HSC differentiation: cells, growth factors, and cytokines Flashcards
(27 cards)
What are the 2 common progenitor cells that arise from HSCs
Common Myeloid cells
Common Lymphoid cells
Common myeloid progenitors include:
RBCs, granulocytes, and mononuclear cells
a mast cell is an example of what type of cell
granulocyte
a macrophage is an example of what type of cell
mononuclear cell
a basophil is an example of what type of cell
granulocyte
a neutrophil is an example of what type of cell
granulocyte
a myeloid dendritic cell is an example of what type of cell
mononuclear cell
an eosinophil is an example of what type of cell
granulocyte
Common lymphoid progenitors include
NK cells and Lymphocytes (T-cells, B-cells, and Plasma Cells)
What Growth Factors/ Cytokines produce Myeloid Progenitors
IL-3 & GM-CSF
What Growth Factors/ Cytokines produce lymphoid progenitors
IL-7
What Growth Factors/ Cytokines produce basophils
IL-4
What Growth Factors/ Cytokines produce neutrophils
G-CSF
What Growth Factors/ Cytokines produce Eosinophils
IL-5
What Growth Factors/ Cytokines produce Monocytes and Macrophages
GM-CSF and/or M-CSF
What Growth Factors/ Cytokines produce Dentritic cells
Flt3L
What Growth Factors/ Cytokines produce T-cells
IL-2 and IL-7
What Growth Factors/ Cytokines produce B-cells
a lot but mostly IL-3 and IL-7
IL-3 and GM-CSF are important in the differentiation of what type of cells
Myeloid progenitor cells
IL-7 is important in the differentiation of what type of cells
lymphoid progenitor cells
IL-4 is important in the differentiation of what type of cells
Basophils
G-CSF is important in the differentiation of what type of cells
neutrophils
IL-5 is important in the differentiation of what type of cells
eosinophils
GM-CSF and/ or M-CSF are important in the differentiation of what type of cells
monocytes and macrophages
