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Flashcards in Hmb Deck (11)
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1

Monosomy

Monosomy 21
Turner syndrome xo

2

Turner syndrome

XO
Sterile
99% not born

3

Trisomy

Trisomy 21 Down syndrome
Trisomy 18 Edward syndrome
Trisomy 13 patau syndrome
XXY Klinefelter syndrome
XYY fertile
XXX fertile

4

Down syndrome

Trisomy 21
Female fertile
Male infertile
Life expectancy 40-60
Mather age has dominant effect

5

Edward syndrome

Trisomy 18
Mentally abnormal

6

Patau syndrome

Trisomy 13
Mental abnormality
Low life exp

7

Molecular mechanisms on epigenetic

DNA methylation at CpG islands = repress gene expression
Covalent modification of histone
Non-covalent modification of histones (chromatin remodelling)
Non-coding RNA - transcriptional silencing (RNAi)

8

AAV

Long term expression
Non toxic
Carry small gene
Infect both dividing and non dividing

9

AV

Large gene carried
Transient expression
Evoke immune response
Infect both dividing and non dividing cell

10

Herpes

Long term expression
Infect neuroglia (for brain tumour)

11

Retrovirus

Stable but imprecise integration
Long term expression
Non toxic
Only atk dividing cell