Hsv Part 2 Flashcards
(24 cards)
What is the primary natural host for Cytomegalovirus (CMV)?
Humans
Animal CMV strains do not infect humans.
What is a unique feature of CMV replication?
Some immediate early proteins are translated from mRNAs brought into the infected cell by the parental virion.
What percentage of adults worldwide have antibodies against CMV?
More than 80%.
Which cells are involved in CMV latency?
Monocytes, kidney cells, cervical cells.
How does CMV evade the immune system?
Attaches to MHC I and produces micro RNAs to limit MHC I production.
What are common clinical findings associated with CMV infection?
- Microcephaly
- Seizures
- Deafness
- Jaundice
- Purpura
- Hepatosplenomegaly
- Mental retardation
- Fever
- Lethargy
- Abnormal lymphocyte
- Sore throat
What laboratory diagnostic methods are used for CMV?
- PCR
- Culture
- Biopsy
- Serology
What treatment is commonly used for CMV retinitis?
Ganciclovir.
What is the role of CytoGam in CMV prevention?
Used to prevent disseminated CMV infections in organ transplant patients.
What are the main antigens associated with Epstein-Barr Virus (EBV)?
- VCA (viral capsid antigen)
- EA (early antigen)
- EBNA (Epstein-Barr nuclear antigen)
- LDMA (lymphocyte determinant membrane antigen)
- VMA (viral membrane antigen)
How is EBV primarily transmitted?
Saliva and blood transfusion.
What is the first site of EBV infection in the body?
Oropharynx.
What are the clinical findings of infectious mononucleosis?
- Fever
- Sore throat
- Lymphadenopathy
- Splenomegaly
- Anorexia
- Lethargy
What complications can arise from EBV infection?
- Nasopharyngeal carcinoma
- Hairy leukoplakia
- Burkitt’s lymphoma
- Post-transplant lymphoproliferative disorder (PTLD)
- Hemophagocytic lymphohistiocytosis (HLH)
What is a notable laboratory finding in infectious mononucleosis?
Absolute lymphocytosis with up to 30% abnormal lymphocytes.
What is the treatment approach for EBV infections?
No antiviral therapy.
What are the types of Human Herpesvirus 6 and 7?
Types A, B, C, D, E, F.
What are the primary transmission routes for Herpesvirus 6 and 7?
Saliva and droplets.
What diseases are associated with Herpesvirus 6 and 7 in immunocompromised patients?
- Pneumonia
- Encephalitis
- Hepatitis
What is the main characteristic of Herpesvirus 8 (Kaposi’s Sarcoma-associated herpesvirus)?
It has a lytic cycle and a latent cycle leading to malignancy.
What cells are primarily affected by Herpesvirus 8?
B lymphocytes and endothelial cells.
What are the manifestations of Kaposi’s Sarcoma?
- Reddish-dark purple lesions
- Flat nodules
- Located on skin, oral cavity, GIT, lungs
What is the lab diagnosis method for Herpesvirus 8?
- Biopsy
- PCR
- Serology
What is the treatment for lesions caused by Herpesvirus 8?
Surgery, radiation therapy, chemotherapy.
