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Flashcards in Homeostasis Deck (20):
1

What is meant by homeostasis?

Maintenance of a constant internal environment, with all processes working optimally.

2

Describe the process of negative feedback.

-Magnitude of change of variable is monitored by a receptor
-Info fed back to integrating system
-Compared to reference level
- Difference between actual level and reference level generates a signal
-Signal fed back to effector mechanism
-Brings about response to restore variable to reference level

3

What is the difference between negative and positive feedback?

In negative feedback, a deviation from a reference range brings about a response to return the variable to the reference range.
In a feedforward mechanism, a deviation of a variable from a reference range generates a response which leads to a further deviation from that reference range.

4

What is the difference between negative feedback mechanisms and feed-forward mechanisms?

Negative feedback mechanisms can only produce a response to correct deviation from a certain range after this deviation has occurred.
Feed-forward mechanisms can PREDICT deviation from the reference range and bring about a response to correct if BEFORE it has actually happened.

5

What proportion of total body water is Extracellular fluid?

1/3

6

What proportion of total body water is Intercellular fluid?

2/3

7

What two compartments of body fluid make up the extracellular fluid of the body?

Plasma and interstitial fluid

8

Why are females considered 'less wet'?

They have a higher proportion of fat: muscle tissue. Fat tissue has a lower water content than muscle.

9

What is the main difference in constituents of the blood plasma and interstitial fluid?

Presence of plasma proteins in blood plasma and their absence in ISF.

10

How is the volume of distribution calculated?

Substance injected that will stay in only one body part
Vol= (mass injected- mass removed)/ conc.

11

What three body fluid compartments can be measured directly?

Plasma
ECF
Total Body Water

12

How is the volume of plasma in the body measured?

Using dyes or radioactive labels attached to plasma proteins

13

How is the volume of ECF in the body measured?

Using radioactive ions, insulin or sucrose

14

How is the volume of Total Body Water measured?

Using a loading dose of radioactive water (D20)

15

How is the volume of ISF in the body calculated?

ISF= ECF - PV

16

How is the volume of ICF in the body measured?

ICF= TBW- ECF

17

By what mechanism are most physiological responses triggered?

Negative feedback

18

What is the average volume of water found in the body? i.e. Average TBW volume

42L

19

What Is the average ECF found in the body?

14L

20

What Is the average ICF found in the body?

28L