HR block 6 part 1 Flashcards
What cortex covers most of the cortical surface?
neocortex
Which cortex is the most primitive?
archicortex
What cortex has 3 laminae?
archicortex
What cortex has 6 laminae?
neocortex
What cortex has 4 laminae?
paleocortex
What are stellate cells important for?
local circuit processing
What do pyramidal cells do?
provide output axons
Cells above and below each other perpendicular to the pial surface have ___ functional properties.
common
What layer do thalamic inputs go to?
4
Where does layer 2 project to?
other cortical areas
Where does layer 3 project to?
opposite hemisphere
Where does layer 5 project to?
subcortical structures
Where does layer 6 project to?
feedback to thalamus
What is Brodmann’s cytoarchetectonics based on?
histological variation in thickness and cell density
What is an association cortex?
areas that can’t be defined with a simple motor or sensory function
What are association fiber bundles?
connect cells within the same hemisphere
What does the superior longitudinal fasciculus connect?
fronto - parieto - occipital
What does the uncinate fasciculus connect?
temporo-frontal
What does the inferior longitudinal fasciculus connect?
occipito-temporal
What fibers connect one hemisphere to another?
commissural fibers
What is the major commissural fiber?
corpus callosum
What does the anterior commissure connect?
opposite temporal lobes
What does the posterior commissure connect?
opposite pretectal areas
What fibers connect different areas of the brain?
projection bundles
What is the largest projection bundle?
internal capsule(thalamus-cortex cortex-thalamus cortex-brainstem/spinal cord)
What does the fornix connect?
hippocampus to mammilary body in the diencephalon
What does the hippocampus do?
transfer memory to long term storagespatial orientation
Which lobe is the hippocampus in?
medial temporal lobe
What kind of cortex is the hippocampus?
archicortex
Where is the diencephalon?
between brainstem and telencephalon
What does the thalamus do?
takes inputs to the cortex
What input that goes to the cortex bypasses the thalamus?
olfactory input
What bounds the thalamus laterally?
internal capsule
What are the two halves of the thalamus separated by?
3rd ventricle
Where does the thalamic lateral geniculate nucleus project to?
visual cortex
Where does the medial geniculate nucleus project to?
auditory cortex
Where does the thalamic ventral-posterior nuclei project to?
somato-sensory
Where does the thalamic ventral anterior-ventral lateral nuclei project to?
premotor and motor cortex
Where does the thalamic anterior nucleus project to?
cingulate gyrus
Where does the thalamic mediodorsal nucleus project to?
frontal association cortex
Where does the thalamic lateral posterior pulvinar nuclei project to?
parietaloccipitaltemporal association cortex
What property of thalamic nuclei provides the EEF oscillating circuit?
each thalamic nuclei receives feedback from the same cortical area it projects to
What do reticular nuclei contain?
inhibitory interneurons that adjust thalamic signaling
Where is CNII?
ventral diencephalon
Where is CNIII
ventral midbrain
Where is CN IV?
dorsal midbrain
Where is CN V?
over ventrolateral pons
Where is CN VI?
ventral medulla
Where is CN VII?
lateroventral medulla
Where is CN VIII?
lateral medulla
Where is CN IX?
lateral medulla
Where is CN X?
lateral medulla
Where is CN XI?
lateral surface of cervical spinal cord
Where is CN XII?
ventral caudal medulla
What is the nuclei for CNI?
anterior olfactory nucleus
What is the nuclei for CN II?
lateral geniculate nucleus
What is the nucleus for CN III?
oculomotor nucleusedinger-westphal nucleus
What is the nuclei for CN IV?
trochlear nucleus
What is the nuclei for CN V?
principal sensory trigeminal nucleusspinal trigeminal nucleusmesencephalc trigeminal nucleustrigeminal motor nucleus
What is the nuclei for CN VI?
abducens nucleus
What are the 3 nuclei for CN VII?
facial nucleussolitary nucleussuperior salivary nucleus
What is the nuclei for CN VIII?
vestibular nucleicochlear nuclei
What are the 3 nuclei for CN IX?
nucleus ambiguusinferior salivary nucleussolitary nucleus
What are the 3 nuclei for CN X?
nucleus ambiguusdorsal motor vagal nucleussolitary nucleus
What is the nucleus for CN XI?
nucleus ambiguusspinal accessory nucleus
What is the nucleus for CN XII?
hypoglossal nucleus
Which is the CNV nuclei?
red
Which is the CN III nuclei?
top yellow
Which is the CN IV nuclei?
yellow second from the top
Which is the CN VI nuclei?
yellow in middle
Which is the CN X nuclei?
purple at bottom
Which is the Edinger-Westphal nuclei?
purple at top
Which is the CNVIII nuclei?
green
Which is the nucleus solitarius?
blue at bottom
In the neural tube, alar (dorsal) plate cells give rise to ___ neurons.
