Hypersensitivity & Autoimmunity

Question 1

what are the antigens of MS?

Answer 1

myelin basic protein and proteolipid protein

Question 2

what HS rxn is MS?

Answer 2

type IV

Question 3

what is the antigen for grave’s disease?

Answer 3

thyroid stimulating hormone receptor

Question 4

what HS rxn is graves?

Answer 4

type II

Question 5

what is the antigen and consequence of subacute bacterial endocarditis?

Answer 5

• bacterial antigen

- glomerulonephritis

Question 6

what HS rxn is subacute bacterial endocarditis (or anything else that causes glomerulonephritis?)

Answer 6

type III

Question 7

how can you distinguish between goodpasture’s disease and regular glomerulonephritis?

Answer 7

“lumpy-bumpy” immunological test. regular glomerulonephritis is “lumpy-bumpy” but goodpasture’s is smooth

Question 8

what is the antigen for mixed essential cryoglobulinemia?

Answer 8

rheumatoid factor IgG complexes

Question 9

what type HS rxn and outcome of mixed essential cryoglobulinemia?

Answer 9

type III; systemic vasculitis

Question 10

what’s the antigen for rheumatoid arthritis?

Answer 10

unknown synovial joint antigen

Question 11

what type of HS rxn is rheumatoid arthritis?

Answer 11

type IV

Question 12

what’s the antigen for myasthenia gravis?

Answer 12

acetylcholine receptor

Question 13

what type of HS rxn is myasthenia gravis?

Answer 13

type II

Question 14

what’s the antigen for pemphigus vulgaris and what’s the consequence?

Answer 14

epidermal cadherin; blistering of skin

Question 15

what’s the HS rxn for pemphigus vulgaris?

Answer 15

type II

Question 16

what are the antigens for systemic lupus erythromatosus and what are the consequences?

Answer 16

• DNA, histones, ribosomes, snRNP, scRNP

- glomerulonephritis, vasculitis, arthritis

Question 17

what HS rxn is systemic lupus erythromatosus?

Answer 17

type III

Question 18

what is the antigen of goodpastures syndrome?

Answer 18

non-collagenous domain of basement membrane of collagen type IV (lungs and kidneys)

Question 19

what are the consequences of goodpastures?

Answer 19

glomerulonephritis and pulmonary hemorrhage!

Question 20

what type of HS rxn is goodpastures?

Answer 20

type II

Question 21

what is the antigen and consequence for type 1 diabetes?

Answer 21

pancreatic beta cell antigen; beta cell destruction

Question 22

what type of HS rxn is type 1 diabetes?

Answer 22

type IV

Question 23

what is the antigen for autoimmune hemolytic anemia and what is the consequence?

Answer 23

Rh blood group antigens; destruction of red blood cells

Question 24

what type of HS rxn is autoimmune hemolytic anemia?

Answer 24

type II

Question 25

what is the neonatal version of autoimmune hemolytic anemia?

Answer 25

erythroblastosis fetalis

Question 26

what is the antigen and consequence for immune thrombocytopenia purpura?

Answer 26

platelet integrin gpIIb:gpIIIa; abnormal bleeding

Question 27

what type of HS rxn is ITP?

Answer 27

type II

Question 28

what is the antigen and consequence for acute rheumatic fever

Answer 28

- streptococcal cell wall antigens | - arthritis, myocarditis, scarring of heart valves

Question 29

what type of HS rxn is acute rheumatic fever?

Answer 29

type II

Question 30

what is the antigen and consequence of type 2 diabetes?

Answer 30

insulin receptor (antagonist); hyperglycemia

Question 31

what is the antigen for hypoglycemia?

Answer 31

insulin receptor (agonist)

Question 32

what type of HS rxn are type 2 diabetes and hypoglycemia?

Answer 32

type II

Question 33

what's a good example of a type I HS rxn?

Answer 33

food allergies; peanuts

Question 34

what type of HS rxn is urticaria (hives)?

Answer 34

type II

Question 35

what type of HS rxn is serum sickness?

Answer 35

type III

Question 36

what type of HS rxn is poison ivy?

Answer 36

type IV

Question 37

list the three transplant rejections and what HS rxns they are

Answer 37

- hyperacute (type II) - chronic (type III) - acute (type IV)

Question 38

what type of HS rxn is sympathetic ophthalmia?

Answer 38

type IV ( i think ) Th1 cell mediated

Question 39

mutations in AIRE gene causes?

Answer 39

- wide range of autoimmunity | - defective thymic deletion of autoreactive T cells

Question 40

what is IPEX?

Answer 40

mutations in FOXP3+ on Treg cells

Question 41

what disease is associated with the DQ2/DQ8 haplotypes?

Answer 41

- celiac disease - type 1 diabetes - coxsackie virus A/B

Question 42

b27 haplotype?

Answer 42

- ankylosing spondylitis - chlamydia trachomatis - campylobacter jejuni

Question 43

HLA-DR2/DR4?

Answer 43

borrelia burgdoferi ----> chronic arthritis in lyme disease

Question 44

HLA for group A strep?

Answer 44

unknown; causes rheumatic fever

Question 45

what is an autoimmune consequence of chlamydia?

Answer 45

reiter's syndrome (arthritis)

Question 46

what is the autoimmune consequence of coxsackie viruses?

Answer 46

type 1 diabetes

Question 47

what is the autoimmune consequences of c. jejuni?

Answer 47

GBS and arthritis

Question 48

the antigen MAGE-1 is found in what kind of cancer?

Answer 48

melanoma

Question 49

what's a tissue specific antigen found on normal and cancerous cell that produce melanin?

Answer 49

tyrosinase

Question 50

what is CEA antigen?

Answer 50

oncofetal antigen for colon cancer (carcinoembryonic antigen)

Question 51

what kind of cancer is alpha-fetoprotein found in?

Answer 51

liver and testes cancer

Question 52

what is CALLA antigen or CD10?

Answer 52

common acute lymphoblastic leukemia antigen

Question 53

what is PSA antigen?

Answer 53

prostate specific antigen