HISTOLOGY - WBC Disorder and Pulm

Question 1

Answer 1

ALL and AML

1. Scant basophilic cytoplasm
2. FINE Nuclear Chromatin w/Convolutions

(Note: Unable to differentiate ALL from AML with this Histology)

Question 2

Answer 2

Positive TdT Staining indicative of

ALL Specifically

Question 3

Answer 3

Erythroid Precursors in

MyeloDysplastic Syndrome (MDS)

[Nuclear BIMS - Budding / irregularities / multinucleation / separation of lobes]

Question 4

Answer 4

ProMyelocytes with AUER RODS –indicative of

aPL - Acute PROmyelocytic Leukemia

(type of AML)

Question 5

Answer 5

Positive [MyeloPerOxidase Stain] with Dark Brown consolidation indicating

AML

Question 6

Answer 6

Positive [AnBe Stain - Alpha napthyl Butyrate esterase] indicating

AML

(monocytic lineage)

Question 7

Answer 7

Smudge Cells

in [CLL-SLL]

Question 8

Answer 8

[small lymphocytes w/scant cytoplasm]

see in a lymph node of [CLL-SLL]

Question 9

Answer 9

Hairy Cell Leukemia

Question 10

Answer 10

Floret Cell

in

ATL - [Adult T-cell Leukemia/Lymphoma]

Question 11

Answer 11

[Benign Reactive Follicle]

in

Follicular Lymphoma

Question 12

Answer 12

Follicular Lymphoma

Abnormal Brown Stain in center of lymph node

Question 13

Answer 13

Follicular Lymphoma

Question 14

Answer 14

Mantle Cell Lymphoma

Cyclin D1 Overexpression

Question 15

Answer 15

Burkitt Lymphoma

Starry Sky Appearance

Question 16

Answer 16

DLBL [Diffuse Large B-cell Lymphoma]

Spleen with ​Fish Flush Appearance

Question 17

Answer 17

DLBL - [Diffuse Large B-cell Lymphoma]

Multiple Nucleoli (dark structures) with
[Vesicular Chromatin - bubbly appearance]

Question 18

Answer 18

PTCLn (Peripheral T-Cell Lymphoma - not otherwise specified)

Heterogenous Polymorphic appearance

Question 19

Answer 19

[Hodgkins Lymphoma: Nodular Sclerosis]

Lacunar Cells

Question 20

Answer 20

[RSO cell - Reed Sternberg OwlEye]

Hodgkins Lymphoma

Question 21

Answer 21

[RSO cell - Reed Sternberg OwlEye] -

Mononuclear variant

in Hodgkins Lymphoma

Question 22

Answer 22

[RSO cell - Reed Sternberg OwlEye] -

Lacunar variant

in Hodgkins Lymphoma

Question 23

Answer 23

Popcorn RSO Variant cells

in

Hodgkins Lymphoma: Lymphocyte Predominant

Question 24

Answer 24

[Dark Lytic Lesions] of the Skull

indicating

Multiple Myeloma

Question 25

Answer 25

**Mott Cell** in Bone Marrow Biopsy indicating **Multiple Myeloma**

Question 26

Answer 26

**CML - Chronic Myelogenous Leukemia** *Peripheral Blood Smear showing more WBC than usual*

Question 27

Answer 27

**CML - Chronic Myelogenous Leukemia** *Peripheral Blood Smear showing INC _Basophils_*

Question 28

Answer 28

**CML - Chronic Myelogenous Leukemia** *Bone Marrow showing [Abnormal 100% Cellularity-_mainly Granulocytes_] with no Fat Cells*

Question 29

Answer 29

*Tear Drop Cells* indicating [**CIPM- C**hronic **I**diopathic **P**rimary **M**yelofibrosis]

Question 30

Answer 30

**Essential Thrombocytosis**

Question 31

Answer 31

**Primary Bronchus**

Question 32

Answer 32

**TERTIARY BRONCHUS AND BRONCHIOLE**

Question 33

Answer 33

**Bronchogenic Cyst**

Question 34

Answer 34

Cyst of Varying Sizes in the Lung

Question 35

Answer 35

Pulmonary Sequestration

Question 36

Answer 36

Pink, Granular **Edema Fluid** within alveolar spaces

Question 37

Answer 37

**ARDS** (*as long as no cardiac failure is present*)

Question 38

Answer 38

*Early Exudative Phase* of **ARDS**

Question 39

Answer 39

ARDS – late proliferative and fibrosis stages.

Question 40

Answer 40

**Hyaline Membrane** **(***Fibrin + Necrotic Cells**)***

Question 41

Answer 41

Question 42

Answer 42

INC [submucosal glands/goblet cells] and [Reid Index \> 50%] in ## Footnote **Chronic Bronchitis**

Question 43

Answer 43

***Centriacinar* EmPhysema**

Question 44

Answer 44

***Panacinar*** **EmPhysema**

Question 45

Answer 45

***Irregular* EmPhysema**

Question 46

Answer 46

Cilia with *Missing Dynein Arms* in ## Footnote **Kartagener Syndrome**

Question 47

Answer 47

**Idiopathic Pulmonary Fibrosis**

Question 48

Answer 48

*Cobblestone Pleura* indicating **IPF (I**nterstitial **P**ulmonary **F**ibrosis)