sensory
In the neural tube, basal palte cells (ventral) give rise to ___ neurons.
motor
CN nuclei are located from medial to lateral relative to functional role:
somatic motorvisceral motorbranchial motorvisceral sensorygeneral somatic sensoryspecial somatic sensory
Which CN nuclei are somatic motor?
oculomotortrochlearabducenshypoglossal
Which CN nuclei are branchial motor?
trigeminal motorfacialnucleus ambiguusspinal accessory
Which CN nuclei are visceral motor?
edinger-westphalsuperior/inferior salivatorydorsal motor nucleus of vagusnucleus ambiguus
Which CN nuclei are general sensory?
mesencephalicprincipalspinal
Which CN nuclei are special sensory?
vestibularcochlear
Which CN nuclei is visceral sensory?
nucleus of the solitary tract
Which CN are only sensory?
IIIVIII
Which CN are only motor?
IIIIVVIXIXII
What does CNI do?
sense of smell
What does CNII do?
vision
What does CNIII do?
eye movementspapillary constriction and accommodationmuscles of eyelid
What does CNIV do?
eye movements
What does CNV do?
somatic sensation fromf ace, mouth, cornea, mastication muscles
What does CNVI do?
eye movements
What does CNVII do?
controls facial expressiontaste from anterior tonguelacrimal and salivary glands
What does CN VIII do?
hearingsense of balance
What does CN IX do?
sensation from pharynxtaste from posterior tonguecarotid baroreceptors
What does CN X do?
autonomic functions of gutsensation from pharynxmuscles of vocal cordsswallowing
What does CN XI do?
shoulder and neck muscles
What does CNXII do?
movements of tongue
What is the clinical test for CNI?
test smell with standard odor
What is the clinical test for CNII?
measure acuity and integrity of visual field
What is the clinical test for CNIII?
test eye movementlook for ptosispupillary dilation
What is the clinical test for CNIV?
can’t look down when eye abducted
What is the clinical test for CNV?
test sensation on facepalpate masseter muscles and temporal muscle
What is the clinical test for CNVI?
can’t look laterally
What is the clinical test for CNVII?
Test facial expression plus taste on anterior tongue
What is the clinical test for CNVIII?
test audition with tuning forkvestibular function with caloric test
What is the clinical test for CNIX?
test swallowingpharyngeal gag reflex
What is the clinical test for CNX
test swallowingpharyngeal gag reflexhoarseness
What is the clinical test for CNXI?
test sternocleidomastoid and trapezius M
What is the clinical test for CNXII?
test deviation of tongue during protrusion
What is the prominent CN nuclei at the caudal medulla?
spinal nucleus of CNV
What neurologic symptoms does lesion to nucleus ambiguous present?
difficult swallowinghoarse voice
What nuclei are present at the rostral medulla?
cochlearmedial and lateral vestibularsolitary tract
What two prominent motor nuclei are at the caudal pons?
abducensfacial
What CN nuclei is present at the middle pons?
CN V motor and sensory
What CN nuclei are present at the midbrain level?
trochlearoculomotorEdinger-Westphal
Where do mechanoreceptors go after entering the spinal cord?
layer 4 interneurons -> local reflexipsilateral dorsal column to ascend
What structure do DCL second order axons rise in?
medial lemniscus
What 3sensations are transmitted via DCL?
touchpressureproprioception
DCL has ___ lateral inhibition.
strong
In the dorsal column, lower limb sensations rise medial/lateral.
medial
What vertebral level is the dorsal nucleus of Clarke?
thoracic
Where do dorsal nuclei of Clark neurons go?
ipsilaterally to the cerebellum via the dorsal spinocerebellar tract to inferior cerebellar peduncle
What does the cuneate fasciculus carry?
DCL from arm
Where do DCL axons first synapse?
dorsal column nuclei at caudal medulla
What DCL fibers decussate at the caudal medulla level?
arcuate fibers to the medial lemniscus
At the medulla level medial lemiscus carries mechanoceptive information from which side of the body?
contralateral
At the level of the pons, what does the medial lemniscus arm/feet orientation look like?
feet lateralarm medial
How does mechanoreceptor sensation frmo the head enter the brain?
trigeminal ganglion to ponssynapse in principal nucleus of trigeminal complexcross over to join medial lemniscus
Where is the second DCL synpase?
caudal thalamus at ventral posterior nuclei
Where do DCL axons go after the thalamus?
posterior limb of the internal capsule to post-central gyrus
What are the 3 main Brodman’s areas in the post-central gyrus?
3a - muscle proprioceptors3b - skin1 - rapid receptors2 - deep tissue mechanoreceptors
Sacral axons enter the anterolateral tract at this position.
lateral
What 2 receptors enter the dorsal horn and ascend or descend a level?
nociceptorsthermoreceptors
Where is the first ALS synapse?
dorsal horn
How does head nociception enter the ALS?
enter at ponstravel to caudal medulla ins pinal trigeminal tractsynapse and cross over to contralateral ALS
C fibers compose what part of the ALS?
paleospinothalamicdeep, aching, poorly localized pain
What fibers make up the neospinothalamic ALS?
