HIV and AIDS

Question 1

Describe the genome structure of HIV-1. How are complex retroviruses
distinguished from simple retroviruses?

Answer 1

-complex encodes for accessory protiens.
-4 layers: envelope, matrix, capside and nucleocapsid
-+ssRNA, 2 copies per virion
-

Question 2

Describe the reverse transcription process of HIV-1 and the various functions of reverse transcriptase

Question 3

The genetic makeup of an individual’s immune system can be an important
determinant in the development and progression of AIDS. Why?

Question 4

Discuss the three size classes of mRNAs generated by HIV-1.

Question 5

At the molecular level, how is HIV latency controlled?

Question 6

Besides gap, pol and env proteins, HIV-1 also encodes several auxiliary
proteins. Describe the function of some of these accessory proteins.

Question 7

A number of cellular proteins, including APOBEC3G, are incorporated into
HIV virions. What role does APOBEC3G play for HIV?