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LECOM PBL spring 2017 > histology chapter 14- lymphatics > Flashcards

histology chapter 14- lymphatics Flashcards

(77 cards)

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1
Q

what is a substance that can induce a specific immune response

A

antigen

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2
Q

what are the 3 major types of lymphocytes

A

NK cells, B cells, T cells

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3
Q

where are langerhans cells found

A

only in the middle layer of the epidermis

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4
Q

what forms the structural meshwork within the tissue of the thymus

A

epithelioreticular cells

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5
Q

what cells account for the majority of circulating lymphocytes

A

T cells

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6
Q

what markers are expressed by ALL mature T cells

A

CD2, CD3, CD5, CD7

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7
Q

what cytokines do Th1 cells synthesize

A

IL-2, IFN-gamma, TNF-alpha

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8
Q

what cytokines do TH2 cells synthesize

A

IL-4, IL-5, IL-13

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9
Q

what are the CD markers of B cells

A

CD9, CD20, CD19

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10
Q

what is the function of CD1

A

interaction with MHC1, developmental markers for T cells & langerhans cells of the skin

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11
Q

what is the function of CD2

A

adhesion molecules, used as clinical marker for T cells

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12
Q

what is the function of CD3

A

form complex with TCR

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13
Q

what is the function of CD4

A

interact with MHC2 , bind viral protein gp120 to HIV1 and HIV2

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14
Q

what is the role of CD5

A

costimulatory molecules that appear on mature T and B cells; high levels in chronic lymphocytic leukemia

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15
Q

what is the role of CD7

A

bind the PI-3 kinase, useful clinical marker for T-cell leukemia stem cells

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16
Q

what is the role of CD8

A

interact with MHC1

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17
Q

what is the role of CD9

A

facilitate aggregation of platelets, cell adhesion and cell migration

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18
Q

what is the role of CD10

A

zinc metalloprotease, common marker for acute lymphoblastic leukemia

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19
Q

what is the role of CD16a

A

clinical marker for NK cells, function as Fc receptor for aggregated IgG, mediate phagocytosis and ADCC cytotoxicity

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20
Q

what is the role of CD19

A

coreceptor with CD21, clinical marker for all stages of B cell development

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21
Q

what is the role of CD20

A

form Calcium channels; marker for late stage of B cell development

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22
Q

what is the role of CD21

A

receptors for C3d complment protein and for EBV

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23
Q

what is the role of CD22

A

B cell adhesion molecules; mediate B cell to T cell adhesion

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24
Q

what is the role of CD23

A

low affinity receptor for Fc portion of IgE that mediates IgE dependent cytotoxicity and phagocytosis by macrophages and eosinophils

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25
what is the role of CD24
expressed in late stage of B cell differentiation
26
what is the role of CD34
clinical marker for HSCs and ligand for CD62L. mediate attachment of stem cells to bone marrow ECM
27
what is the role of CD35
complement receptor 1; promote phagocytosis of complement-coated particles, bind C3b and C4b
28
what is the role of CD38
NAD glycohydrolase; used as markers for T cell activation and proliferation
29
what is the role of CD45
tyrosine phosphatase; leukocyte common antigen; required for T and B cell receptor signal transduction
30
what is the role of CD56
clinical marker for NK cells; isoforms of neural adhesion molecules
31
what is the role of CD94
clinical marker for NK cells
32
what does the Fc component do
effector functions
33
what is the initial response to an antigen
inflammation
34
what is another name for type 1 hypersensitivty
anaphylactic hypersensitivity
35
what are allergic reactions mediated by (immunoglobulin)
IgE
36
what immunoglobulin directs NK cells to their target for ADCC
IgG
37
what cells are CD4+CD25+FOXP3+
Treg cells
38
what are some of the cytokines that Treg cells secrete
IL-10, TGF-beta
39
what is the action of IL-1
stimulates inflammatory responses; induces fever; facilitates proliferation of CD4+ T cells and proliferation and differentiation of CD8+ cells
40
what is the action of IL-2
induces proliferation and differentiation of CD4+ T cells and to lesser degree CD8+, NK cells and B cells
41
what is the role of IL-3
induces proliferation of hematopoietic stem cells
42
what is the role of IL-4
induces proliferation and differentiation of B cells, CD4+ T cells; activates macrophages; promotes synthesis of IgE and IgG
43
what is the role of IL-5
induces proliferation and differentiation of eosinophils; stimulates B cells to secrete IgA
44
what is the role of IL-6
stimulate differentiation of hematopoietic cells; induces growth of activate B cells; APPs
45
what is the role of IL-7
stimulates growth and differentiation of progenitor B and T cells
46
what is the role of IL-9
facilitates growth of CD4+ T cells (but not CD8+); activates mast cells
47
what is the role of IL -10
acts on T cells as cytokine inhibitor; inhibits macrophage functions
48
what is the role of iL-11
facilitates growth of hematopoietic cells, mainly megakaryocytes
49
what is the role of Il-12
stimulates growth of NK cells, Thcells and CTLs
50
what is the role of IL-13
modulates B cell response and promotes IgE synthesis
51
what is the role of IL-14
induces production of memory B cells
52
what is the role of Il-16
activates migration of CD8+ T cells, monocytes and eosinophils
53
what is the role of IL-17
stimulates endothelial cells and fibroblasts to secrete cytokines
54
what kind of macrophages are activated by IFN-gamma
M1
55
what protein is highest in HIV envelope
gp120
56
what does gp120 bind to
CD4
57
what tissue composes the capsule of lymph nodes
dense connective tissue
58
what type of collagen to reticular cells synthesize and secrete
type 3 collagen
59
what are Dendritic cells derived from
bone marrow
60
what type of cells are mostly in the paracortex
T cells
61
what are the site of fluid absorption and entrance for circulating lymphocytes into the lymph nodes
HEVs
62
where is the thymus located
superior mediastinum
63
what do common lymphoid progenitor (CLP) cells develop into
immunocompetent T cells
64
where are type 1 epithelioreticular cells found
located at the boundary of the cortex and the connective tissue as well as between the cortical parenchyma and trabecular
65
where are type 2 epithelioreticular cells found and what do they express
located within the cortex and are stellate and express MH1 and MHC2 molecules
66
where are type 3 epithelioreticular cells found and what do they express
located at the boundary of the cortex and medulla; express MHC1 and MHC2
67
what are hassle's corpuscles derived from
type 6 epithelioreticular cells
68
where are type V epithelioreticular cells found
through medulla
69
what type of epithelioreticular cells are involved in the blood-thymus barrier
type 1
70
where are most blood-borne antigens addressed
spleen
71
what does the connective tissue of the capsule and trabeculae of the spleen contain
myofibroblasts
72
what do lymphocytes that aggregate around the central artery of the spleen constitute
PALS
73
what distinguishes the PALS from typically lymphatic nodules at other sites
presence of central artery
74
what does red pulp contain
splenic sinuses, penicillar arteries, sheathed capillaries, splenic cords
75
what part of the lymph nodes has lymph nodules
superficial cortex only
76
where do afferent lymphatic vessels pass through the lymph nodes
through the capsule
77
where do the efferent lymphatic vessels leave the lymph nodes
hilum

LECOM PBL spring 2017 (16 decks)

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