Hypertension Flashcards

(48 cards)

1
Q

what is hypertension?

A

a disorder in which the level of sustained arterial pressure is higher than expected for the age, sex and race of the individual

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2
Q

what is the exact blood pressure considered to be hypertension?

A

> 140/90

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3
Q

what are the two types of hypertension?

A

white coat

stable or labile

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4
Q

what does hypertension eventually cause?

A

cardiac failure

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5
Q

what is hypertension a risk factor for?

A

cerebral haemorrhage
atheroma
renal failure
sudden cardiac death

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6
Q

describe the incidence of hypertension

A
varies between countries
higher in black populations 
lower in south pacific 
familial tendency 
rises with age
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7
Q

what is the classification of hypertension according to cause?

A

primary or secondary

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8
Q

what is the classification of hypertension according to consequences?

A

benign or malignant

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9
Q

how can BP be calculated?

A

CO X PR

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10
Q

what has an effect on CO?

A

HR
contractility
blood volume

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11
Q

what has an effect on PR?

A

constrictors and dilators

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12
Q

describe resistance arteries

A

peripheral resistance

target organ damage

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13
Q

what is primary hypertension?

A

most common

no obvious cause

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14
Q

what can be involved in causing primary hypertension?

A

genetic factors
salt intake
protein intake

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15
Q

which body systems does primary hypertension involve?

A

RAAS

sympathetic activity

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16
Q

what is salt sensitive hypertension?

A

increase in dietary salt leads to increase in BP
some causes primary hypertension
controlled by reduced salt diet

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17
Q

what causes salt sensitive hypertension?

A

genetic polymorphisms

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18
Q

what is secondary hypertension?

A

when underlying disease is implicated eg renal disease, endocrine disease, aortic disease, renal artery stenosis, drug therapy

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19
Q

what are renal causes of hypertension?

A

any renal disease
reduced renal blood flow
excess renin release
salt and water overload

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20
Q

name some renal diseases which may cause hypertension

A

renal artery stenosis, acute or chronic glomerulonephritis, chronic pyelonephritis, cystic diseases, interstitial nephritis

21
Q

what are endocrine causes?

A

adrenal gland hyperfunction/tumours
eg conn’s syndrome- excess aldosterone, cushing’s syndrom- excess corticosteroid, phaeochromocytoma- excess noradrenaline

22
Q

what are other causes?

A

coarctation of the aorta- congenital narrowing of segments of the aorta
drugs- including corticosteroids

23
Q

what is benign hypertension?

A

a cause of serious life threatening morbidity

asymptomatic, incidental finding often health checks

24
Q

what does benign hypertension eventually cause?

A
left ventricular hypertrophy 
congestive cardiac failure 
increases atheroma 
increases aneurysm rupture- aortic dissection, Berry aneurysms 
renal disease
25
what happens during left ventricular hypertrophy?
``` increased LV load poor perfusion interstitial fibrosis micro-infarcts diastolic dysfunction ```
26
what can LV hypertrophy cause?
sudden cardiac death- arrhythmia and poor perfusion cardiac failure affects outcome of other disease
27
what is a subrachnoid haemorrhage?
rupture of berry aneurysm
28
what are the figures of benign hypertension?
Every 10mmHg of diastolic pressure above 85 doubles risk of MI Every 8mmHg of diastolic pressure above 85 doubles risk of stroke
29
what is microvascular injury?
blood vessel wall changes- small arteries and arterioles thickening of media (smooth muscle) hyaline arteriosclerosis
30
where can microvascular injury occur?
retina and kidneys
31
what is hyaline arteriosclerosis?
plasma proteins forced into vessel wall
32
what is malignant hypertension?
serious life threatening condition diastolic presssure > 130-140 needs urgent treatment to prevent death
33
how does malignant hypertension arise?
from either primary or secondary hypertension or arise de-novo
34
what does malignant hypertension cause?
``` cerebral oedema- papilloedema acute renal failure acute heart failure headache and cerebral haemorrhage blood vessels show fibrinoid necrosis and endarteritis proliferans of their walls ```
35
what is pregnancy associated hypertension?
pre-eclampsia- hypertension and proteinuria | hypertension secondary to silent renal or systemic disease
36
what is stage 1 hypertension?
clinic BP is 140/90 mmHg or higher and ABPM or HBPM daytime average is 135/85 mmHg or higher
37
what is stage 2 hypertension?
clinic BP 160/100 mmHg or higher and ABPM or HBPM daytime average is 150/95 mmHg or higher
38
what is severe hypertension?
clinic BP is 180 mmHg or higher or clinic diastolic BP is 110 mmHg or higher
39
what is the main driver for absolute risk of hypertension?
age
40
what is the end organ damage of hypertension?
LV hypertrophy creatinine raised albuminuria/ microalbuminurira retinopathy
41
what drugs are used to treat hypertension?
ACE inhibitors Beta blockers Calcium channel blockers Diuretics (usually thiazide)
42
what is the benefit of combination therapy?
fewer side effects
43
what are the characteristics of resistant hypertension?
``` non-concordance 'white coat' effect pseudo-hypertension lifestyle factors drug interactions secondary hypertension true resistance ```
44
which drug is the most effective in treating resistant hypertension?
spironolactone
45
describe the use of spironolactone
start low; go slow | caution: diabetes and low GFR
46
describe the treatment of hypertension in under 55s
ACE/ARB or B-blocker if fertile female, calcium antagonist, diuretic, spironolactone
47
describe the treatment of hypertension in over 55s
calcium antagonist, ACE/ARB, diuretic, spironolactone
48
what new technologies can be used to treat hypertension?
renal denervation baro-receptor stimulation rox coupler