HIV Life Cycle

Question 1

step 1

Answer 1

gp120 binds to CD4 receptor of T-cell surface

Question 2

step 2

Answer 2

gp41 and gp120 bind to coreceptors CCR5/CXCR4 and the virus uncoats in the cell

Question 3

step 3

Answer 3

reverse transcriptase copies a complementary strand of DNA from RNA, viral RNA is degraded by RNAse H, which cleaves RNA from hybrid DNA

Question 4

step 4

Answer 4

viral DNA enters through pores and enters host cell nucleus

Question 5

Step 5

Answer 5

integration of viral DNA into the host genome for viral mRNA production

Question 6

step 6

Answer 6

production of viral mRNA from host cell genome by host cell’s RNA polymerase

Question 7

step 7

Answer 7

mRNA is released to cytoplasm and the manufacture of various viral proteins are started

Question 8

step 8

Answer 8

assembly of viral proteins to form virion and virus maturation by HIV protease

Question 9

step 8 A

Answer 9

viral proteins are produced as a single large polyprotein precursor in preparation for its assembly into daughter particles

Question 10

Step 8 B

Answer 10

polyprotein precursor envelopes with gp120 and gp41 and undergoes cleavage by HIV protease

Question 11

Step 8 C

Answer 11

formation of virions capable of invading other T-cells and repeating the cycle

Question 12

Step 9

Answer 12

viral budding out of host cell which leaves behind a hole which cells the cell