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Immunology and Serology > History and Milestones in Immunology > Flashcards

History and Milestones in Immunology Flashcards

1
Q

Voltaire

A

variolation (variola - smallpox)

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2
Q

Edward Jenner

A

vaccinia virus (cowpox)

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3
Q

Louis Pasteur

A

vaccines against chicken cholera, anthrax, and rabies

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4
Q

Louis Pasteur

A

live attenuated vaccine (rabies) - from old bacterial cultures

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5
Q

Haeckel

A

phagocytosis

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6
Q

Elie Metchnikoff

A

complete steps of phagocytosis

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7
Q

Emil Von Behring and Kitasato

A

anti-tetanus and anti-diphtheria antitoxins

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8
Q

Robert Koch

A

cutaneous / delayed hypersensitivity (granuloma)

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9
Q

Albert Calmette and Camille Guerin

A

BCG vaccine (for TB)

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10
Q

Gruber and Durham

A

agglutination reactions

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11
Q

Ferdinand Widal

A

Widal test (typhoid fever)

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12
Q

Paul Ehrlich

A

antibody formation theory

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13
Q

Karl Landsteiner

A

ABO blood groups

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14
Q

Paul Portier and Charles Richet

A

anaphylaxis

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15
Q

Almoth Wright, Stephen Douglas, and Joseph Denys

A

opsonins

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16
Q

Von Pirquet and Schick

A

immunity and hypersensitivity relationship

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17
Q

Pfeiffer and Buchner

A

complement mediated cytolysis

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18
Q

Jules Bordet

A

complement

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19
Q

Jonas Salk and Albert Sabin

A

polio vaccine

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20
Q

George Snell, Jean Dausset, Baruj Benacerraf

A

MHC proponents

21
Q

George Snell

A

major histocompatibility complex -> human leukocyte antigen

22
Q

Jean Dausset

A

early pioneer in MHC / HLA study

23
Q

Baruj Benacerraf

A

MHC restriction first demo (immune response genes)

24
Q

Niels Jerne

A

hemolytic plaque assay

25
Q

Niels Jerne

A

early version of clonal selection

26
Q

Peter Medawar

A

acquired immunologic tolerance

27
Q

Rodney Porter

A

protein sequencing (antibody’s polypeptide structure)

28
Q

Rosalyn Yalow

A

radioimmunoassay on peptide hormones

29
Q

Alexander Flemming

A

action of lysozymes

30
Q

Alexander Flemming

A

penicillin (Penicillium notatum)

31
Q

James Gowan

A

adaptive immunity (lymphocytes)

32
Q

Cesar Milstein and Georges Kohler

A

monoclonal antibody formation through hybridoma technology

33
Q

Gerald Edelman

A

immunoglobulin structure

34
Q

Gerald Edelman

A

first complete sequence of antibody

35
Q

Michael Heidelberger

A

quantitative precipitative assay

36
Q

Kendall

A

quantitative precipitative assay studies on antigen-antibody reactions

37
Q

Max Theiller

A

yellow fever vaccine

38
Q

Susumu Tonegawa

A

antibody and TCR diversity

39
Q

Alic Isaacs and Jean Lindemann

A

interferon

40
Q

Luc Montaigner

A

lymphadenopathy associated virus (LAV)

41
Q

Robert Gallo

A

LAV to HIV

42
Q

Mosmann

A

T helper cells (Th1 and Th2)

43
Q

E. Donnall Thomas and Joseph Murray

A

first organ transplant

44
Q

1996-1998

A

Toll Like Receptors (direct phagocytosis)

45
Q

Peter Doherty and Rolf Zinkernagel

A

double recognition of T cells (APC -> MHC)

46
Q

Surface Antibody

A

B lymphocyte receptor

47
Q

T Cell Receptor

A

antigen receptor

48
Q

Mosmann (2001)

A

FOX3p on T-Helper Cells

49
Q

Ian Frazer

A

human papilloma virus vaccine

Immunology and Serology (5 decks)

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