Hypothalamic and anterior pituitary hormones. Flashcards Preview

Endocrine System (Pre-Reg) > Hypothalamic and anterior pituitary hormones. > Flashcards

Flashcards in Hypothalamic and anterior pituitary hormones. Deck (8)
Loading flashcards...
1
Q

Tetracosactide is an analogue of what?

What is it used to test?

A

Tetracocsactide is an analogue of corticotropin (ACTH) and it is used to test adrenocortical function; failure of the plasma cortisol concentration to rise after administration of tetracosactide indicates adrenocortical insufficiency.

2
Q

FSH and LH together, FSH alone (as in follitropin), or chorionic gonadotrophin, are used in the treatment of what? [2]

A

Infertility in women with proven hypopituitarism or who have not responded to clomifene citrate OR in superovulation treatment for assisted conception.

3
Q

What is clomifene citrate?

A

It is an anti-oestrogen which induces gonadotrophin release by occupying oestrogen receptors in the hypothalamus, thereby interfering with feedback mechanisms, chorionic gonadotrophin is sometimes used as an adjunct

4
Q

What is growth hormone used to treat?

A
  1. GH deficiency in children and in adults.
  2. Prader-Willi syndrome
  3. Turner syndrome
  4. Chronic renal insufficiency
  5. Short children considered small for gestational age at birth, and short stature homeobox-containing gene (SHOX) deficiency.
5
Q

How can short stature homeobox-containing gene (SHOX) deficiency be treated?

A

Growth Hormone.

6
Q

Growth hormone of human origin (HGH; somatotrophin) has been replaced by what?

A

Growth hormone of human sequence, somatropin, produced using recombinant DNA technology.

7
Q

What is licensed to treat growth failure in children and adolescents with severe primary insulin-like growth factor-I deficiency?

A

Mecasermin, a human insulin-like growth factor-I (rhIGF-I).

8
Q

Gonadorelin analogues are indicated in what disease states and conditions?

A

Endometriosis
Infertility
Breast and Prostate Cancer