Question 49

Answer 49

**Usual Interstitial PNA** (AKA [**I**nterstitial **P**ulmonary **F**ibrosis] and [Cryptogenic Fibrosing Alveolitis]

Question 50

Answer 50

**Anthracosis** *(from Coal Dust Pneumoconiosis)*

Question 51

Answer 51

**Progressive Fibrosis** ## Footnote * (from Coal Dust Pneumoconiosis)* * 3rd stage - Black Lung*

Question 52

Answer 52

Silica Crystals under polarized light indicating **Silicosis** *Type of Pneumoconiosis*

Question 53

Answer 53

**Asbestos Bodies** indicating *Asbestosis*

Question 54

Answer 54

**[Pleural Plaques w/calcification]** indicating *Asbestos*

Question 55

Answer 55

**Granulomas** in *Bronchial Epithelium*

Question 56

Answer 56

**Sarcoidosis**

Question 57

Answer 57

**Sarcoidosis**

Question 58

Answer 58

**Signet Ring** indicating *Bronchiectasis*

Question 59

Answer 59

**Rim of Fibrosis** (*around lower lobes of lung*) indicating **I**nterstitial **P**ulmonary **F**ibrosis / UIP

Question 60

Answer 60

**Meniscus** indicative of *Pleural Effusion*

Question 61

Answer 61

**[Layering while in Lateral Decubitus]** indicative of *Pleural Effusion*

Question 62

Answer 62

**Loculations** indicating *Pleural Effusion*

Answer 63

**Black Area + No Lung Markings** indicating *PTX (pneumothorax)*

Question 64

Answer 64

**PTX (pneumothorax)**

Question 65

Answer 65

**SQuamous Cell Carcinoma**

Question 66

Answer 66

**Intercellular Bridges** indicating *SQuamous Cell Carcinoma*

Question 67

Answer 67

**Keratinization** indicating *SQuamous Cell Carcinoma*

Question 68

Answer 68

Irregular **[****S****piculated Mass]** with entrapped anthracosis indicating *Adenocarcinoma*

Question 69

Answer 69

Question 70

Answer 70

*Well demarcated nodule* in **[AAH-A**typical **A**denomatous **H**yperplasia] (which progresses to Adenocarcinoma)

Question 71

Answer 71

**[AiS BAC]** ## Footnote *Adenocarcinoma in-Situ / BronchioloAlveolar Carcinoma*

Question 72

Answer 72

**Thyroid Tx Factor 1** indicating Adenocarcinoma

Question 73

Answer 73

**SubTypes of Adenocarcinoma** a. Acinar adenocarcinoma b. Papillary adenocarcinoma c. Solid adenocarcinoma d. Mucinous adenocarcinoma

Question 74

Answer 74

**[Large Cell Undifferentiated Carcinoma]** * No squamous or adeno differentiation by morphology* * OR by immunohistochemistry*

Question 75

Answer 75

*Azzopardi Effect-staining on vessel walls* indicating [**SOC- S**mall **O**at cell **C**arcinoma]

Question 76

Answer 76

[**SOC**- **S**mall **O**at cell **C**arcinoma]

Question 77

Answer 77

[Polypoidal endobronchial mass] + [no necrosis] indicating **Bronchical Carcinoid**

Question 78

Answer 78

Bland Cell Nest separated by vasculature indicating **Bronchial Carcinoma**

Question 79

Answer 79

**SQ**amous cell **C**arcinoma

Question 80

Answer 80

**AD**eno**C**arcinoma

Question 81

Answer 81

[**SOLC** - **S**mall **O**at cell **L**ung **C**arcinoma] (*blue*)

Question 82

Answer 82

**LCUC** - **L**arge **C**ell **U**ndifferentiated **C**arcinoma

Question 83

Answer 83

**Normal Mesothelial Cells** in Pleura cavity

Question 84

Answer 84

**Mesothelioma**

Question 85

Answer 85

**Mesothelioma** *on EM and Stain*

Question 86

Answer 86

**Metastatic signet ring ADenoCarcinoma**

Question 87

Answer 87

*Engorged Alveolar capillaries* in **Pulmonary Edema**

Question 88

Answer 88

**Pulmonary Embolus**

Question 89

Answer 89

**Pulmonary Embolus** being shown in *DVT*

Question 90

Answer 90

*Saddle* **Pulmonary Embolus**

Question 91

Answer 91

**Medial Hypertrophy** indicating *Pulmonary HTN*

Question 92

Answer 92

**Plexiform Lesions** indicating *Pulmonary HTN*

Question 93

Answer 93

**PNA**

Question 94

Answer 94

**Streptococcus pneumoniae** *most common cause of [CA PNA]*

Question 95

Answer 95

**Palasading Epithelium** indicating TB Lung Granuloma

Question 96

Answer 96

**[Multinucleated Giant Cells]** indicating TB Lung Granuloma

Question 97

Answer 97

**[Amorphic Central Necrosis]** indicating TB Lung Granuloma

Question 98

Answer 98

**Ghon Focus** indicating TB

Question 99

Answer 99

[*Cavitary* **N**on**T**B **M**ycobacteria] ## Footnote *in the setting of Emphysema*

Question 100

Answer 100

[*Bronchiectasis* **N**on**T**B **M**ycobacteria]