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History Flashcards

(56 cards)

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1
Q

First recorded successful human blood transfusion

A

James Blundell (1818)

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3
Q

Coagulation of blood arise from the upper liquid part of the blood

A

William Hewson (1770/71)

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5
Q

Ambroise Paré

A

Bec de corbin (pinching instrument)

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6
Q

Described a bleeding disorder in several families ( hemophilia)

A

Dr. JC Otto (1803)

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7
Q

1642

A

Antoine van Leeuwenhoek invented microscope

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8
Q

The term “fibrinogen”

A

Babington (1830)

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10
Q

3 classes of animal matter: Gelatine, albumin, and fibrin

A

Antoine Fourcroy (1788)

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11
Q

First successful while blood transfusion to treat hemophilia

A

Samuel Armstrong Lane and Jamed Blundell (1840)

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12
Q

The term “thrombin”

A

Rudolf Virchow (1856)

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13
Q

The term haemorrhaphilia ( haemophilia)

A

Friedrich Hopff and Dr. Schonlein (1828)

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14
Q

Factors that promote blood clot: venous stasis, vascular wall injury, and hypercoagulability; what is this called?

A

Rudolf Virchow (1856); virchow’s triad

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15
Q

2 preparation of fibrinogen by salt precipitation

A

Prosper Sylvian Denis (1859)

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16
Q

Blood staining was developed, ID 3 types of granulocytes, mast cells, polychromatophilia, and megaloblasts

A

Paul Ehrlich (1878)

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18
Q

Bleeding time test

A

William Duke (1910)

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19
Q

Damaged tissue releases plasminogen activator that activates plasminogen to plasmin

A

MacFallane (1937)

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21
Q

Blood circulation

A

William Harvey (1628)

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22
Q

Twisted tourniquet

A

Morel (1674)

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23
Q

Describes thrombosis and Embolism

A

Rudolf Virchow (1868)

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24
Q

“Thrombokimase”

A

Paul Morawitz (1904)

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25
Q

Coagulation is due to a ferment-like substance (thrombin) which exists in circulating blood as an inactive precursor (prothrombin)

A

Alexander Schmidt (1872)

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26
Q

Fibrin is the result of the interaction between thrombin and fibrinogen

A

Olof Hammarsten (1879/80)

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27
Q

Discovered PLTs

A

Guilio Bizzozero (1882)

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28
Q

Discovered heparin

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A

Jay McLean (1916)

30
Q

Factor XII

Study These Flashcards
A

Hageman (1955)

31
Calcium precipitants inhibit coagulation but can be reversed when sufficient amount was readded
Arthus and Pages (1890)
33
Anti-hemophilic factor (factor VIII)
Arthur Patek and FHL Taylor (1937)
34
Role of tissue in converting prothrombin to thrombin (zymoplastic)
Schimdt
38
Oxalated plasma
Quick (1943)
39
Lab test to evaluate clotting time; name the test; normal value
Lee-white whole blood coagulation time; 5-15 min
40
“Tissue factor” for thrombokinase
Howell (1914)
41
Ppt fibrinogen: diluted plasma + Acetic acid
Mellanby (1909)
42
Dicoumanol was extracted from mouldy sweet clover leaves
1939
43
Factor VII
Owen and Bollman (1948)
44
Factor IX
Stephen Christmas (1952)
45
PT test; other name; normal value
Armand Quick; Quick test; 10.3-13.8 seconds
46
Cryoglobulin as an administrable source of factor VII
J. Pool
47
Described and illustrated blood Platelets
Alexandre Donné (1842)
48
Platelets are derived from megakaryocytes
James Wright (1906)
49
Described minute haemorrhages in the skin in cases of allergic purpura
Schönlein (1837)
50
1st anticoagulant discovered
Sodium citrate
51
Na citrate conc in blood collection for hemostatic procedures
3.2%
52
Roman numerals to name factors
1954
55
Described RBCs and a meshwork with a fibrous texture (fibrin)
Marcello Malphigi (1666)
56
First written reference attributed to human hemophilia
Moses Maimonides (2nd Century AD)
58
Studied aniline dye’s selective action on cells and tissues
Paul Ehrlich (1877)
59
Devised and published a stain for differential staining of blood cells
James Wright (1902)
64
aPTT; normal value
RD Langdell, RH Wagner, and KM Brinkhous; 25-43 seconds (1953)
66
Proaccelerin (factor V)
Paul Owrner (1947)
67
Father of hematology
William Hewson
68
Came up with a purer preparation of fibrinogen due to repeated precipitation with half saturated NaCl
Olof Hammersten (1879/80)
70
the term “Fibrin”
Antoine Fourcroy
71
“Heparin”
Howell and Holt (1918)
72
Presence of nucleated RBCs in the bone marrow sap of humans and rabbits
Franz Ernst Christian Neuman (October 1868)
76
4 factors in coagulation: thrombokinase, prothrombin, fibrinogen and calcium
Paul Morawitz (1905)
84
Specific component of blood capable of initiating coagulation (tissue factor)
Andrew Buchanan(1835/36)
87
RBC appearance
Jan Jacbz Swammerdam (1658)

Hematology2 (3 decks)

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