HSV + VZV

Question 1

Kaposi sarcoma is caused by …

Answer 1

HHV8

Question 2

Which herpes viruses set up latent infection in sensory nerve ganglia?

Answer 2

1,2,3

Question 3

HHV 5, 4 and 8 set up latent infection in

Answer 3

B lymphocytes

Question 4

HHV5 and 4 set up latent infection in

Answer 4

Epithelial cells

Question 5

HHV6 and 7 set up latent infection in

Answer 5

T lymphocytes

Question 6

HHV 4 sets up latent infection in

Answer 6

both epithelial cells and B lymphocytes

Question 7

Alphaherpes viruses

Answer 7

HSV and VZV
Rapid growth in cell culture
neuronal latency

Question 8

Betaherpes viruses

Answer 8

CMV, HHV6A and B
slow growth
affinity for CD4 lymphocytes

Question 9

Gammaaherpes Viruses

Answer 9

EBV
only grow in lymphoblastoid cell lines
affinity for B lymphocytes

Question 10

Structure of herpes viruses

Answer 10

Lipid envelope
icosahedral capside
dsDNA

Question 11

Genital herpes is classically associated with

Answer 11

HSV2

Question 12

Rates of seropositivity to HSV is highest in

Answer 12

crowded, disadvantaged, lower SEG

Question 13

What is the primary route of HSV1 transmission

Answer 13

oral secretions from individual actively shedding virus

Question 14

What impact fro congenital deficiencies in humeral immunity have on HSV1 infection?

Answer 14

not a significant risk factor for serious HSV disease

Question 15

Impact of deficient cell-mediated immunity on HSV infection?

Answer 15

Congenital + acquired deficiencies in cell mediated immunity ARE associated with severe HSV disease

Question 16

What is the most common presentation of HSV1

Answer 16

Gingivostomatitis

Question 17

typical location of HSV1 encephalitis

Answer 17

fronts-temporal and parietal regions

Question 18

Pneumonitis and hepatitis are common presentation of HSV1 recurrence in

Answer 18

Neonates

Question 19

How does recurrence of HSV1 manifest in immunocompetent individuals

Answer 19

asymptomatic shedding
herpes labialis
keratoconjunctivitis
rare - encephalitis

Question 20

When is an antiviral most effective for HSV1?

Answer 20

within 72hrs of infection starting

Question 21

How doe the majority of HSV2 infections present?

Answer 21

majority are clinically silent

Question 22

T or F HSV1 infection prevents aquisition of HSV2

Answer 22

F

does not present but does reduce the likelihood of

Question 23

are males or females more easily infected with HSV2

Answer 23

FEMALES

Question 24

what is the main risk factor for infection of HSV2

Answer 24

no of sexual partners

Question 25

are genital lesions of HSV usually uni or bilateral?

Answer 25

Bilateral

Question 26

What babies are most at risk of acquiring congenital HSV infection?

Answer 26

Baby born to mother that was seronegative and develops genital herpes in the 3rd trimester

Question 27

what proportion of patients with a primary HSV2 infection report recurrence?

Answer 27

60%

Question 28

VZV peak

Answer 28

spring

Question 29

Peak age of primary infection of VZV

Answer 29

kids <5yrs

Question 30

where is the site of replication + spread of VZV

Answer 30

replicated in nasopharyngeal lymphoid tissue and spreads to RES

Question 31

What part of the skin is infected by VZV

Answer 31

isthmus of hair follicles | rich in stem cells

Question 32

IP of VZV

Answer 32

7-23 days | shorter in immunocompromised

Question 33

what is characteristic of a VZV rash

Answer 33

centripetal | starts peripherally and moves to trunk

Question 34

When are patients with VZV infectious

Answer 34

from 2 days before rash until the vesicles have crusted and no new vesicles are forming

Question 35

What is the most common complication of VZV

Answer 35

secondary bacterial infection

Question 36

is viral pneumonia after VZV more common in adults or kids

Answer 36

adults esp in smokers, pregnant women also children with leukaemia

Question 37

baby with skin scarring, limb hypoplasia and CNS defects is typically caused by

Answer 37

congenital varicella syndrome - infection occurred early, in the 1st trimester

Question 38

What is the most common complication of Zoster

Answer 38

Post-herpetic neuralgia | - pain lasting >4wks after rash onset

Question 39

What is the effectiveness fo antiviral use for ZAP

Answer 39

reduce the incidence, duration and severity of ZAPain if started within 3 days of rash onset