bridges

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16
Q

What is adenocarcinoma of the oesophagus associated with

A
  • Bottom 1/3rd
  • Associations: GORD, Barrett’s oesophagus
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17
Q

What are the main histological features of adenocarcinoma of the oesophagus?

A

Histology:
- Glandular epithelium
- Mucin

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18
Q

How is eosinophilic oesophagitis treated?

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A
  • Steroids
  • Allergen removal

NOTE: this is associated with an allergic reaction (asthma of the oesophagus). It is due to allergy to food causing muscle spasm and dysphagia.

19
Q

What is the commonest cause of oesophageal varices?

Study These Flashcards
A
  1. Cirrhosis of the liver (Most common)
  2. Portal vein thrombosis
20
Q

Histological differences between Acute and Chronic Gastritis

Study These Flashcards
A

Acute Gastritis = Neutrophil infiltration

Chronic Gastritis = Lymphocyte infiltration (may have some neutrophils due to co-existent acute changes)

21
Q

Causes of Acute Gastritis

Study These Flashcards
A

Chemical = Aspirin/NSAIDs, Alcohol, Corrosives
Bacterial = H. pylori, CMV

22
Q

Causes of chronic gastritis

Study These Flashcards
A

ABCD:
Autoimmune (atrophic) = i.e. antiparietal ABs
Bacteria (atrophic/non-atrophic) = H.pylori, CMV
Chemical = NSAIDs, bile reflux
D = IBD

23
Q

What is mucosa-associated lymphoid tissue (MALT) and what is their presence indicative of?

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A
  • Chronic gastritis caused by H. pylori infection induces lymphoid tissue in the stomach
  • The presence of lymphoid follicles in a stomach biopsy, is highly suggestive of H. pylori infection
  • This is important because it is associated with an increased risk of lymphoma (MALToma)
24
Q

Name a key virulence factor that enables H. pylori to cause chronic infection.

Study These Flashcards
A

Cag-A positive H. pylori has a needle-like appendage that injects toxins into intercellular junctions allowing bacteria to attach more easily

25
Outline the differing outcomes of H.Pylori infection
* Non-atrophic pan-gastritis --> MALToma (due to likely chronic infection) * Atrophic Body-predominant gastritis --> Ulcer, Adenocarcinoma * Antrum-predominant --> duodenal ulcer *memorise: atrophic = adenocarcinoma (A = A) while non-atrophic = MALToma *
26
Two Pathways that lead to development of GI cancer
- Metaplasia-Dysplasia pathway (upper GI) - Adenoma-Carcinoma pathway (lower GI)
27
Define gastric ulcer.
Erosion where the depth of the loss of tissue goes beyond the muscularis mucosa (into the submucosa) NOTE: if you only get loss of surface epithelium not past the lamina propria then it is just an erosion
28
What is the difference between acute and chronic ulceration?
Chronic ulcers are accompanied by scarring and fibrosis
29
What must you do with all gastric ulcers?
They should all be biopsied to rule out malignancy.
30
List some complications of gastric ulcers.
Bleeding (anaemia, shock) Perforation (peritonitis)
31
What changes can be seen in the stomach prior to gastic cancer
Gastric Intestinal Metaplasia = presence of goblet cells in the mucosa of the stomach. * Occurs in response to long term damage. NOT Pre-malignant but can ldead to dysplasia (which is pre-malignant) * associated with increased risk of cancer Gastric Epithelial Dysplasia = abnormal epithelial pattern of growth * some cytological / histological features of malignancy but no invasion through the basement membrane
32
Risk factors for gastric cancer
- Host genetic factors - Environmental factors - Bacterial virulence factors (Cag-A) - Gastric phenotypes
33
What type of cancer is gastric cancer?
* 95% adenocarcinoma * 5% squamous cell carcinoma, lymphoma (MALToma), gastrointestinal stromal tumour (GIST), neuroendocrine tumours
34
What are the two main morphological subtypes of gastric adenocarcinoma? What are their key features?
* Intestinal: well-differentiated, presence of big gland containing mucin * Diffus: poorly differentiated, composed of single cells with no attempt at gland formation
35
Name two types of diffuse adenocarcinoma of the stomach.
* Linitis plastica * Signet ring cell carcinoma
36
What is the overall survival rate of gastric cancer?
15%
37
What is gastric lymphoma?
* Lymphoma of the gastric mucosa that is driven by chronic inflammation (*H. pylori gastritis*) * Consists of lots of B lymphocytes (marginal zone) * MALToma is a type of B cell Non-Hodgkin's Lymphoma NOTE: if *H. pylori* is also present, crypts may also contain neutrophils
38
What causes duodenitis and duodenal ulcers?
* Caused by increased acid produced in the stomach that spills into the duodenum * It can also occur due to chronic inflammation and gastic metaplasia with *H. pylori* infection
39
List some other pathogens that affect the duodenum.
* CMV * Cryptosporidium * Giardiasis * Whipple's disease (*Tropheryma whippelii*) These are usually seen in immunosuppressed patients. Note that H. Pylori is behind almost 100% of duodenal ulcers
40
List some histological features of coeliac disease (that lead to malabsorption)
* Villous atrophy * Crypt hyperplasia * Increased intraepithelial lymphocytes (\>20 per 100 enterocytes) NOTE: the T cell response to gliadin in Coeliac disease is responsible for the damage to villi
41
What is lymphocytic duodenitis?
* When you get the inflammatory changes of coeliac disease (increased intraepithelial lymphocytes) but without architectural changes (loss of villi and crypt hyperplasia) * Many people with this condition either have coeliac disease or will go on to develop coeliac disease
42
How is coeliac disease diagnosed?
Antibodies: anti-tTG, anti-endomysial Duodenal biopsy (villous atrophy) NOTE: duodenal biopsy will be normal in people with coeliac disease who have been following a strict gluten-free diet
43
Which other condition has very similar clinical and histological features to coeliac disease?
Tropical sprue
44
What type of lymphoma is duodenal lymphoma?
T cell lymphoma NOTE: lymphomas in the stomach due to *H. pylori* are B cell lymphomas

High Yield Path - Histo (6 decks)

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