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HTN Flashcards

1
Q

how is captopril taken

A

1 hour before meals

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2
Q

how is aliskiren taken

A

with or without foods (take the same way every day)

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3
Q

avoid high fat foods with what RAAS inhibitor

A

aliskiren

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4
Q

aliskiren side effects

A

hyperkalemia, angioedema, hypotension

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5
Q

aliskiren decreases levels of

A

furosemide

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6
Q

aliskiren is a ___ substrate

A

3A4

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7
Q

B1 receptors are found in the

A

heart

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8
Q

B2 receptors are found in the

A

lungs

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9
Q

what are our alpha and beta blocking agents

A

labetalol (Trandate), carvedilol(Coreg)

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10
Q

beta blocker/nitric oxide agent

A

nebivolol (Bystolic)

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11
Q

what beta blockers have intrinsic sympathomimetic activity

A

Carteolol, Acebutalol, Pindolol, Penbutolol (CAPP)

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12
Q

what is the effect of beta blockers with intrinsic sympathomimetic activity

A

antagonistic + low level agonist activity at beta receptor

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13
Q

beta blockers with intrinsic sympathomimetic activity are useful in what pt populations

A

those with excessive bradycardia

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14
Q

beta 1 selectivity agents

A

Atenolol, Metoprolol, Esmolol, Bisoprolol, Betaxolol, Acebutolol (AMEBBA) or (A thru M minus C)

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15
Q

what beta blocker is very lipophilic

A

propranolol = more CNS side effects = sedation, depression, cognitive effects

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16
Q

how is carvedilol taken

A

with food (ALL FORMS OF CARVEDILOL)

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17
Q

does carvedilol CR = IR

A

no, CR is less bioavailable than IR

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18
Q

what is used 1st line to treat HTN in pregnancy

A

labetalol

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19
Q

what agents can be used to treat HTN in pregnancy

A

labetolol, nifedipine, methyldopa

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20
Q

what symptoms of hypoglycemia can beta blockers not cover

A

sweating (diaphoresis) & hunger

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21
Q

non selective beta blockers should be avoided in pt with

A

emphysema, COPD, asthma (use low dose beta one selective agent)

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22
Q

drug of choice for pt with aortic dissection

A

beta blockers

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23
Q

contraindications to beta blockers

A

Sinus bradycardia, 2nd or 3rd degree heart block, sinus sick syndrome w/o pacemaker, cardiogenic shock, active asthma exacerbation

24
Q

beta blocker side effects

A

hypotension, decrease HR, dizziness, depression, sexual dysfunction, hyperglycemia (non selective agents), weight gain

25
what are the lipid profile effects of beta blockers
decrease HDL increase TG
26
decrease the dose of the beta blocker if the HR is
< 55
27
what beta blockers must be taken with food
carvedilol all forms, IR lopressor
28
how is toprol XL taken
with or without food
29
bystolic
nebivolol: 5-40mg/QD; start at 2.5mg QD if CrCl <30 or moderate liver impairment. use causation with 2D6 inhibitors
30
what are our non selective beta blockers
Timolol, Propranolol, Pindolol, Penbutolol, Nadolol, Carteolol
31
Corgard
nadolol
32
Levatol
penbutolol
33
Inderal LA
propranolol
34
InnoPran XL
propranolol
35
Coreg
carvedilol
36
Trandate
labetalol
37
Coreg IR 3.125 mg BID equals to what dose of Coreg CR
10 mg daily
38
Coreg CR 80 mg qd equalts to what dose of Coreg IR
25 mg BID
39
Coreg IR 12.5 mg bid equals to what dose of Coreg CR
40 mg daily
40
what is the drug of choice in hypertensive emergency w/ acute myocardial ischemia
IV nitroglycerin
41
which antihypertensive agent acts through depletion of catecholamines in nerve terminals
reserpine
42
labetalol has activity at what receptors
alpha, beta 1 and beta 2 blocker
43
carvedilol has activity at what receptors
alpha, beta 1 and beta 2 blocker
44
Oretic
hctz- tablet
45
which ACE-I has the shortest half life
captopril
46
AGENTS to *AVOID* in PREGNANCY *(hCG+)*
STATINS, RAAS Inhibitor, atenolol
47
bumetanide
0.5-2mg QD or divided, IV fromulation protect from light
48
eplerenone (Inspra) unique contraindication
concomitant use of strong 3A4 inhibitor ( G-PACMAN)
49
diuretics or RAAS inhibitors + lithium interaction
decrease lithium renal clearance = increased risk lithium toxicity
50
loop diuretics increase this toxicity if given with vancomycin or aminoglycosides
ototoxicity
51
captopril (Capoten) specific side effects
tast perversion, rash
52
which calcineurin antagonist increase aliskiren levels
cyclosporin
53
which statin increase aliskiren levels
Atorvastatin
54
Coreg IR 6.25mg BID is equal to what dose Coreg CR
20mg QD
55
Beta blocker effects on diabetes agents
increase effects of insulin & oral hypoglycemic a gens ( sulfonylureas)
56
Carvedilol is a substrate of
2D6 = caution with inhibitors & rifampin will decrease levels
57
Carvedilol cause what to the levels of dig oxen & cyclosporinr
increases them

HTN (5 decks)

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