A delta
What part of the brain processes the emotional aspect of pain?
anterior cingulate gyrus
What does the spinoreticular pathway do?
ALS component that ends in brainstem reticular centers to mediate reflex response to pain
What nucleus provides analgesia?
periaqueductal grey
Descending pathway for analgesia starts at the PAG and goes to?
nucleus raphe in the medulla
What does nucleus raphe magnus do?
via dorsolateral fasciculussynapse at dorsal horn to activate enkephalin interneurons
What is the major projection pathway from M1?
corticospinal (pyramidal)
pyramidal axon breakdown:% from M1% rostral to M1_% from S1
303040
How do the pyramidal tract axons reach the thalamus?
posterior limb of internal capsule
How does the corticospinal tract go through the midbrain?
middle 1/3 of the cerebral peduncle
What tract innervates the cranial motor nuclei?
corticobulbar
Where is the red nuclei?
midbrain
The red nuclei receives synaptic input from M1 and gives rise to __?
rubrospinal projections
Most red nuclei axons end __.
cervical levels
Most corticospinal axons synapse at __.
Rexed’s layer interneurons (VI - VIII)
Corticospinal axons usually __ flexors.
facilitate
What is the orientation of CST axons in the internal capsule from anterior to posterior?
face arm trunk leg
What % of CST axons decussate at the medulla?
90%
What do rubrospinal neurons regulate?
rate of force developmentspeed of movement
Where does somatosensory feedback to M1 neurons come from?
S1 cortex and ventral posterolateral nucleus
What do lesions to SMA cause?
basal ganglia input lackingcan’t use both hands together
What atrophies in Pick’s disease?
frontotemporal lobes
What degenerates in ALS?
alpha motorneurons
List 3 symptoms of upper motor neuron injury:
weaknesshyperactive deep reflexBabinski’s
List 3 symptoms of lower motor neuron injury:
paralysisdecreased superficial and deep reflexsevere muscle atrophy
Define spasticity:
increased tone and stretch reflexes
What motor neurons does the reticulospinal tracts affect?
gammaextensor inhibition
What function does the medullary reticular formation have?
inhibit extensors
What function does the pontine reticular formation have?
facilitates extensors
What causes spastic paralysis in upper motor neuron lesions?
extensor facilitationhigh gamme motor neuron input
In spasticity, resistance is greatest for what muscles?
antigravity muscles
What is Babinski’s sign?
After a strong stroke to the plantar surface of the foot, dorsiflexing.
Where do rubrospinal axons originate?
red nucleus
Where does the reticulospinal pathway originate?
reticular formation
Where does the tectospinal pathway originate?
superior colliculi
What does the vestibule detect?
linear accelerations
What do the semicircular canals detect?
angular acceleration
What determines hair cell depolarization?
stereocilia bending towards kinocilia
How are semicircular canals stimulated?
hair cells in the ampulla are bent by fluid movement
In the utricle, kinocilia are directed __ the striola.
towards
In the saccula, kinocilia are directed __ the striola.
away from
Which otolith organ senses horizontal movement?
utricle
Which otolith organ senses vertical movement?
saccule
What are the CaCO3 crystals in the otolithic membrane?
otoconia
What does the lateral vestibulospinal tract do?
changes muscle tone in response to gravity
What does the medial vestibulospinal tract do?
gaze
Where does the lateral vestibulospinal tract receive input from?
utricle and saccule
Where does the medial vestibulospinal tract receive input frmo?
semicircular canals
Where does the medial vestibulospinal tract end?
cervical muscles
Where does the lateral vestibulospinal tract end?
postural muscles
What causes Meniere’s disease?
liquid accumulation in inner ear
What are the mini-gyri on the cerebellum called?
folia
What structure makes up the midline of the cerebellum?
vermis
What are the two major fissures of the cerebellum?
primarydorsal posterolateral groove
What is the deep groove on the inferior cerebellum?
vallecular cerebelli
What is the largest lobe of the cerebellum?
posterior
What does the superior cerebellar peduncle contain?
cerebellar efferents to brainstem (especially red nucleus)
Where do contralateral pontine axons enter the cerebellum?
middle cerebellar peduncle
What does the inferior cerebellar peduncle contain?
cerebellar afferents from the spinal cord and lower brain stem
Name the deep cerebellar nuclei from lateral to medial:
dentateemboliform (interposed)globose (interposed)fastigial
Where does the fastigial nucleus receive inputs from?
vermis
Where does the interposed nuclei receive inputs from?
paravermal zone
Where does the dentate nucleus receive inputs from?
cerebellar hemispheres
List the parts of the vestibulocerebellar strip.
cortex of the vermisflocculonodular lobefastigial nucleus