Hot Topics

Question 1

Mag sulphate in EPTL

?NNT to prevent CP

Answer 1

63

Question 2

Head cooling

?Toby trial results

Answer 2

Follow up study 6-7y (UK) 2014: NNT to prevent death or IQ

Question 3

Oxygen at birth - ?%of 02 for term and preterm?

Answer 3

RA for neonates, 30%for

Question 4

Benefits of caffeine?

Answer 4

Less PDA, less surgery for PDA, decreased CP! (First drug to reduce CP in neonates)

Question 5

Results of Manley trial night flow 2013

Answer 5

HF not inferior to CPAP when being extubated

Question 6

BOOST and SUpport trial outcomes

Answer 6

Boost 1: >32 weeks
Boost 2 (Aus, NZ, Eng) :

Question 7

Probiotic trial Al Faleh 2014

Answer 7

Reduced inc NEC in BW

Question 8

Volume Guarantee ventilation

Answer 8

Reduced risk CLD compared to pressure limited ventilation

Question 9

EPO in neonates (Ohls at al 2014$

Answer 9

Neuroprotector (better neurodevelopmental outcomes)

Question 10

Australasia survival of babies adm to NICU
? 23w
?At 24w
?at 25w

Answer 10

44% (

Question 11

Inhaled NO in 25w baby?

Answer 11

Some immediate improvement in oxygenation but not sustained

Question 12

Caffeine and preterm babies

Answer 12

Reduces CLD by nearly 40%

Less Surg for PDA

Question 13

Repeat course of antenatal steroids 1 week after first course

Answer 13

2nd dose reduces RDS by 20%

Only downside was a poorer weight gain

Question 14

?position renal arteries and sup mesenteric arteries

Answer 14

L1-2

Question 15

?position of coeliac axis

Answer 15

T12-L1

Question 16

?position of inf mesenteric arteries

Answer 16

L3-4

Question 17

Is CPAP associated with increased pneumothorax?

Answer 17

Yes (COIN trial, cpap vs ventilation, spont pTx 9% versus 3%)

Question 18

?appearances of CXR 25w

Answer 18

HMD white!

ground glass, small volume lungs, air bronchograms

Question 19

Duodenal atresia

Answer 19

Double bubble AXR

Question 20

Pyloric stenosis ? Time of presentation

Answer 20

3-6w

Question 21

Protracted vomiting of stomach will produce

Answer 21

Hypochloraemic, hypokalaemic, metabolic alkalosis

Question 22

?%of duodenal atresia associated with DS

Answer 22

30% will have Trisomy 21 (strongly associated)

Question 23

Rate of increased need for some special ed at some point for a
?28-32/40 versus term control
?for 24-27w
33-36
37 (late pre termer at increased interest)

Answer 23

2.5x
7x increased
1.5x
1.4x

Irish study.

Question 24

NEC

?AXR

Answer 24

Pneumatosis

Fear PORTAL GAS

Question 25

?diagnostic tool for malrotation

Answer 25

USS may show mal position of SMV with respect to SMA

Question 26

?does indomethacin increase rate of nec and bowel perf ? Probiotics and lactoferrin protective for NEC ?complete course antenatal steroids reduce risk of NEC Slower rates of feed increase

Answer 26

No difference Yes Yes (halves rate of NEC, and repeated course improves short term outcomes) No difference

Question 27

Free air sign AXR

Answer 27

Silvers sign air on either side of Falciform ligament | Air on either side of bowel = riglers sign

Question 28

?50th Centile for BW at 24w

Answer 28

~650g

Question 29

?causes for neonatal chorioretinitis

Answer 29

Toxo, CMV, syphilis

Question 30

? Inheritance of retinoblastoma

Answer 30

AD with incomplete penetrance

Question 31

%success rate of laser therapy for ROP stage 3

Answer 31

50% reduced risk of detachment

Question 32

Gram positive bacilli in CSF neonate

Answer 32

``` Listeria 30% Penicillin resistant Partially cooked stuff/deli meats SIADH, low serum sodium and high urinary Na Meningitis more common late onset >1w Salmon rash ```

Question 33

Blueberry muffin

Answer 33

CMV or toxo

Question 34

Lactoferrin ?%of iron absorption from human and formula milk? Major whey protein present in Breast milk

Answer 34

Enables 50%abs iron from HM, 10%from FM | Proven use in reducing NEC

Question 35

?main immune function of lactoferrin | ?loss of fxn on freezing/pasterurisation

Answer 35

Bacteriostatic | Looses 65%of function!