History of Immunology

Question 1

When and who discovered smallpox vaccination ?

Answer 1

1798 Jenner

Question 2

When and who discovered phagocytosis ?

Answer 2

1862 Haeckel

Question 3

When and who discovered live, attenuated chicken cholera and anthrax vaccine ?

Answer 3

1880-1881 Pasteur

Question 4

When and who discovered cellular immunity through phagocytosis ?

Answer 4

1883-1905 Metchnikoff

Question 5

When and who discovered therapeutic vaccination and first report of live “attenuated” vaccine for rabies ?

Answer 5

1885 Pasteur

Question 6

When and who discovered humoral theory of immunity proposed ?

Answer 6

1890 Von Behring, Kitasata

Question 7

When and who discovered demonstration of cutaneous (delayed-type) hypersensitivity ?

Answer 7

1891 Koch

Question 8

When and who discovered passive immunization ?

Answer 8

1894 Emil Roux

Question 9

When and who discovered antibody formation therapy ?

Answer 9

1900 Ehrlich

Question 10

When and who discovered immediate-hypersensitivity anaphylaxis ?

Answer 10

1902 Portier, Richet

Question 11

When and who discovered Arthus reaction of intermediate hypersensitivity ?

Answer 11

1903 Arthus

Question 12

When and who discovered hypothesis of antigen-antibody binding ?

Answer 12

1938 Marrack

Question 13

When and who discovered hypothesis of allograft rejection ?

Answer 13

1944

Question 14

When and who discovered development of polio vaccine ?

Answer 14

1949 Salk, Sabin

Question 15

When and who discovered vaccine against yellow fever ?

Answer 15

1951 Reed

Question 16

When and who discovered graft-versus-host reaction ?

Answer 16

1953

Question 17

When and who discovered clonal selection theory ?

Answer 17

1957 Burnet

Question 18

When and who discovered interferon ?

Answer 18

1957

Question 19

When and who discovered Human Leukocyte Antigens (HLAs) ?

Answer 19

1958-1962

Question 20

When and who discovered T-cell and B-cell cooperation in immune response ?

Answer 20

1964-1968

Question 21

When and who discovered identification of antibody molecule ?

Answer 21

1972 Edelman, Porter

Question 22

When and who discovered first monoclonal bodies ?

Answer 22

1975 Köhler

Question 23

When and who discovered the existence of genes that control graft rejection ?

Answer 23

1980 George Snell

Question 24

When and who discovered the technique to identify molecules found on the surface of cells, thereby decreasing graft rejection ?

Answer 24

1980 Jean Dausset

Question 25

When and who discovered Inheritance of an animal’s ability to make antibodies to defined molecules; ability to respond to an antigen determining resistance and susceptibility ?

Answer 25

1980 Baruj Benacerraf

Question 26

When and who discovered the identification of genes for T-cell receptor ?

Answer 26

1985-1987

Question 27

When and who discovered monoclonal hepatitis B vaccine ?

Answer 27

1986

Question 28

When and who discovered Th1 versus Th2 model of T-helper cell function ?

Answer 28

1986 Mosmann

Question 29

When and who discovered kidney and bone marrow organ transplantation ?

Answer 29

1990 Murray, Thomas

Question 30

When and who discovered the identification of toll-like receptors ?

Answer 30

1996-1998

Question 31

When and who discovered FOXP3, the gene directing regulatory T-cell development ?

Answer 31

2001

Question 32

When and who discovered the development of human papilloma virus vaccine ?

Answer 32

2005 Frazer

Question 33

Who was the Nobel prize winner on the research of Serum antitoxins ?

Answer 33

Emil Von Behring 1901

Question 34

Who was the Nobel prize winner on the research of Cellular immunity in TB ?

Answer 34

Robert Koch 1905

Question 35

Who was the Nobel prize winner on the research of phagocytosis ?

Answer 35

Elie Metchnikoff 1908

Question 36

Who was the Nobel prize winner on the research of immunity ?

Answer 36

Paul Ehrlich 1908

Question 37

Who was the Nobel prize winner on the research of anaphylaxis ?

Answer 37

Charles Richet 1913

Question 38

Who was the Nobel prize winner on the research of complement ?

Answer 38

Jules Bordet 1919

Question 39

Who was the Nobel prize winner on the research of Human blood group antigens ?

Answer 39

Karl Landsteiner 1930

Question 40

Who was the Nobel prize winner on the research of discovery of immunologic tolerance ?

Answer 40

Macfarlane Burnet, Peter Medawar 1960

Question 41

Who was the Nobel prize winner on the research of structure of antibodies ?

Answer 41

Gerald Edelman, Rodney Porter 1972

Question 42

Who was the Nobel prize winner on the research of Radioimmunoassay ?

Answer 42

Rosalyn Yalow 1977

Question 43

Who was the Nobel prize winner on the research of Major histocompatibility complex ?

Answer 43

George Snell, Jean Dausset, Baruj Benacerraf 1980

Question 44

Who was the Nobel prize winner on the research of immunoregulation ?

Answer 44

Niels Jerne 1984

Question 45

Who was the Nobel prize winner on the research of Monoclonal antibody ?

Answer 45

Georges Koehler, Cesar Milstein 1984

Question 46

Who was the Nobel prize winner on the research of antibody diversity ?

Answer 46

Susumu Tonegawa 1987

Question 47

Who was the Nobel prize winner on the research of transplantation ?

Answer 47

Edward Donnall Thomas, Joseph Murray 1991

Question 48

Who was the Nobel prize winner on the research of Cytotoxic T cell recognition of virally infected cells ?

Answer 48

Peter Doherty, Rolf Zinkernagel 1996

Question 49

Who was the Nobel prize winner on the research of prions ?

Answer 49

Stanley Prusiner 1997

Question 50

Who was the Nobel prize winner on the research of signal transduction ?

Answer 50

Gunter Blobel 1999

Question 51

Who was the Nobel prize winner on the research of HIV ?

Answer 51

Françoise Barré – Sinoussi, Luc Montagnier 2008