Hyperhidrosis, Leprosy

Question 1

inhibits pathway involved in neutrophil chemotaxis

Answer 1

dapsone

Question 1

increases toxicity of dapsone

Answer 1

rifampin

Question 2

Where are eccrine sweat glands?

Answer 2

feet forehead palm cheek

Question 2

discolors body fluids

Answer 2

rifampin clofazimine

Question 2

immunosuppresive leprosy trx

Answer 2

clofazimine

Question 3

hepatitis and jaundice (leprosy trx)

Answer 3

clofazimine

Question 4

rifampin MOA

Answer 4

inhibits bacterial DNA-dep-RNA polymerase

Question 4

clofazimine MOA?

Answer 4

binds mycobacterial guanine in DNA (mycobac have more GC than humans)

Question 5

anti-angiogenic and teratogenic (leprosy trx)

Answer 5

thalidomide

Question 7

Dapsone syndrome

Answer 7

hemolysis, methoglobinemia, hepatitis, cholestatic jaundice, periph neuropathy, hypoalbuminemia, psychosis, leukopenia, agranulocystosis

Question 8

Botulinum s/e?

Answer 8

systemic botulism (rare) dry mouth HA fatigue neck pain eye problems

Question 10

Botulinum toxin heavy chain binds:

Answer 10

cell membrane

Question 11

Causes Steven Johnson syndrome

Answer 11

dapsone

Question 12

rash on upper limbs and forehead (leprosy trx)

Answer 12

dapsone

Question 13

severe liver toxicity; CYP inducer (leprosy trx)

Answer 13

rifampin

Question 14

Glycopyrrolate MOA

Answer 14

anticholinergic antimuscarinic

Question 15

folate antagonist

Answer 15

dapsone

Question 16

competes for active site of dihydropteroate synthetase

Answer 16

dapsone

Question 17

Botulinum blocks:

Answer 17

nicotinic R muscarinic R

Question 18

Where are apocrine sweat glands?

Answer 18

axilla urogenital

Question 19

hematuria, hemaglobinuria (leprosy trx)

Answer 19

rifampin

Question 21

Increases serum dapsone

Answer 21

trimethoprin

Question 22

minocycline MOA

Answer 22

inhibits ribosome 30S subunit

Question 23

dose-dependent anti-inflammatory action (leprosy trx)

Answer 23

clofazimine

Question 24

somnolence

Answer 24

thalidomide

Question 25

thalidomide MOA

Answer 25

blocks TNF-alpha production, thus blocking leukocyte migration (via Nfkb mediated transcriptional regulation)

Question 26

decreases toxicity of dapsone

Answer 26

cimetidine and omeprazole

Question 27

Drug that contains albumin

Answer 27

Botulinum toxin

Question 29

Botulinum toxin light chain:

Answer 29

cleaves SNAP25, which enables fusion of ACh vesicles with cell membrane

Question 30

Increases HIV viral load

Answer 30

thalidomide