I-131 Tositumomab (Bexxar)

Question 1

what is it

Answer 1

antibody therapy forNHL

Question 2

administaered in how many parts

Answer 2

2

Question 3

first dose

Answer 3

5 mCi planning dose to establish clearnece rate ad distributoin to determine final therpay dose

Question 4

second dose is therapeutic and typically between

Answer 4

50-100mCi

Question 5

directed against what antigen and where is it found

Answer 5

CD20 antigens on normal and malignant b lymphocytes

Question 6

dx dose

Answer 6

5 mCi

Question 7

Ab prelabeled with

Answer 7

I-131

Question 8

what determines activity of therpaeutic dose

Answer 8

platelet level of pt at time of admin and risdence time of dx dose

Question 9

platelet count over 150,000 dose should be

Answer 9

75cGy whole body total irridatin

Question 10

platelet of 100,000-150,000 dose

Answer 10

65cGy

Question 11

below 100,000 should not be treated

Answer 11

true

Question 12

Bexxar preceded by

Answer 12

infusion of 450 mg of cold antibody

Question 13

total Ab amount of the radioactive dose is a 35 mg radiolabeled and

Answer 13

cold Ab

Question 14

admin through what size filter

Answer 14

0.22 micron

Question 15

what volume for admin

Answer 15

30 mL over 20 min

Question 16

what do you follow inj with

Answer 16

rinsing volume of 30 mL over 10 min