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Hyperlipidaemia Flashcards

1
Q

What is hyperlipidaemia?

A

high blood levels of cholesterol, triglycerides or both

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2
Q

what can hyperlipidaemia lead to?

A

cardiovascular disease

hyperlipidaemia causes atherosclerosis and in turn:
- coronary heart disease (angina, myocardial infarctions)
- strokes and transient ischaemic attacks (TIA)
- peripheral arterial disease

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3
Q

What is the difference between primary and secondary prevention of cardiovascular event?

A

In summary, primary prevention aims to prevent the initial occurrence of cardiovascular disease, while secondary prevention focuses on preventing recurrent events and managing established heart disease.

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4
Q

Who needs primary prevention of cardiovascular disease?

A
  • type 1 diabetes mellitus
  • type 2 diabetes mellitus only if CVD risk > 10%
  • if risk calculators e.g. QRISK 2: 10 year CVD risk > 10%
  • chronic kidney disease or albuminuria
  • familial hypercholesterolaemia
  • 85 years and above (reduce risk of non- fatal myocardial infarction)
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5
Q

who needs secondary prevention of cardiovascular disease?

A

those with established CVD

coronary heart disease (angina, MI)
cerebrovascular disease (stroke/ transient ischaemic attack)
peripheral arterial disease

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6
Q

who can we NOT use the QRISK2 tool for?

A

patients at high cardiovascular risk as their score will be underestimated

this includes:
- type 1 diabetes mellitus
- established cardiovascular disease
- over 85 years
- chronic kidney disease (eGFR <60mL/min/1.73m2)
- familial hypercholesterolemia

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7
Q

how is hyperlipidaemia diagnosed?

A

6mmol/L total cholestrol

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8
Q

What are TOTAL cholesterol targets for HEALTHY ADULTS?

A

≤ 5mmol/ L

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9
Q

What are TOTAL cholesterol targets for HIGH RISK ADULTS?

A

≤ 4 mmol/L

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10
Q

what are LDL cholesterol targets for HEALTHY ADULTS?

A

≤ 3 mmol/L

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11
Q

What are LDL cholesterol targets for HGIH RISK ADULTS?

A

≤ 2 mmol/L

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12
Q

What should HDL levels be?

A

> 1 mmol/L

(‘good’ cholesterol- higher the better!)

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13
Q

What should Triglycerides levels be?

A

<1.7 mmol/L

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14
Q

What are causes of hyperlipidaemia?

A

DRUGS and CONDITIONS

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15
Q

What drugs can cause hyperlipidaemia?

A
  • antipsychotics
  • immunosuppressants
  • corticosteroids
  • antiretrovirals (HIV drugs)
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16
Q

What conditions can cause hyperlipidaemia?

A
  • hypOthyroidism
  • liver or kidney disease
  • diabetes mellitus
  • family history of high cholesterol
  • lifestyle factors: smoking, excess alcohol consumption, obesity and a poor fatty diet
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17
Q

What are examples of hyperlipidaemia drugs?

A

statins
bile acid sequestrants
fibrates
nicotinic acid group
ezetimibe
lomitapide
alirocumab

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18
Q

What are examples of statins?

A

atorvastatin
fluvastatin
pravastatin
rosuvastatin
simvastatin

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19
Q

What are examples of bile acid sequestrants?

A

colesevelam
colestipol
colestyramine

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20
Q

What are examples of fibrates?

A

bezafibrates
ciprofibrate
fenofibrate
gemfibrozil

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21
Q

What are examples of nicotinic acid group?

A

acipimox
nicotinic acid
omega- 3 fatty acid

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22
Q

what is the mechanism of action of statins?

A

Statins work by inhibiting an enzyme called HMG-CoA reductase. This enzyme is involved in the liver’s production of cholesterol, a key component of lipoproteins (such as LDL, low-density lipoprotein) in the blood.

Lowers LDL cholesterol synthesis by the liver via inhibition of HMG- CoA reductase

By inhibiting HMG-CoA reductase, statins reduce the production of cholesterol within liver cells. This leads to a decrease in the intracellular levels of cholesterol.

Also, As a response to reduced intracellular cholesterol levels, liver cells increase the number of LDL receptors on their surface. These receptors are responsible for capturing LDL cholesterol particles circulating in the blood.

This process helps lower the levels of LDL cholesterol circulating in the blood.

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23
Q

Which statins must be taken at night?

A

All of them except Atorvastatin

(cholesterol synthesis greater at night; more effective)

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24
Q

What are examples of high- intensity statins?

