Hypersensitivity Pneumonitis Flashcards Preview

IM Harrison's Pulmo > Hypersensitivity Pneumonitis > Flashcards

Flashcards in Hypersensitivity Pneumonitis Deck (18)
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1
Q

What is the alternative name of Hypersensitivity Pneumonitis

A

Extrinsic allergic alveolitis

2
Q

What is the inflammatory pattern of Hypersensitivity pneumonitis?TH1 or TH2?

A

TH1

3
Q

What Hypersensitivity Pneumonitis may be seen in sugarcane plantation workers?

A

Bagassosis

4
Q

What antigen is involved in cheese washer’s lung?

A

Penicillium casei; Aspergillus clavatus

5
Q

What antigen is common to all of the following: Malt worker’s lung, Tobacco grower’s lung, and Potato riddler’s lung?

A

Aspergillus species

6
Q

HRCT findings in subacute HP

A

Ground glass airspace opacities are characteristic as is the presence of centrilobular nodules

7
Q

HRCT findings of chronic HP

A

Reticular changes and traction bronchiectasis

8
Q

Bronchoalveolar lavage finding in HP

A

BAL lymphocytosis is characteristic of HP

9
Q

Lung biopsy findings in HP

A

Presence of noncaseating granulomas in the vicinity of small airways. Granulomas are loose and poorly defined in nature as compared to sarcoidosis. Within the aveolar spaces and interstitium- mixed cellular infiltrate with a lymphocytic predominance.

10
Q

Mainstay of treatment of HP

A

Antigen avoidance

11
Q

Glucocorticoid therapy in subacute to chronic HP

A

Prednisone therapy 0.5 to 1 mg/kg of body weight not to exceed 60 mg/day or alternative glucocorticoid equivalent x 1-2 weeks followed by a taper of 2-6 weeks

12
Q

Syndrome characterized by fevers, acute respiratory failure that often requires mechanical ventilation, diffuse pulmonary infiltrates and pulmonary eosinophilia in a previously healthy individual.

A

Acute Eosinophilic Pneumonia

13
Q

Diagnostic Criteria of Acute Eosinophilic Pneumonia

A

Acute febrile illness with respiratory manifestations of <1 month in duration
Hypoxemic respiratory failure
Diffuse pulmonary infiltrates on chest x ray
BAL> 25% eosinophilia
Absence of parasitic, fungal, or other infection
Absence of drugs to cause pulmonary eosinophilia
Quick clinical response to corticosteroids
Failure to relapse after discontinuation of corticosteroids

14
Q

Patients present with subacute illness over weeks to months with cough, low-grade fevers, progressive dyspnea, weight loss, wheezing, malaise, night sweats. CXR: migratory bilateral peripheral or pleural-based opacities

A

Chronic Eosinophilic Pneumonia

15
Q

Primary features include asthma, peripheral eosinophilia, neuropathy, pulmonary infiltrates, paranasal sinus abnormality, presence of eosnophilic vasculitis

A

Eosinophilic Granulomatosis with Polyangiitis (EGPA)

16
Q

Which nerve is the most commonly involved in mononeuritis multiplex in EGPA?

A

Peroneal

17
Q

Primary target organ of EGPA?

A

Heart. Patients may have acute pericarditis, constrictive pericarditis, myocardial infarction, other ECG changes.

18
Q

This refers to transient pulmonary infiltrates with eosinophilia that occurs in response to passage of helminthic larvae through the lungs most commonly Ascaris.

A

Loffler Syndrome