HIV Flashcards
(52 cards)
what is HIV
depletion CD4 lymphocytes- progressive immunosuppression, susceptibility to opportunistic infections and cancer
what is HIV
depletion CD4 lymphocytes- progressive immunosuppression, susceptibility to opportunistic infections and cancer
when does seroconversion occur
2-4 weeks after infection
what CD4 is when AIDs occurs
where does HIV bind
via gp120 glycoprotein to CD4 receptors on T helper, monocytes, macrophages, neural cells
signs seroconversion
primary infection. transient illness. fever, malaise, myalgia, pharyngitis, maculopapular rash, meningoencephalitis
what follows seroconversion
asymptomatic infection. 30% have persistent generalised lymphadenopathy
definition of AIDs
HIV + indicator of disease
definition of AIDs
HIV + indicator of disease
when does seroconversion occur
2-4 weeks after infection
what CD4 is when AIDs occurs
where does HIV bind
via gp120 glycoprotein to CD4 receptors on T helper, monocytes, macrophages, neural cells
If recent infection what tests can be done (if HIV Ab -ve)
HIV RNA or core p24 antigen; or check at 6 weeks and 3 months
what follows seroconversion
asymptomatic infection. 30% have persistent generalised lymphadenopathy
first line treatment TB
isoniazid, pyrazinamide, rifampicin, ethambutol
definition of AIDs
HIV + indicator of disease
time scale HIV to AIDs
8 years
timescale ARC to AIDs
2 years
time scale AIDs to death
2 years
diagnosis
serum or salivary HIV-Ab by ELISA
other pathogens affecting lungs in HIV
M avium intracellulare, CMV,HHV8 (Kaposis sarcoma), lymphoid intersititial pneumonitis
in patient who is HIV +ve and cough, fever, night sweats, weight loss what is it until proven otherwise
TB
first line treatment TB
isoniazid, pyrazinamide, rifampicin, ethambutol
treatment CMV retinitis
ganciclovir containing intra ocular implants
