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Timeline Of Immuno Sero > History Of Immuno Sero > Flashcards

History Of Immuno Sero Flashcards

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0
Q

Recognition of “adaptive” protection against disease

A

Egypt & China

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1
Q

Fever

A

Mesopotamia

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2
Q

Anatomic identification of organs

A

Hippocrates

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3
Q

Acquired resistance to poisons

A

Mithridate Eupator, King of Pontus

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4
Q

Four cardinal signs of inflammation

A

Celsus

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5
Q

“Snuff” variolation for smallpox

A

Sung Dynasty, China

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6
Q

Bursa of birds described

A

Fabricius

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7
Q

Lymphoid tissue identified in small intestine

A

Peyer

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8
Q

Observed the positive effects of variolation on the native population and had the technique performed on her own children.

A

Lady Mary Wortley Montagu

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9
Q

First demonstration of vaccination (smallpox vaccination)

A

Edward Jenner

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10
Q

First description of the role of microbes in putrefaction and fermentation

A

Theodore Schwann

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11
Q

Confirmation of the role of yeast in fermentation of sugar to alcohol

A

Charles Cagniard-Latour

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12
Q

First “modern” proposal of the germ theory of disease

A

Jacob Henley

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13
Q

Demonstration of the contagious nature of puerperal fever (childbed fever)

A

Ignaz Semmelweis

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14
Q

Tuberculous granulomas

A

Rokitansky

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15
Q

Langhans Giant Cells

A

Langhans

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16
Q

Confirmation of the role of microbes in fermentation

A

Louis Pasteur

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17
Q

Theory that bacterial virulence could be attenuated by culture in vitro and used as vaccines. Proposed that live attenuated microbes produced immunity by depleting host of vital trace nutrients.

A

Louis Pasteur

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18
Q

Phagocytosis

A

Ernst Haeckel

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19
Q

First aseptic practice in surgery using carbolic acid

A

Joseph Lister

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20
Q

First demonstration that microbes can cause disease ANThrax

A

Robert Koch

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21
Q

Mast Cells

A

Paul Ehrlich

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22
Q

Confirmation and popularization of the germ theory of disease

A

Louis Pasteur

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23
Q

Birth of cellular pathology

A

Virchow

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24
Cellular theory of immunity via phagocytosis by macrophage and microphages (polymorphonuclear leukocytes)
Elie Metchnikoff
25
Introduction of the concept of "therapeutic vaccination".
Louis Pasteur
26
Anti-rattlesnake venom discovered
Sewall
27
Identification of bacterial toxins (Diptheria bacillus)
Pierre Roux and Alexandre Yersin
28
Bactericidal action of blood
George Nuttall
29
Demonstration of antibody activity against diphtheria and tetanus toxins. Beginning of humoral theory of immunity.
Emil von Behring and Shibasaburo Kitasato
30
Demonstration of cutaneous (delayed type) hypersensitivity
Robert Koch
31
Use of live bacteria and bacterial lysates to treat tumors (Coley's Toxins)
William B. Coley
32
Bacteriolysis
Richard Pfeiffer
33
An antibacterial, heat-labile serum component (complement) is described
Jules Bordet
34
Antibody formation theory "side chain theory" "horror autotoxicus"
Paul Ehrlich
35
Blood groups
Karl Landsteiner
36
Transplantable tumors
Carl Jensen and Leo Loeb
37
Immediate hypersensitivity (anaphylaxis)
Paul Portier and Charles Richet
38
Intermediate hypersensitivity, the "Arthus reaction"
Maurice Arthus
39
Opsonization
Almroth Wright & Stewart Douglas
40
"Serum sickness" allergy
Clemens Von Pirquet and Bela Schick
41
Successful organ transplantation
Correl and Guthrie
42
Coined the word "allergy"
Clemens Von Pirquet
43
Coined the term "immunochemistry"
Svante Arrhenius
44
Inheritance of ABO blood groups
Emil von Dungern & Ludwik Hirzfeld
45
Viral immunology theory
Peyton Rous
46
2nd demonstration of filterable agent that caused tumors
Peyton Rous
47
Genetics theory of tumor transplantation
Clarence Little
48
Inbred Mouse Strains
Clarence Little and Leonell Strong
49
Hapten
Karl Landsteiner
50
Cutaneous Allergic Reactions
Carl Prausnitz and Heinz Kustner
51
Found lysozyme and penicillin
Alexander Fleming
52
Reticuloendothelial system
Aschoff
53
Chemical mediators of inflammation
Lewis
54
Isolation of pure antibody preparation
Lloyd Felton and GH Bailey
55
Quantitative precipitin reaction
Heidelberger
56
Identification of the H-2 antigen in mice
Peter Gorer
57
Identified Gammaglobulin
Tiselius and Kabat
58
Antigen-Antibody binding hypothesis
John Marrack
59
Identification of the Rh antigens
Karl Leindsteiner & Alexander Weiner
60
Hemolytic disease of the newborn (Rh antigens)
Philip Levine
61
Immunoflourescence technique
Albert Coons
62
Anaphylaxis
Karl Landsteiner and Merill Chase
63
Adjuvants
Jules Freund and Katherine McDermott
64
Hypothesis of Allograft rejection
Peter Medawar
65
Passive transfer of cell mediated immunity
Merill Chase
66
Identification of mouse MHC (H2)
George Snell & Peter A. Gorer
67
Twins do not demonstrate transplant rejection
Owen
68
Antibody production in plasma B cells
Astrid Fagraeus
69
Growth of polio virus in tissue culture, neutralization with immune sera, and demonstration of attenuation of neurovirulence with repetitive passage
John Enders, Thomas Weller, Frederick Robbins
70
Immunological tolerance hypothesis
Macfarlane Burnet & Frank Fenner
71
Discovery of Suppressor T cells
Richard Gershon and K Kondo
72
Discover of agammagobulinemia (antibody immunodeficiency)
Ogden and Bruton
73
Vaccine against yellow fever
1951
74
Graft vs. Host disease
Morton Simonsen and WJ Dempster
75
Immunological tolerance hypothesis
Rupert Billingham, Leslie Brent, Peter Madawar, Milan Hasek
76
Discovery of histamine in mast cells
James Riley and Geoffrey West
77
Clonal Selection Theory
Niels Jerne, David Talmage, Macfarlane Burnet
78
Discovery of interferon
Alick Isaacs and Jean Lindermann
79
Induction of auto immunity in animals
Ernest Witbsky et al
80
Discovery of human leukocyte antigens
Jean Dausset and Snell
81
Discovery of antibody structure
Gerald Edelman and Rodney Porter
82
Discovery of lymphocyte circulation
James Gowans
83
Discovery of lymphocyte "blastogenic transformation" and proliferation in response to mitogenic lectins-phytohemagglutinin (PHA)
Peter Nowell
84
Discovery of thymus involvement in cellular immunity
Jacques Miller
85
Demonstration that glucocorticoids inhibit PHA-induced lymphocyte proliferation
Peter Nowell
86
Classification of immune mechanism
Gel and Coombs
87
Development of the plaque assay for the enumeration of antibody-forming cells in vitro
Niels Jerne & Albert Nordin
88
Antibody idiotypes
Jaques Odin et al
89
T and B cell cooperation in immune response
Anthony Davis
90
Mixed lymphocyte reaction
Bain, Vas et al

Timeline Of Immuno Sero (1 decks)

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