Hyaline Opportunists Flashcards

(42 cards)

1
Q

Natural habitat for hyaline opportunists

A

Nature

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2
Q

Which type of patient is typically infected w/ hyaline opportunists?

A

Immunocompromised

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3
Q

Mode of transmission for most fungal infections

A
  • Most often inhaled

- Ingestion or direct inoculation is less common

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4
Q

Four conditions (defects in immune system) that commonly predispose individuals to opportunistic fungal infections

A
  • Diabetes
  • Granulocytopenia
  • Absence of cellular immunity
  • AIDS
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5
Q

Most common patient population that acquires mucormycoses

A

Type I diabetics (poorly controlled or in ketoacidosis)

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6
Q

What is the name for aseptate, hyaline fungi?

A

Mucorales (formerly Zygomycetes)

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7
Q

List the four organisms that are agents of mucormycoses

A
  • Rhizopus
  • Mucor
  • Rhizomucor
  • Lichtheimia (formerly Absidia)
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8
Q

Most common agent of mucormycoses and is difficult to treat?

A

Rhizopus

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9
Q

Mucorales

- Most common route of infection

A

Inhalation

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10
Q

Mucorales

- More common clinical presentations observed in patients

A
  • Rhinocerebral → nasal sinus infection that spreads to orbits or the brain
  • Pulmonary and systemic infections (esp. in BM transplant patients)
  • Predilection for invading blood vessels (infarctions)
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11
Q

Mucor

- Microscopic morphology

A

NO RHIZOIDS`

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12
Q

Rhizopus

- Microscopic morphology

A
  • Usually unbranched sporangiophores

- Distinct rhizoids at base of sporangiophore (collapsed umbrellas)

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13
Q

Rhizomucor

- Microscopic morphology

A
  • Usually branched sporangiophores

- Rhizoids

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14
Q

Lichtheimia

- Microscopic morphology

A
  • Usually branched sporangiophores

- Delicate (and often difficult to find) rhizoids appear at points BETWEEN sporangiophores (internodal)

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15
Q

What is the name for septate, hyaline fungi?

A

?

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16
Q

Aspergillus fumigatus

- Colony morphology

A

Blue-gray/blue-greenish colonies

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17
Q

Aspergillus fumigatus

- Microscopic morphology

A
  • Conidia cover only 1/2 of the vesicle

- Uniserate (one row of phialides)

18
Q

Aspergillus flavus

- Colony morphology

A

Yellow/brown colonies

19
Q

Aspergillus flavus

- Microscopic morphology

A
  • Conidia cover most of the vesicle
  • Biserate or uniserate
  • Rough (spiny) conidiophores
20
Q

Aspergillus terreus

- Colony morphology

A

Cinnamon-colored colonies

21
Q

Aspergillus terreus

- Microscopic morphology

A

Biserate phialides covering upper half of vesicle

22
Q

Aspergillus niger

- Colony morphology

A

Black dots on white

23
Q

Aspergillus niger

- Microscopic morphology

A

Biserate phialides covering the entire vesicle

24
Q

Penicillium

- Colony morphology

A

Greenish or yellow-green colonies

25
Penicillium | - Microscopic morphology
- Brush-like appearance of phialides (no vesicle) | - Round conidia in chains
26
Paecilomyces | - Colony morphology
Colonies are often light pastel colors
27
Paecilomyces | - Microscopic morphology
- Long, tapered phialides | - Oval conidia
28
Scopularioposis | - Colony morphology
Buff to brown colonies
29
Scopularioposis | - Microscopic morphology
Conidia represent a long "string of light bulbs"
30
Acremonium | - Colony morphology
Fuzzy
31
Acremonium | - Microscopic morphology
Oval conidia in clusters
32
Sepedonium | - Microscopic morphology
- Macroconidia resembles Histoplasma capsulatum | - Cigar-shaped macroconidia
33
Pseudallescheria boydii/Scedosporium boydii | - Microscopic morphology
Single conidia on ends of conidiophores ("lollipop")
34
Fusarium | - Colony morphology
Lavendar to rose-colored clonies
35
Fusarium | - Microscopic morphology
Sickle-shaped macroconidia
36
Sepedonium macroconidia resembles Histoplasma. How do they differ based on pathogenicity?
- Histoplasma is pathogenic | - Sepedonium is non-pathogenic
37
Aspergillus | - Clinical presentations
- NEUTROPENIA!!!! - Allergic aspergillus - Fungus ball - Disseminated aspergillosis
38
This is an overgrowth in an old TB or Histoplasma cavity; noninvasive; tangled masses of septate hyphae are present
Fungus ball
39
How does Aspergillus become disseminated?
- It produces elastase allowing it to invade and destroy blood vessels - Surrounding tissue undergoes infarction
40
Fusarium | - Clinical presentation
Keratitis
41
Aspergillus spp | - How is it acquire?
Inhalation
42
Fusarium | - How is it acquired?
Found in ReNu contact solution