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Therapeutics > Hyperlipidemia > Flashcards

Hyperlipidemia Flashcards

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1
Q

Lescol Generic

A

Fluvastatin

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2
Q

Livalo Generic

A

Pitavastatin

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3
Q

Mevacor/Altoprev Generic

A

Lovastatin

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4
Q

Pravachol Generic

A

Pravastatin

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5
Q

Zocor Generic

A

Simvastatin

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6
Q

Lipitor Generic

A

Atorvastatin

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7
Q

Crestor Generic

A

Rosuvastatin

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8
Q

Fluvastatin Dose

A

Low: 20-40 mg/day
Moderate: 80 mg/day

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9
Q

Pitavastatin Dose

A

Low: 1 mg/day
Moderate: 2-4 mg/day

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10
Q

Lovastatin Dose

A

Low: 20 mg/day
Moderate: 40 mg/day

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11
Q

Pravastatin Dose

A

Low: 10-20 mg/day
Moderate: 40-80mg/day

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12
Q

Simvastatin Dose

A

Low: 10 mg/day
Moderate: 20-40mg/day

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13
Q

Atorvastatin Dose

A

Moderate: 10-20mg/day
High: 40-80 mg/day

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14
Q

Rosuvastatin Dose

A

Moderate: 5-10mg/day
High: 20-40 mg/day

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15
Q

Statin Side Effects

A 
Myopathy
Rhabdomyolysis
Muscle pain
Liver enzyme abnormalities
HA
Dyspepsia
Abdominal pain
Nausea
Upper respiratory infection
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16
Q

Statin Monitoring

A

FLP: Baseline, 4-12 wks after starting, then 3-12 months
CK: Baseline, if muscle symptoms
LFT: Baseline, if suspected liver damage
Muscle pain symptoms

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17
Q

Zetia Generic

A

Ezetimibe

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18
Q

Ezetimibe Dose

A

10 mg daily

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19
Q

Ezetimibe Side Effects

A

Arthralgia
Upper respiratory tract infection
Diarrhea

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20
Q

Ezetimibe Monitoring

A

FLP baseline

LFTs

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21
Q

Praluent Generic

A

Alirocumab

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22
Q

Alirocumab Dose

A

75 mcg SQ q 2 weeks

150 mcg q 2 weeks post 4-8 weeks

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23
Q

Alirocumab Side Effects

A 
GI side effects
↑ LFT
Injection site reaction
Myalgia
Influenza
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24
Q

Alirocumab Monitoring

A

LDL-C within 4-8 weeks of starting or changing dose

Hypersensitivity

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25
Repatha Generic
Evolocumab
26
Evolocumab Dose
120 mcg q 2 weeks | 420 mcg monthly
27
Evolocumab Side Effects
``` GI side effects ↑ LFT Injection site reaction Myalgia Influenza ```
28
Evolocumab Monitoring
LDL-C within 4-8 weeks of starting or changing dose | Hypersensitivity
29
Lovaza Generic
Omega-3-acid ethyl esters
30
Omega-3-acid ethyl esters Dose
4 g daily | 2 g BID
31
Omega-3-acid ethyl esters Side Effects
``` GI – diarrhea Dysgeusia Dyspepsia Eructation Nausea ```
32
Omega-3-acid ethyl esters Monitoring
TG and LDL at baseline and periodically ALT periodically GI disturbances, skin changes, bleeding
33
WelChol Generic
Colesevelam
34
Colesevelam Dose
3. 75 g once daily | 1. 875 g BID
35
Colesevelam Side Effects
``` ↑ TG Constipation Bloating Nausea Flatulence ↓ absorption of fat-soluble vitamins Hypernatremia Hyperchloremia GI Obstruction ```
36
Colesevelam Monitoring
FLP: Baseline, 3 months after, q 6—12 months after | Should not use if TG>300 mg/dL
37
Questran/Prevalite Generic
Cholestyramine
38
Cholestyramine Dose
4g (1 packet or scoop) once or 2 times daily | Max: 24 g/day
39
Cholestyramine Side Effects
``` ↑ TG Constipation Bloating Nausea Flatulence ↓ absorption of fat-soluble vitamins Hypernatremia Hyperchloremia GI Obstruction ```
40
Cholestyramine Monitoring
FLP: Baseline, 3 months after, q 6—12 months after | Should not use if TG>300 mg/dL
41
Colestid Generic
Colestipol
42
Colestipol Dose
Start: 5g once or twice a day Increase by 5g at 1-2 month intervals Go up to 30g/day or in divided doses
43
Colestipol Side Effects
``` ↑ TG Constipation Bloating Nausea Flatulence ↓ absorption of fat-soluble vitamins Hypernatremia Hyperchloremia GI Obstruction ```
44
Colestipol Monitoring
FLP: Baseline, 3 months after, q 6—12 months after | Should not use if TG>300 mg/dL
45
Niacor/Niaspan/Slo-Niacin Generic
Niacin
46
Niacin Dose
Start: 500 mg at bedtime for 4 weeks Go to 1 g at bedtime for 4 weeks Max: 2g/day Usual: 1-2 g/day at bedtime
47
Niacin Side Effects
Prostaglandin mediated flushing and itching Skin rash Upset stomach Low blood pressure when standing
48
Niacin Monitoring
LFT baseline FBH or A1C Uric acid Monitor during titration and every 6 months after
49
Lopid Generic
Gemfibrozil
50
Gemfibrozil Dose
600 mg BID 30 mins AC Adjust following lipid determinations at 4-8 week intervals Consider reducing if lipids significantly lower than target
51
Gemfibrozil Side Effects
``` GI disturbances Rash Myalgia Dizziness Anemia, leukopenia, thrombocytopenia Renal insufficiency ```
52
Gemfibrozil Monitoring
Serum cholesterol LFTs CBC – first year
53
Tricor Generic
Fenofibrate
54
Fenofibrate Dose
48-145 mg/day Max: 145 mg/day Adjust following lipid determinations at 4-8 week intervals Consider reducing if lipids significantly lower than target
55
Fenofibrate Side Effects
``` GI disturbances Rash Myalgia Dizziness Anemia, leukopenia, thrombocytopenia Renal insufficiency ```
56
Fenofibrate Monitoring
Periodic blood cell count: first year FLP every 6-8 weeks until goal then every 4-6 months LFTs Renal function: Baseline, 3 months after, every 6 months
57
Trilipix/Fibricor Generic
Fenofibric Acid
58
Fenofibric Acid Dose
Trilipix: 45-135mg/day Max: 135mg/day Fibricor: 35-105 mg/day Max: 105 mg/day Adjust following lipid determinations at 4-8 week intervals Consider reducing if lipids significantly lower than target
59
Fenofibric Acid Side Effects
``` GI disturbances Rash Myalgia Dizziness Anemia, leukopenia, thrombocytopenia Renal insufficiency ```
60
Fenofibric Acid Monitoring
Periodic blood cell count: first year FLP every 6-8 weeks until goal then every 4-6 months LFTs Renal function: Baseline, 3 months after, every 6 months
61
Vytorin Generic
Simvastatin and Ezetimibe
62
Juvisync Generic
Simvastatin with Sitagliptin

Therapeutics (7 decks)

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