Histopath

Question 1

Signet ring cells + linitis plastica

Answer 1

Gastric Carcinoma

Question 2

Perl’s Prussion Blue stain

Answer 2

Haemachromatosis

Question 3

Solar elastosis

Answer 3

Actinic keratosis

Question 4

Congo Red stain

Answer 4

Amyloidosis

Question 5

Heliotrope rash

Answer 5

Dermatomyositis

Question 6

Anti-mitochondrial antibodies

Answer 6

Primary biliary cirrhosis

Question 7

Shepherd’s crook deformity

Answer 7

Varus angulation in fibrous dysplasia

Question 8

‘Chinese letters’ bone formation

Answer 8

Fibrous dysplasia

Question 9

Codman’s triangle

Answer 9

Osteosarcoma or Ewing’s sarcoma

Question 10

‘Cotton wool’ calcification

Answer 10

Enchodroma

Question 11

Anti-topoisomerase antibodies aka anti-Scl-70 antibodies

Answer 11

Systemic scleroderma (also CREST to a lesser degree)

Question 12

Inter-cellular prickles within the lungs

Answer 12

Squamous cell carcinoma

Question 13

Dermatitis herpetiformis

Answer 13

Coeliac disease

Question 14

Needle-shaped crystals which are negatively birefringent under polarised red light

Answer 14

Gout (urate)

Question 15

Red cell casts

Answer 15

Glomerulonephritis or vasculitis

Question 16

White cell casts

Answer 16

Pyelonephritis

Question 17

Kayser-Fleischer rings

Answer 17

Wilson’s

Question 18

Anti Double-stranded DNA

Answer 18

SLE

Question 19

Nutmeg liver

Answer 19

Congestive heart failure

Question 20

St Vitus Dance

Answer 20

Rheumatic heart disease

Question 21

F508 mutation

Answer 21

Cystic Fibrosis

Question 22

Biospy of the gastrointestinal wall reveals…

non-caseating granulomas

or transmural inflammation

or skip lesions and fistulae

Answer 22

Crohn’s

Question 23

Biopsy of the gastrointestinal tract reveals villous atrophy

with crypt hyperplasia.

Answer 23

Coeliac disease

Question 24

salmon-pink plaques with a

silver– white scale

Answer 24

Psoriasis

Question 25

'Oat cell' (lung cancer)

Answer 25

Small cell carcinoma

Question 26

Apple-green birefringence under polarized light and Congo red stain

Answer 26

Amyloidosis

Question 27

Gottron papules

Answer 27

Dermatomyositis

Question 28

Calcium pyrophosphate crystals, polygonal under polarised light

Answer 28

Pseudogout

Question 29

Extra-GI manifestations of arthritis, ankylosing spondylitis, stomatitis, uveitis, pyoderma gangenosum, erythema nodosum

Answer 29

Crohn's disease

Question 30

Anti-tissue transglutaminase antibody, anti-gliadin antibodies, and anti-endomysial antibodies

Answer 30

Coeliac disease

Question 31

IgA deficiency may lead to false negative

Answer 31

Anti-TTG for Coeliac disease

Question 32

'Leather bottle' stomach

Answer 32

Gastric carcinoma

Question 33

Aflatoxin / Aspergillus

Answer 33

Hepatocellular carcinoma

Question 34

Solar elastosis with focal parakeratosis

Answer 34

Actinic (solar) keratosis

Question 35

Aschoff bodies and Anitschkow cells

Answer 35

Rheumatic heart disease

Question 36

Haemoptysis + haematuria

Answer 36

Anti-GBM disease aka Goodpasture's syndrome

Question 37

'Muddy casts'

Answer 37

Acute Tubular Necrosis

Question 38

Breast mouse

Answer 38

Fibroadenoma

Question 39

Which Dylan Thomas novel is set in the fictional town of 'llareggub'?

Answer 39

Under Milk Wood

Question 40

Hodgkin's lymphoma with best prognosis

Answer 40

Lymphocyte Predominant - best Lymphocyte depleted - worst

Question 41

Copper carrying protein deficient in Wilson's disease

Answer 41

Caeruloplasmin

Question 42

1st line investigation for Coeliac

Answer 42

Tissue transglutaminase IgA

Question 43

MIC2 (CD99) antibody

Answer 43

Ewing's sarcoma

Answer 44

Osteoid osteoma

Question 45

'Sunburst' appearance on X-ray

Answer 45

Osteosarcoma / Ewing's sarcoma

Question 46

Most common form of thyroid cancer

Answer 46

Papillary (75-85%), followed by Follicular, then Medullary, then Anaplastic