Hodgkin's Lymphoma Flashcards
1
Q
Hodgkin’s Lymphoma
A
Reed-Sternberg cells; CD15/30 (+)
-2 mirror image nuclei (“owl eyes”), each with an eosinophilic nucleolus, surrounded by a clear halo; of B-cell origin.
The RS cells secrete cytokines, leading to fever, weight loss, night sweats and itching.
2
Q
Nodular Sclerosis HL
A
Fibrous thickening of anterior mediastinal and either cervical or supraclavicular lymph nodes.
Lacunar type RS cells seen: RS cell in big spaces.
Excellent prognosis
3
Q
Lymphocyte-rich HL
A
Lots of lymphocytic and histiocytic (“popcorn”) cells are present. These cells are CD19/20 (+), but CD 15/30 (-)
Good prognosis
4
Q
Lymphocyte-depleted HL
A
Worst prognosis
5
Q
Mixed-cellularity HL
A
Abundant eosinophils due to IL-5. Associated with Epstein Barr Virus