A
  • atorvastatin 20mg- 80mg
  • rosuvastatin 10mg
    -simvastatin 80mg
25
What statin is high intensity statin choice for prevention of cardiovascular prevention?
atorvastatin
26
what is atorvastatin dose for PRIMARY PREVENTION?
20mg OD
27
what is atorvastatin dose for SECONDAY PREVENTION?
80mg OD
28
What is MHRA warning for simvastatin 80mg?
high risk of myopathy give only if high risk of cardiovascular complications or severe hypercholesterolaemia and treatment goals not achieved at lower dose
29
which high- intensity statins are used to prevent cardiovascular disease?
atorvastatin rosuvastatin simvastatin
30
how is hyperlipidaemia treated?
statin first choice
31
how is primary hypercholesterolaemia and familial hypercholesterolaemia treated?
high intensity statin If statin not tolerated or contra- indicated= ezetimibe
32
how is moderate hypertriglyceridemia treated?
high intensity statin if statin not tolerated or contra- indicated = fibrate
33
how is severe hyperlipidaemia treated?
add on ezetimibe (under specialist supervision)
34
if a persons triglycerides are still high after LDL reduced?
add fibrate or nicotinic acid (also lowers LDL)
35
Before starting statins, we MUST address any secondary causes of dyslipidaemia. What may these be?
- hypothyroidism - uncontrolled diabetes mellitus - nephrotic syndrome (albuminuria) - liver disease e.g. alcoholic cirrhosis
36
What are side effects of statins?
myopathy myositis rhabdomyolysis patient counselling: report tender, weak and painful muscles
37
Who has a higher risk of muscle toxicity?
- personal or family history of muscle disorder - high alcohol intake - renal impairment - hypothyroidism (treat before starting statin)
38
When is there an increased risk of myopathy?
- concomitant ezetimibe or fibrates, especially gemfibrozil - concomitant fusidic acid: restart statin 7 days after last dose (increased risk of rhabdomyolysis)
39
How should we counsel patients who have interstitial lung disease and are taking statins?
report short breath, cough, weight loss
40
why should we take caution when giving statins to diabetics or those at high risk of diabetes?
statins can raise HbA1c or blood glucose levels
41
How can we monitor those on statins?
baseline lipid profile renal function thyroid function HbA1c if high risk of developing diabetes
42
When should we discontinue statins for a patient?
If - severe muscle symptoms - if creatinine kinase levels are 5 x normal* - if liver transaminases 3x normal (liver function) *if level returns to normal and muscle symptoms resolve a statin can be reintroduced at a lower dose and monitor)
43
What drugs interact with statins?
drugs that increase statin levels as = increased myopathy risk macrolide antibiotic e.g. clarithromycin (patient counselling: stop taking statin until antibiotic course completed. There is no need to contact the prescriber) ezetimibe/ fibrates especially gemfibrozil : AVOID! fusidic acid (restart statin 7 days after last ORAL fusidic acid dose)
44
What are statin dose adjustment's due to interactions for: SIMVASTATIN
Max. 10mg with fibrate Max. 20mg with amiodarone, amlodipine, diltiazem, verapamil
45
What are statin dose adjustment's due to interactions for: ATORVASTATIN
Max. 10mg with ciclosporin
46
What are statin dose adjustment's due to interactions for: ROSUVASTATIN
Initially 5mg Max. 20mg with clopidogrel
47
Can you take statins whilst being pregnant?
NO as TERATOGENIC Effective contraception must be used DURING AND 1 month after stopping Stop taking the statin 3 months before conceiving and restart after breastfeeding finished
48
What is the mechanism of action of ezitimibe?
TO DO WITH CHOLESTROL ABSORPTION! Cholesterol absorption occurs through specialized transporters in the intestinal cells, including the NPC1L1 (Niemann-Pick C1-Like 1) protein. Ezetimibe acts as a cholesterol absorption inhibitor by selectively blocking the NPC1L1 protein in the small intestine. This protein plays a key role in cholesterol uptake from the digestive tract. Ezetimibe inhibits NPC1L1, reducing the absorption of cholesterol from the diet. As a result, less dietary cholesterol enters the bloodstream. leads to a decrease in the concentration of LDL cholesterol in the bloodstream over time, as the liver compensates by removing LDL cholesterol from circulation.
49
What is an alternative to statin in familial and primary hypercholesterolaemia?
ezitimibe
50
what are interactions of ezitimibe?
statins as can cause myopathy= rhabdomyolysis
51
what is the mechanism of action of fibrates
fibrates lower blood triglyceride levels by reducing the livers production of VLDL (the triglyceride- carrying particle that circulates in the blood) and by speeding up the removal of triglycerides from the blood
52
how can we treat those with severe hypertriglyceridaemia > 10mmol/L or in those who cannot tolerate a statin (specialist)
- bezafibrate - fenofibrate - ciprofibrate - gemfibrozil (do not use with statin as high risk of myopathy - rhabdomyolysis)
53
What are interactions of fibrates?
statins (myopathy, renal impairment)
54
What is the mechanism of action of bile acid sequestrants?
they bind and sequesters bile acids the liver then produces more bile acids to replace those that have been lost The body uses cholestrol to make bile acids This reduces the amount of LDL cholestrol ciruclating in the blood
55
what are examples of bile acid sequestrants?
colesevelam colestipol colesytramine
56
what are interactions of bile acid sequestrants?
impair absorption of fat- souble vitamins ADEK and other drugs pt counselling: take other drugs 1 hour BEFORE (4 hours for colevesalm) OR 4 hours AFTER bile acid sequestrant
57
when are omega- 3 fatty acids used in hyperlipidaemia?
no evidence for use used an adjunct to statins and diet to lower triglycerides
58
when are nicotinic acid groups used in hyperlipidaemia?
specialist use use limited by flushing (prostaglandin- mediated)
59

Cardiovascular Nafisa (9 decks)

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